Results 141 to 150 of about 3,026,616 (303)

Methodological Issues in Spatial Microsimulation Modelling for Small Area Estimation [PDF]

open access: yes
In this paper, some vital methodological issues of spatial microsimulation modelling for small area estimation have been addressed, with a particular emphasis given to the reweighting techniques.
Ann Harding   +3 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

On Convergence of the Horn and Schunck

open access: yes, 2008
The purpose of this study is to prove convergence results for the Horn and Schunck optical-flow estimation method. Horn and Schunck stated optical-flow estimation as the minimization of a functional.
Optical-Flow Estimation Method
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Application of combined spatial models for estimation of environmental impact by the power engineering objects of Islamic Republic of Iran

open access: yesВесці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2016
The method of combined space modelling with GIS-technology using for the estimation of environmental effects of energy objects in project, build and work was proposed. The space models for Islamic Republic of Iran energy objects presented.
S. A. Laptyonok   +2 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Small-area estimation with spatial similarity [PDF]

open access: yes
A class of composite estimators of small area quantities that exploit spatial (distancerelated) similarity is derived. It is based on a distribution-free model for the areas, but the estimators are aimed to have optimal design-based properties ...
Nicholas Longford
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Limited Information Estimation and Testing of Discretized Multivariate Normal Structural Models [PDF]

open access: yes
(WP03/03 Clave pdf) We consider the estimation of multivariate normal structural models that have been discretized according to a set of thresholds. A popular estimation procedure for this restricted multinomial model consists in the following three ...
ALBERTO MAYDEU
core  

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