Results 81 to 90 of about 132,817 (351)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Establishing the resistance of Myzus persicae (Sulzer) by molecular methods [PDF]

Archives of Biological Sciences, 2008
In two years of investigating resistance of the peach-potato aphid Myzus persicae (Sulzer) by molecular methods, several types of resistance were established in the majority of individuals from peach and tobacco in Serbia and Montenegro.
Vučetić Anđa, Petrović-Obradović Olivera, Margaritopoulos J., Skouras P.   +3 more
doaj   +1 more source

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Immobilization and characterization of recombinant esterase enzyme on chitosan nanoparticles [PDF]

, 2011
Immobilization of biologically important molecules on myriad nano-sized materials has attracted great attention. Through this study, thermophilic esterase enzyme was obtained using recombinant DNA technology and purified applying one-step His-Select HF ...
Şanlı Mohamed, Gülşah, Şanli-Mohameda, Gülşa, Sanli-Mohamed, Gulsah, Ilgü, Hüseyin, Turan, Taylan   +4 more
core   +1 more source

From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance

Advanced Science, EarlyView.
Lignin serves as both a physical and chemical executor of broad‐spectrum plant immunity. This review systematically summarizes classical and recent advances in lignin‐mediated immunity, outlines the multifaceted regulatory modules controlling lignification under biotic stress, discusses key physiological and biochemical mechanisms behind lignin‐based ...
Yanwen Yu, Ke Wang, Huachuan Tuo, Jiankun Li, Liping Xu, Chang‐Jun Liu, Mingyue Gou   +6 more
wiley   +1 more source

A genetic and demographic investigation of the Zoroastrians of Iran. [PDF]

, 1982
The aim of this study was to examine the Zoroastrians of Yazd, Kerman and Tehran to determine whether or not they differed from each other genetically and from the host population of Iran; to study the Parsis and Iranis - Zoroastrians Who had migrated to
Seyedna, S. Y., Seyedna, S Y.
core  

Esterase inhibition by organo-phosphorus residues, with some observations on possible effects on plant metabolism

, 1955
Organo-phosphorus residues in tissues of sprayed plants were detected by estimating the esterase-inhibiting activity of their leaf and root extracts. This method was used to examine the anti-esterase effects of mangold plants that had been sprayed with ...
Lord, K. A.
core   +1 more source

Scenario of the spread of the invasive species Zaprionus indianus Gupta, 1970 (Diptera, Drosophilidae) in Brazil

Genetics and Molecular Biology, 2010
Zaprionus indianus was first recorded in Brazil in 1999 and rapidly spread throughout the country. We have obtained data on esterase loci polymorphisms (Est2 and Est3), and analyzed them, using Landscape Shape Interpolation and the Monmonier Maximum ...
Luís Gustavo da Conceição Galego, Claudia Marcia Aparecida Carareto   +1 more
doaj  

Wood‐Based Bioelectronics: Lignosulfonate‐Based Conductive Biocomposites for Paper Organic Electrochemical Transistors

Advanced Electronic Materials, EarlyView.
Biodegradable wood‐based bioelectronics are realized by integrating poly (2,3‐ethylenedioxythiopene:lignosulfonate (PEDOT:LigS) as a mixed ionicelectronic channel in organic electrochemical transistors fabricated on paper substrates. The biocomposite exhibits high conductivity, biocompatibility, and strong transistor performance, while devices built on
Katharina Matura, Tobias Grabner, Sarka Hradilova, Munise Cobet, Ariana Opletalova, Katerina Polakova, Alessandra Operamolla, Niyazi Serdar Sariciftci, Serpil Tekoglu   +8 more
wiley   +1 more source