Results 91 to 100 of about 270,351 (261)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Los memes como creaciones de imaginarios instituyentes [PDF]
, 2017 Es un trabajo terminal de grado desarrollado con rigor teórico y metodológico, claramente ubicado en los problemas de la visualidad contemporánea, y con un trabajo de campo interesante, que explora la pertinencia de trabajar con las actitudes en el ...
ARANDA SANCHEZ, JOSE MARIA +1 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Revista Brasileira de Terapia Intensiva, 2010 OBJETIVOS: Lesão renal aguda caracteriza-se pela redução súbita e, em geral, reversível da função renal com perda da capacidade de manutenção da homeostase do organismo.
Kenia Machado Souza Freire +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Revista Brasileira de Terapia Intensiva, 2015 RESUMOObjetivo:Avaliar a incidência de infecções do trato urinário por Trichosporon spp. em uma unidade de terapia intensiva.Métodos:Estudo descritivo observacional realizado em uma unidade de terapia intensiva no período de 2007 a 2009. Foram analisados
Maria das Graças Silva Mattede +5 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
VI Jornada de Cuidados Paliativos do INCA
Revista Brasileira de Cancerologia, 2016 Resumos escolhidos para publicação. Nessa edição, os títulos foram: Fatores Associados à Sobrevida de Pacientes com Câncer Avançado em Cuidados Paliativos; Relação do Estado Nutricional e da Resposta Inflamatória Sistêmica com a Sobrevida de Pacientes ...
Instituto Nacional de Câncer José Alencar Gomes da Silva
doaj +1 more source
New freshwater sponges from Amazonian waters
, 1983 Four species of freshwater sponges have their first register of occurrence for Amazonian waters upon specimens collected from Culuene and Sete de Setembro Rivers (Xingú basin), Tapirapés River (Araguaia basin) and Cuieiras River.
Becker Maciel, S., Volkmer-Ribeiro, C.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source