Results 91 to 100 of about 996,617 (405)

The roles of estrogen and estrogen receptors in gastrointestinal disease.

Oncology Letters, 2019
Estrogen is an important sex steroid hormone which serves an important role in the regulation of a number of biological functions, including regulating bone density, brain function, cholesterol mobilization, electrolyte balance, skin physiology, the ...
Changmei Chen, Xiang Gong, Xiaoxu Yang, Xianhui Shang, Qian Du, Qiushi Liao, R. Xie, Yuanshou Chen, Jingyu Xu   +8 more
semanticscholar   +1 more source

Functional Integration of Different‐Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis

Advanced Biology, EarlyView.
This study introduces and investigates different‐sex gonad transplants in a mouse model of gender‐affirming hormone therapy. Ovaries and testes implanted into gonadectomized adults exhibit gametogenesis and steroidogenesis independent of the sex of the host.
Daniel R. Pfau, Monica A. Rionda, Evelyn Cho, Jamison G. Clark, Robin E. Kruger, Ruth K. Chan‐Sui, Vasantha Padmanabhan, Molly B. Moravek, Ariella Shikanov   +8 more
wiley   +1 more source

Age and estrogen-associated reductions in hypoxic ventilatory response and chemosensitivity in female rats

Frontiers in Physiology
Respiratory function is modulated by circulating steroid hormones. In female rats, steroid hormones fluctuate across the normal estrous cycle and decline with age, similar to human menopause.
Jessica M. L. Grittner, Rebecca Barok, Edgar Juarez Lopez, Misha Shah, Brendan J. Dougherty   +4 more
doaj   +1 more source

Repurposing the estrogen receptor modulator raloxifene to treat SARS-CoV-2 infection [PDF]

, 2021
Marcello Allegretti, Maria Candida Cesta, Mara Zippoli, Andrea R. Beccari, Carmine Talarico, Flavio Mantelli, Enrico Bucci, Laura Scorzolini, Emanuele Nicastri   +8 more
openalex   +1 more source

The Role of Sex Hormones in Inducing Maternal Uterine Remodeling and Vasodilation During Pregnancy [PDF]

, 2018
Uterine vascular adaptations such as vessel growth and vasodilation are needed to facilitate the more than 10-fold increase of uteroplacental blood flow (UPBF) during pregnancy.
Glessner-Fischer, Annie D.
core   +1 more source

The Zebrafish (Danio rerio) Is a Relevant Model for Studying Sex-Specific Effects of 17β-Estradiol in the Adult Heart [PDF]

, 2019
Cardiovascular diseases are a major cause of morbidity and mortality, and there are significant sex differences therein. However, the underlying mechanisms are poorly understood.
Hassel, David, Hein, Selina, Kararigas, Georgios   +2 more
core   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source

Estrogen Regulates Ca²⁺ to Promote Mitochondrial Function Through G-Protein-Coupled Estrogen Receptors During Oocyte Maturation

Biomolecules
Estrogen is a steroid hormone that plays a key role in regulating many physiological processes, such as follicle activation and development and oocyte maturation in mammals.
Qingyang Liu, Jingmei Li, Yanxue Li, Ming Cheng, Hui Zhang, Baohua Ma   +5 more
doaj   +1 more source

Metoclopramide-Induced Acute Dystonic Reactions May Be Associated With the CYP2D6 Poor Metabolizer Status and Pregnancy-Related Hormonal Changes

Frontiers in Pharmacology, 2019
We report two cases of metoclopramide-induced acute dystonia in pregnant women and consider the role of genetic variation in the pathogenesis of the adverse effect. By whole-gene sequencing, we found that both women were CYP2D6 poor metabolizers.
Eng Wee Chua, Simon P. Harger, Martin A. Kennedy   +2 more
doaj   +1 more source

Estrogen Receptor Functions and Pathways at the Vascular Immune Interface [PDF]

, 2021
Aida Dama, Chiara Baggio, Carlotta Boscaro, Mattia Albiero, Andrea Cignarella   +4 more
openalex   +1 more source