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Biological Role of Estrogen and Estrogen Receptors

Critical Reviews in Biochemistry and Molecular Biology, 2002
(2002). Biological Role of Estrogen and Estrogen Receptors. Critical Reviews in Biochemistry and Molecular Biology: Vol. 37, No. 1, pp. 1-28.
Stefan, Nilsson, Jan-Ake, Gustafsson
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Estrogen and estrogen receptors in thyroid carcinomas

Journal of Surgical Oncology, 1991
AbstractThyroid tissues, composed of normal thyroid (10 cases), Graves' thyroid (4), and papillary carcinoma (10), were measured for the presence of receptors for estrogen (ER) using an enzyme‐immunoassay method. The mean value of ER in papillary carcinoma tissues (4.0 ± 3.6 fmol/mg protein) was higher than that in normal thyroid tissues (0.8 ± 0.4 ...
Y, Mizukami   +5 more
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Estrogen and estrogen receptors of breast cancer

Journal of Surgical Oncology, 1975
AbstractHuman breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen‐binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment.
V, Sahadevan   +3 more
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Pharmacokinetics of estrogen

International Journal of Gynecology & Obstetrics, 1990
The main types of pharmacologic therapy used to treat the hormone deficiency of menopause are parenteral and oral administrations of estrogen. Parenteral administration results in predictable absorption without major intermediary metabolism, whereas all oral estrogens are subject to intestinal metabolism before entering the systemic circulation ...
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Estrogen or estrogen receptor?

Trends in Endocrinology & Metabolism, 2003
View Large Image | Download PowerPoint SlideAs a clinical breast oncologist, I was eager to review Endocrine Therapy in Breast Cancer. Hormonal manipulation has been the predominant form of breast cancer treatment for >50 years. Surgical ablation, high-dose estrogens, LHRH agonists and antiestrogens have all shown clinical benefit.
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Estrogen Receptors and Anti-Estrogen Therapies

2006
The realisation that breast cancer growth is regulated by the hormone estrogen led to the development of tamoxifen as the first target-directed cancer drug. Clearly, there is considerable headway to be made in further elucidating estrogen receptor function, in particular in identifying the mechanisms underlying endocrine resistance.
Lakjaya, Buluwela   +3 more
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Estrogen and neuroinflammation

Urology, 2001
Women have a higher incidence of inflammatory disorders than men and also appear to perceive painful stimuli differently. It has been suggested that neuroinflammation plays a role in painful bladder disorders of uncertain etiology, such as interstitial cystitis.
D E, Bjorling, Z Y, Wang
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Estrogens in Pregnancy

1978
Publisher Summary This chapter discusses the estrogens in pregnancy. A notable characteristic of normal human pregnancy is the extensive production of a variety of biologically active substances. These include (1) the protein hormones human chorionic gonadotropin and human placental lactogen, (2) the enzymes heat-stable alkaline phosphatase and ...
M, Levitz, B K, Young
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Estrogen, Anti‐Estrogen, and Gender

Annals of the New York Academy of Sciences, 2002
Abstract:In Part 1 of this report, we review data on the effects of estrogen (E), the anti‐E tamoxifen (TMX), and testosterone (T) on methamphetamine (METH)‐induced neurotoxicity in female and male CD‐1 mice. Treatment of gonadectomized females with a physiological regimen of E significantly diminished the amount of striatal dopamine (DA) depletion to ...
Dean E, Dluzen, Janet L, McDermott
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Estrogens as neuromodulators

Aging Clinical and Experimental Research, 1997
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Petraglia, F   +5 more
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