Results 121 to 130 of about 309,036 (359)
17β-Estradiol acts separately on the LDL particle and artery wall to reduce LDL accumulation
Journal of Lipid Research, 2000 Estrogen replacement therapy has been shown to attenuate atherogenesis, although the mechanisms for this effect are incompletely defined. Previously, we showed that 17-β estradiol (estradiol) attenuated oxidant stress-induced increases in vascular low ...
Barbara A. Walsh +3 more
doaj
, 2019 Misfolded proteins in the endoplasmic reticulum (ER) activate the unfolded protein response (U PR), which enhances protein folding to restore homeostasis.
Borner, G. +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims The incidence of postmenopausal bleeding (PMB) has been increasing over the past years. Little is known about the risk of PMB after COVID‐19 vaccination. Our study aimed to investigate this based on routine general practitioner (GP) healthcare data from the Netherlands.
Rana Jajou +5 more
wiley +1 more source
Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. [PDF]
, 2019 Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease.
Armirotti, Andrea +9 more
core +1 more source
Estrogen, angiogenesis, immunity and cell metabolism: Solving the puzzle [PDF]
, 2018 Estrogen plays an important role in the regulation of cardiovascular physiology and the immune system by inducing direct effects on multiple cell types including immune and vascular cells. Sex steroid hormones are implicated in cardiovascular protection,
Bolego, Chiara +5 more
core +2 more sources
Drug–drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450
British Journal of Clinical Pharmacology, EarlyView.Aims To assess the effect of a potent cytochrome P450 (CYP) 3A inhibitor and CYP inducer on the pharmacokinetics of ritlecitinib, a JAK3/TEC family kinase inhibitor, and assess the effect of ritlecitinib on the pharmacokinetics of CYP substrates (midazolam, efavirenz, tolbutamide, caffeine and oral contraceptives [ethinyl oestradiol and levonorgestrel])
Vivek S. Purohit +6 more
wiley +1 more source
The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay [PDF]
, 1997 The major protocol features of the immature rat uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the ...
Ashby, J +7 more
core +2 more sources
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay [PDF]
, 2001 Copyright @ 2001 Environmental Health PerspectivesWe used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two
Beresford, NA +3 more
core +2 more sources
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat, EarlyView.The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah +9 more
wiley +1 more source