Results 111 to 120 of about 924,304 (411)

Oscillation patterns in negative feedback loops [PDF]

, 2006
Organisms are equipped with regulatory systems that display a variety of dynamical behaviours ranging from simple stable steady states, to switching and multistability, to oscillations. Earlier work has shown that oscillations in protein concentrations or gene expression levels are related to the presence of at least one negative feedback loop in the ...
arxiv   +1 more source

Mechanisms for estrogen receptor expression in human cancer

Experimental Hematology & Oncology, 2018
Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis.
H. Hua, Hongying Zhang, Qingbin Kong, Yangfu Jiang   +3 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Impact of cyclooxygenase inhibitors in the Women's Health Initiative hormone trials: secondary analysis of a randomized trial. [PDF]

, 2006
OBJECTIVES: We evaluated the hypothesis that cyclooxygenase (COX) inhibitor use might have counteracted a beneficial effect of postmenopausal hormone therapy, and account for the absence of cardioprotection in the Women's Health Initiative hormone trials.
Choe, John H, Hsia, Judith, Kuller, Lewis, Langer, Robert D, Limacher, Marian, Manson, Joann E, O'Sullivan, Mary Jo, Oberman, Albert, Ockene, Judith, Pettinger, Mary, Robinson, Jennifer G, Women's Health Initiative Research,   +11 more
core   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Surgical Menopause and Estrogen Therapy Modulate the Gut Microbiota, Obesity Markers, and Spatial Memory in Rats

Frontiers in Cellular and Infection Microbiology, 2021
Menopause in human females and subsequent ovarian hormone deficiency, particularly concerning 17β-estradiol (E2), increase the risk for metabolic dysfunctions associated with obesity, diabetes type 2, cardiovascular diseases, and dementia.
Lydia Zeibich, Stephanie V. Koebele, Stephanie V. Koebele, Victoria E. Bernaud, Victoria E. Bernaud, Zehra Esra Ilhan, Blake Dirks, Steven N. Northup-Smith, Steven N. Northup-Smith, Rachel Neeley, Rachel Neeley, Juan Maldonado, Juan Maldonado, Khemlal Nirmalkar, Julia A. Files, Anita P. Mayer, Heather A. Bimonte-Nelson, Heather A. Bimonte-Nelson, Rosa Krajmalnik-Brown   +18 more
doaj   +1 more source

The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases

Frontiers in Immunology, 2016
Analogous to other physiological systems, the immune system also demonstrates remarkable sex differences. Although the reasons for sex differences in immune responses are not precisely understood, it potentially involves differences in sex hormones ...
H. Waldmann, S. Ahmed, D. Khan
semanticscholar   +1 more source

No substantial changes in estrogen receptor and estrogen-related receptor orthologue gene transcription in Marisa cornuarietis exposed to estrogenic chemicals [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use ...
Anbalagan, Bannister, David W. Granger, Dietrich, Edwin J. Routledge, Forbes, Giguere, Green, Hall, Hedges, Jobling, Kajiwara, Keay, Kimbrel, Kuiper, Kuiper, Lee, Mariann Rand-Weaver, Medzihradszky, Mueller, Nadine A. Pounds, Nicola Beresford, Oehlmann, Oehlmann, Park, Paulmurugan, Richard Bannister, Roger White, Routledge, Routledge, Schulte-Oehlmann, Stange, Suetsugi, Susan Jobling, Takayanagi, Thornton, Tilghman, Vanacker, Östberg   +38 more
core   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Efficient algorithms for building representative matched pairs with enhanced generalizability [PDF]

arXiv, 2022
Many recent efforts center on assessing the ability of real-world evidence (RWE) generated from non-randomized, observational data to produce results compatible with those from randomized controlled trials (RCTs). One noticeable endeavor is the RCT DUPLICATE initiative (Franklin et al., 2020, 2021).
arxiv