Results 71 to 80 of about 744,343 (249)

Comparative Solution Equilibrium Studies on Anticancer Estradiol-Based Conjugates and Their Copper Complexes

Inorganics
Steroids are often considered valuable molecular tools for the development of anticancer agents with improved pharmacological properties. Conjugation of metal chelating moieties with a lipophilic sterane backbone is a viable option to obtain novel ...
Éva A. Enyedy, Anett Giricz, Tatsiana V. Petrasheuskaya, János P. Mészáros, Nóra V. May, Gabriella Spengler, Ferenc Kovács, Barnabás Molnár, Éva Frank   +8 more
doaj   +1 more source

Synthesis and properties of some new 3-substituted hexestrol derivatives

, 1987
A series of new monosubstituted hexestrol derivatives were synthesized and the estrogenic and cytotoxic properties of some of them were studied. 3-Acetoxymethyl-hexestrol 8 has a binding affinity for the cytoplasmic estrogen receptor as high as estradiol.
Vilkas, Michel, Masamba, Luzolo, Makani, Siku, Leclercq, Guy   +3 more
core   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Exploring biomarkers of neurodegenerative risk: associations of oxysterols, sex hormones, and reproductive characteristics in older women

Journal of Lipid Research
Women face a higher lifetime risk of developing neurodegenerative diseases such as Alzheimer’s disease and related dementias. The menopausal transition, characterized by a decline in estrogen levels, may affect cholesterol metabolism and ...
Michelle M. Dunk, Ljerka Delac, Stephen R. Rapp, Ira Driscoll, Maria Latorre-Leal, Leslie V. Farland, Bernhard Haring, Holly R. Harris, Su Yon Jung, JoAnn E. Manson, Heather M. Ochs-Balcom, Aladdin H. Shadyab, Julie C. Weitlauf, Hong Xu, Eric Westman, Silvia Maioli   +15 more
doaj   +1 more source

LncRNA FLJ20021 Restrains Fibroblast Senescence and Matrix Remodeling in Pelvic Organ Prolapse by Promoting XRCC6‐Dependent ADI1 Transcription

Advanced Science, EarlyView.
FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang, BingJie Rui, GuangHai Rui, YiNan Duan, Ji Hyang Kim   +4 more
wiley   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

LncRNA HAND2OT encoding micropeptide regulates the estradiol secretion, proliferation and apoptosis of ovarian follicular theca cells in chickens

Poultry Science
Long non-coding RNAs (lncRNAs) are critical regulators of ovarian follicular development. In chicken ovarian follicles, theca cells are primarily responsible for androgen and estradiol biosynthesis and play an important role in chicken follicular ...
Xinmei Shu, Qingqing Wei, Li Kang, Yi Sun, Yunliang Jiang   +4 more
doaj   +1 more source

Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a key enzyme in the biosynthesis of 17β-estradiol. Novel estrone-based compounds bearing various 15β-oxa-linked substituents and hydroxy, methoxy, benzyloxy, and sulfamate groups in position C3 as ...
Bianka Edina Herman, Anita Kiss, János Wölfling, Erzsébet Mernyák, Mihály Szécsi, Gyula Schneider   +5 more
doaj   +1 more source

17-Alpha-substituted derivatives of estradiol with wound-healing activity

, 2007
The invenlion relates to 17a-(5-hydroxy-C5-hydrocarby])-l,3,5(10)-estratrien-3,17p-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing ...
GAROFALO B, MAGGI A, FILOCAMO, Luigi, MARINI BETTOLO, Rinaldo, MIGNECO, Luisa Maria, JOUDIOUX R, BRUFANI M, CECCACCI, FRANCESCA, ASHCROFT G, FARINA P. M   +9 more
core