Results 61 to 70 of about 744,343 (249)

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution

BMC Evolutionary Biology, 2008
Background The origin of nuclear receptors (NRs) and the question whether the ancestral NR was a liganded or an unliganded transcription factor has been recently debated.
Laudet Vincent, Escriva Hector, Pongratz Ingemar, Bertrand Stephanie, Pettersson Katarina, Schubert Michael, Paris Mathilde   +6 more
doaj   +1 more source

Synthesis and estrogenic activity of BODIPY-labeled estradiol conjugates [PDF]

Novel BODIPY-estradiol conjugates have been synthesized by selecting position C-3-O for labeling. The conjugation strategy was based on Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) or etherification.
Laczkó-Rigó Réka, Hetényi Csaba, Peřina Miroslav, Laczka Csilla, Batta Gyula, Vojáčková Veronika, Hlogyik Tamás, Ágoston Henrietta, Börzsei Rita, Poór Miklós, Jorda Radek, Mernyák Erzsébet, Ágoston, Henrietta, Vojáčková, Veronika, Peřina, Miroslav, Börzsei, Rita, Hlogyik, Tamás, Mernyák, Erzsébet, Özvegy-Laczka, Csilla, Poór, Miklós, Batta, Gyula, Hetényi, Csaba, Jorda, Radek, Rigó, Réka   +23 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Studies of the enzymatic synthesis of N-protected amino acid-estradiol derivatives in an organic solvent

, 2000
Amino acid-estradiol derivatives were synthesized via protease-catalyzed condensation for the first time and the optimum conditions were studied systematically.
Yan, AX, Tian, GL, Xing, GW, Wong, MS, Ye, YH, Lee, KS   +5 more
core  

3D model of amphioxus steroid receptor complexed with estradiol [PDF]

, 2009
The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates.
Michael E. Baker, David J. Chang
core  

Synthesis of Chimeric 7α-Substituted Estradiol Derivatives Linked to Cholesterol and Cholesterylamine

, 2016
We report the synthesis of 7α-substituted β-estradiol derivatives bearing side chains terminated with cholesterol and 3β-cholesterylamine. These chimeric compounds were designed to exhibit high affinity for estrogen receptors (ERs) and cellular plasma ...
Enfei He (2987394), Stephen L. Hussey (2987397), Blake R. Peterson (120721)   +2 more
core   +1 more source

TX-004HR vaginal estradiol has negligible to very low systemic absorption of estradiol. [PDF]

, 2016
OBJECTIVE: To evaluate the pharmacokinetics of TX-004HR vaginal estradiol softgel capsules when used for treating moderate-to-severe dyspareunia in postmenopausal women with vulvar and vaginal atrophy.
Mayer, Philip, Archer, David F, Simon, James A, REJOICE Study Group., Bernick, Brian, Mirkin, Sebastian, Kushner, Harvey, Graham, Shelli, Constantine, Ginger D, David F. Archer, James A. Simon, Harvey Kushner, Philip Mayer, Brian Bernick, Sebastian Mirkin, Ginger D. Constantine, Shelli Graham   +16 more
core   +1 more source

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source