Results 121 to 130 of about 441,851 (391)

Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain.

Endocrinology, 2011
The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant ...
A. Konkle, M. McCarthy
semanticscholar   +1 more source

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

A new method for the separation of androgens from estrogens and for the partition of estriol from the estrone-estradiol fraction: with special reference to the identification and quantitative microdetermination of estrogens by ultraviolet absorption spectrophotometry [PDF]

, 1948
It is recognized generally that a qualitative and quantitative knowledge of the excretion pattern of the urinary estrogens is one index to an understanding of the functional activity of the ovary and adrenal cortex.
Friedgood, Harry B., Garst, Josephine B., Haagen-Smit, A. J.   +2 more
core  

Comprehensive genetic analysis of poorly differentiated gastric cancer in young females

Annals of Gastroenterological Surgery, EarlyView.
Although the involvement of female sex hormones in the development of poorly differentiated gastric cancer in young females is controversial, our detailed analysis using RNA‐seq suggested that the female sex hormone, β‐estradiol plays a role in the development of poorly differentiated gastric cancer in young females. Abstract Aim The reasons behind the
Nobuhiro Nakazawa, Takehiko Yokobori, Yohei Morishita, Akinobu Echigo, Reika Kawabata‐Iwakawa, Akiharu Kimura, Akihiko Sano, Makoto Sakai, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Advances in 3D Printing Technologies for Fabricating Magnetic Soft Microrobots

Advanced Intelligent Systems, EarlyView.
GA: This paper gives an in‐depth synopsis of various additive manufacturing technologies used to fabricate magnetic soft microrobots. The review covers the basics behind magnetism and the materials used. It then dives into three‐dimensional printing technologies including extrusion, photopolymerization, jetting, etc.
Kaitlyn Clancy, Siwen Xie, Onaizah Onaizah   +2 more
wiley   +1 more source

Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses.

Proceedings of the National Academy of Sciences of the United States of America, 1997
On the basis of results of studies using high doses of estrogens, exposure to estrogen during fetal life is known to inhibit prostate development. However, it is recognized in endocrinology that low concentrations of a hormone can stimulate a tissue ...
F. S. Saal, B. Timms, M. Montano, P. Palanza, K. Thayer, S. Nagel, Minati D. Dhar, V. Ganjam, S. Parmigiani, W. Welshons   +9 more
semanticscholar   +1 more source

Compound Heterozygous Variants in ZSWIM7 Gene Linked to Infertility and Its Role in Gonadal Development

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This study aims to elucidate the role of the ZSWIM7 gene in the etiology of infertility, focusing on its potential association with premature ovarian insufficiency and azoospermia. We investigated an 18‐year‐old female patient who presented with primary amenorrhea, hypoplasia of the uterus and ovaries, Tanner stage II breast and pubic hair ...
Denise M. Christofolini, Guilherme Pinn, Thainá Vilella, Maria I. Melaragno, Mariana Moysés‐Oliveira, Luciano Pompei, Rare Genomes Project Consortium, Bianca Bianco, Caio P. Barbosa   +8 more
wiley   +1 more source

Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. [PDF]

, 2019
Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease.
Armirotti, Andrea, Assogna, Francesca, Basit, Abdul, Bossù, Paola, Piomelli, Daniele, Piras, Fabrizio, Realini, Natalia, Sensi, Stefano L, Spalletta, Gianfranco, Vozella, Valentina   +9 more
core   +1 more source

Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density

Journal of Neuroscience, 1997
Previous studies have shown that estradiol induces new dendritic spines and synapses on hippocampal CA1 pyramidal cells. We have assessed the consequences of estradiol-induced dendritic spines on CA1 pyramidal cell intrinsic and synaptic ...
C. Woolley, N. Weiland, B. McEwen, P. Schwartzkroin   +3 more
semanticscholar   +1 more source

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source