Results 171 to 180 of about 996,617 (405)

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Effects of Estrogen and Progesterone on Behavioral Impairment and Neuronal Death in Ovariectomized Rats Induced by Methamphetamine

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Methamphetamine (METH) is one of the most powerful drugs that leads to many cognitive and behavioral side effects such as anxiety.
Hossein Ghalehnoei, Hamed Ghazvini, Amir Mellati, Seyedeh Masoumeh Seyedhosseini Tamijani, Raheleh Rafaiee, Leila Elyasi, Mehdi Khodamoradi, Ali Siahposht Khachaki, Morteza Hosseini   +8 more
doaj  

Estrogen receptor-beta is a potential target for triple negative breast cancer treatment. [PDF]

, 2018
Triple Negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2.
Austin, David, Elshimali, Yahya, Hamilton, Nalo, Pietras, Richard, Vadgama, Jaydutt, Wu, Yanyuan   +5 more
core   +1 more source

Estrogen receptor signaling mechanisms.

Advances in Protein Chemistry and Structural Biology, 2019
N. Fuentes, P. Silveyra
semanticscholar   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source

Potential Regulation of the Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript1 by Estrogen in Parkinson’s Disease

Life
Parkinson’s disease (PD) is the second-leading cause of death among neurodegenerative disease after Alzheimer’s disease (AD), affecting around 2% of the population. It is expected that the incidence of PD will exceed 12 million by 2040.
Eman Adel, Maya Nicolas
doaj   +1 more source

Quantitative comparisons of in vitro assays for estrogenic activities.

, 2000
Hong Fang, Weida Tong, Roger Perkins, Ana M. Soto, Nancy V. Prechtl, Daniel M. Sheehan   +5 more
openalex   +1 more source

Desensitization of human breast progenitors by a transient exposure to pregnancy levels of estrogen [PDF]

, 2021
Lone Rønnov‐Jessen, Jiyoung Kim, Nadine Goldhammer, Marie Christine Klitgaard, Martynas Smicius, Marc Baker Bechmann, René Villadsen, Ole W. Petersen   +7 more
openalex   +1 more source

Effects of estrogen with and without progestin on urinary incontinence

Journal of family planning and reproductive health care, 2005
L. Melvin
semanticscholar   +1 more source