Results 91 to 100 of about 16,606 (215)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
, 2015 Qualitative descriptive study aimed at describing and analyzing the everyday in managing the financial status of family carers of a member with terminal cancer. The research took the city of Pacasmayo (Peru).
Castañeda Nomberto, Vilma Elizabeth +1 more
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Cuidado humanizado de enfermería al paciente con enfermedad oncológica en estado terminal
, 2020 21 páginasEl cáncer es considerado una de las principales causas de morbilidad y mortalidad en el mundo, cuyo diagnóstico supone para las personas una situación difícil de afrontar, no sólo por los cambios físicos que desarrollan, sino también por las ...
Ulloa Marquin, Jessica
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Análisis del artículo 112 del Código Penal peruano y su incidencia en los derechos fundamentales de pacientes en estado terminal [PDF]
La presente investigación aborda la legalización de la eutanasia y su impacto en los derechos de los pacientes terminales, tanto a nivel internacional como en el contexto peruano, explicando cómo la disposición normativa del artículo 112 del Código ...
Cornelio Montero, Andrea
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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
, 2015 Qualitative descriptive study aimed at describing and analyzing the everyday in managing the financial status of family carers of a member with terminal cancer. The research took the city of Pacasmayo (Peru).
Castañeda Nomberto, Vilma Elizabeth +1 more
core