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Estrogens and Development [PDF]

Environmental Health Perspectives, 1987
The normal development of the genital organs of mammals, including humans, is under hormonal control. A role for the female sex hormone estrogen in this process is still unclear. However, exposure of experimental animals or humans to the potent exogenous estrogen, diethylstilbestrol (DES), results in persistent differentiation effects.
John A. McLachlan, Retha R. Newbold
openaire   +4 more sources

A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]

, 2018
Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A., Frick, Karyn M., Hanson, Alicia M., Imhoff, Andrea, Kim, Jaekyoon, Lu, Xingyun, Mackinnon, Alexander Craig, Pandey, Rajesh K., Perera, K. L. Iresha Sampathi, Sem, Daniel S., Sweeney, Noreena, Van Hart, Rochelle M., Wargolet, Adam J.   +12 more
core   +4 more sources

Sex Differences in Memory: Do Female Reproductive Factors Explain the Differences?

Frontiers in Endocrinology, 2022
BackgroundThe sex differences in memory impairment were inconclusive, and the effect of female reproductive factors (age at menarche, age at menopause, and reproductive period) on the differences was not clear.
Jie Li, Jie Li, Wenting Hao, Wenting Hao, Chunying Fu, Chunying Fu, Chengchao Zhou, Chengchao Zhou, Dongshan Zhu, Dongshan Zhu, Dongshan Zhu   +10 more
doaj   +1 more source

The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

Biology of Sex Differences, 2017
Epidemiologic studies have previously suggested that premenopausal females have reduced incidence of cardiovascular disease (CVD) when compared to age-matched males, and the incidence and severity of CVD increases postmenopause.
Andrea Iorga, C. Cunningham, S. Moazeni, G. Ruffenach, S. Umar, M. Eghbali   +5 more
semanticscholar   +1 more source

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?

International Journal of Molecular Sciences, 2019
In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptivity.
R. Marquardt, Tae Hoon Kim, Jung-Ho Shin, Jae-Wook Jeong   +3 more
semanticscholar   +1 more source

Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin [PDF]

, 2010
Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes.
Albini, Adriana, Bachmeier, Beatrice E., Blengio, Fabiola, Dell'Eva, Raffaella, Esposito, Alessia, Generoso, Luca, Killian, Peter H., Mirisola, Valentina, Pfeffer, Ulrich, Romeo, Francesco   +9 more
core   +1 more source

Association between sex steroid hormones and subsequent hyperglycemia during pregnancy

Frontiers in Endocrinology, 2023
ObjectiveSex steroid hormones may play a role in insulin resistance and glucose dysregulation. However, evidence regarding associations between early-pregnancy sex steroid hormones and hyperglycemia during pregnancy is limited.
Ying Meng, Loralei L. Thornburg, Kathleen M. Hoeger, Zorimar Rivera- Núñez, Zorimar Rivera- Núñez, Amber Kautz, Adam T. Evans, Christina Wang, Richard K. Miller, Susan W. Groth, Thomas G. O’Connor, Thomas G. O’Connor, Thomas G. O’Connor, Thomas G. O’Connor, Emily S. Barrett, Emily S. Barrett, Emily S. Barrett, Emily S. Barrett   +17 more
doaj   +1 more source

Estrogens and the kidney

Kidney International, 1974
This paper presents a review of the major anatomical, biochemical and physiological effects of estrogens upon the kidney. The field awaits a careful, systematic and comprehensive study.
Nicholas P. Christy, Joyce C. Shaver
openaire   +3 more sources

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo, Jae-Hyun Park, Jung-Won Kim, Meng-Lay Lin, Miki Akiyama, Tatsuhiko Tsunoda, Tomomi Ueki, Toshihiko Nishidate, Toyomasa Katagiri, Yataro Daigo, Yusuke Nakamura   +10 more
core   +2 more sources