Results 91 to 100 of about 709,941 (344)

Impact of cyclooxygenase inhibitors in the Women's Health Initiative hormone trials: secondary analysis of a randomized trial. [PDF]

, 2006
OBJECTIVES: We evaluated the hypothesis that cyclooxygenase (COX) inhibitor use might have counteracted a beneficial effect of postmenopausal hormone therapy, and account for the absence of cardioprotection in the Women's Health Initiative hormone trials.
Choe, John H, Hsia, Judith, Kuller, Lewis, Langer, Robert D, Limacher, Marian, Manson, Joann E, O'Sullivan, Mary Jo, Oberman, Albert, Ockene, Judith, Pettinger, Mary, Robinson, Jennifer G, Women's Health Initiative Research,   +11 more
core   +3 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Treatment of Girls and Boys with McCune-Albright Syndrome with Precocious Puberty - Update 2017 [PDF]

, 2017
The most common endocrinopathy associated with McCune-Albright Syndrome (MAS) is peripheral precocious puberty (PP) which occurs far more often in girls than in boys.
Eugster, Erica A., Neyman, Anna
core   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers [PDF]

, 2013
Introduction: We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer and inform the choice and length of adjuvant endocrine therapy.
Achim Rody, AJ Minn, Angelica Fasolo, B Haibe-Kains, B Thurlimann, Benjamin Haibe-Kains, C Bellera, C Davies, C Desmedt, C Kim, C Sotiriou, Catherine M Kelly, Christos Sotiriou, CJ van de Velde, D Sgroi, E Amir, G Bianchini, G Bianchini, G Tang, Giampaolo Bianchini, Gianluca Del Conte, H Jin, I Jatoi, JS Parker, KR Hess, KS Albain, Lajos Pusztai, Libero Santarpia, Luca Gianni, M Dowsett, M Filipits, M Schmidt, Marcus Schmidt, Milvia Zambetti, MJ Ellis, MJ van de Vijver, MM Regan, P Dubsky, R Simon, S Loi, S Loi, S Paik, Sven Becker, Takayuki Iwamoto, Thomas Karn, TO Nielsen, Uwe Holtrich, Volkmar Müller, W Fraser Symmans, WF Symmans, WR Miller, Y Wang, Y Zhang, Yuan Qi   +53 more
core   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Treating lupus nephritis patients to lupus low disease activity reduces renal relapse and preserves long‐term kidney function

Arthritis Care &Research, Accepted Article.
Objective Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE) but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment, and its benefit on LN relapse and renal function preservation in patients ...
Chak Kwan Cheung, Desmond YH Yap, KL Lee, Philip H Li, Iris YK Tang, Chak Sing Lau, Shirley CW Chan   +6 more
wiley   +1 more source

Serum levels of 17β-estradiol in ovariectomized rats fed young-coconut-juice and its effect on wound healing [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2006
Exogenous estrogens such as 17β-estradiol (E2) can lower the risk of dementia in postmenopausal women (PMS), but can also increase the risk of serious side effects.
Boonsirm Withyachumnarnkul, Uraporn Vongvatcharanon, Nisaudah Radenahmad, James R. Connor   +3 more
doaj  

Individualized medicine: Sex, hormones, genetics, and adverse drug reactions

Pharmacology Research & Perspectives, 2019
Clinically relevant adverse drug reactions differ between men and women. The underlying physiological and pharmacological processes contributing to these differences are infrequently studied or reported.
Ann M. Moyer, Eric T. Matey, Virginia M. Miller   +2 more
doaj   +1 more source

The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay [PDF]

, 1997
The major protocol features of the immature rat uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the ...
Ashby, J, Beresford, NA, Lefevre, PA, Odum, J, Paton, D, Routledge, EJ, Sumpter, JP, Tittensor, S   +7 more
core   +2 more sources