Results 31 to 40 of about 1,230,897 (338)

Molecular Docking of Citronellol, Geraniol and Ester Derivatives as Pim 1 Kinase Inhibitor of Leukemia Cancer

Jurnal Kimia Valensi, 2019
The proviral insertion site in Moloney murine leukemia virus-1 (Pim1) kinase is overexpressed in many human cancer diseases. Inhibition of Pim1 kinase has been reported can suppress cell proliferation and induce apoptotic cell death, so that the protein ...
Galuh Widiyarti, Firdayani Firdayani, Muhammad Hanafi, Soleh Kosela, Emil Budianto   +4 more
doaj   +1 more source

Stigmasterol-Based Novel Low Molecular Weight/Mass Organic Gelators

Molecules, 2011
Conjugates consisting of stigmasterol and L-phenylalanine, interconnected through short-chained dicarboxylic acyls by ester and amide bonds, respectively, were synthesized as potential low molecular weight/mass organic gelators (LMWGs/LMMGs).
Zdeněk Wimmer, David Šaman, Pavel Drašar, Jana Šusteková   +3 more
doaj   +1 more source

Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents

Molecules, 2019
To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors.
Ming-Jie Chu, Wei Wang, Zi-Li Ren, Hao Liu, Xiang Cheng, Kai Mo, Li Wang, Feng Tang, Xian-Hai Lv   +8 more
doaj   +1 more source

Development and validation of a French job-exposure matrix for healthcare workers: JEM Soignances

Scandinavian Journal of Work, Environment & Health
OBJECTIVES: This study aimed to develop and evaluate a job-exposure matrix (JEM) specific to healthcare workers, JEM Soignances, based on self-reported data. METHODS: The JEM was constructed using data from healthcare workers within the CONSTANCES cohort
Allison Singier, Marc Fadel, Fabien Gilbert, Soignances group, Ester-MESuRS collaboration on occupational risks, Laura Temime, Marie Zins, Alexis Descatha   +7 more
doaj   +1 more source

Chemical Modification of Pectin and Polygalacturonic Acid: A Critical Review

BioResources, 2021
Pectin, as a sustainable biopolymer with its two complementary functionalities (carboxyl and hydroxyl moieties) imparted in the α-1,4-galacturonic acid repeating unit, has gained increasing attention in the last few years.
Hendryk Würfel, Katja Geitel, Haisong Qi, Thomas Heinze   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Organisational Changes and Psychosocial Work Factors: Prospective Findings From the National French Working Conditions Survey

Safety and Health at Work
The studies exploring the mechanisms by which organisational changes may impact health outcomes are lacking. The objectives of the study were to examine the prospective associations of organisational changes with the deterioration of psychosocial work ...
Isabelle Niedhammer, Sandrine Bertrais
doaj   +1 more source

Crystal structure of phenyl N-(4-nitrophenyl)carbamate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The asymmetric unit of the title compound, C13H10N2O4, contains two independent molecules (A and B). The dihedral angle between the aromatic rings is 48.18 (14)° in molecule A and 45.81 (14)° in molecule B. The mean plane of the carbamate N—C(=O)—O group
Y. AaminaNaaz, Subramaniyan Sathiyaraj, Sundararaj Kalaimani, A. Sultan Nasar, A. SubbiahPandi   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Eat1-Like Alcohol Acyl Transferases From Yeasts Have High Alcoholysis and Thiolysis Activity

Frontiers in Microbiology, 2020
Esters are important flavor and fragrance compounds that are present in many food and beverage products. Many of these esters are produced by yeasts and bacteria during fermentation.
Constantinos Patinios, Constantinos Patinios, Lucrezia Lanza, Inge Corino, Maurice C. R. Franssen, John Van der Oost, Ruud A. Weusthuis, Servé W. M. Kengen   +7 more
doaj   +1 more source