Tissue Specific Effects of Loss of Estrogen During Menopause and Aging
The roles of estrogens have been best studied in the breast, breast cancers and in the female reproductive tract. However, estrogens have important functions in almost every tissue in the body. Recent clinical trials such as the Women’s Health Initiative
Korinna eWend, Peter eWend, Susan A Krum
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The following article presents results of the complex research on postulation of immunohistochemical features of the ovaries’ structure in case of fetuses with a gestational term of 21-28 weeks from mothers with HILGT comparing to ones in case of fetuses
V. O. Poliyasnyi, L. S. Kupriianova
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Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine. [PDF]
Background— Experimental evidence suggests that estrogens stimulate the production of nitric oxide (NO) by vascular endothelial cells. This effect has been attributed to increased expression and enzymatic activity of both the constitutive and inducible ...
Cartwright, JE +7 more
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Sex Differences in Memory: Do Female Reproductive Factors Explain the Differences?
BackgroundThe sex differences in memory impairment were inconclusive, and the effect of female reproductive factors (age at menarche, age at menopause, and reproductive period) on the differences was not clear.
Jie Li +10 more
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Molecular mechanism of estrogen–estrogen receptor signaling [PDF]
Abstract17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes.
Yasar, Pelin +4 more
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Association between sex steroid hormones and subsequent hyperglycemia during pregnancy
ObjectiveSex steroid hormones may play a role in insulin resistance and glucose dysregulation. However, evidence regarding associations between early-pregnancy sex steroid hormones and hyperglycemia during pregnancy is limited.
Ying Meng +17 more
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Estrogen receptor as the predictive factor for response to chemotherapy in breast cancer [PDF]
It has generally been accepted that breast cancer (BC) cells are equally responsive to chemotherapy (CHT) irrespective of ER status. However, subset analyses of disease outcome in recently reported trials on neoadjuvant and adjuvant CHT brought new ...
Šušnjar Snežana +1 more
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Estrogenic Activities in Rodent Estrogen-Free Diets [PDF]
Diets lacking soy and alpha-alpha derivatives that are considered to be estrogen-free by standard bioassays (uterotrophic assay and vaginal opening) have been revealed to contain considerable amounts of compounds able to transcriptionally activate the estrogen receptors (ERs) and stimulate luciferase expression in several organs of the ERE-Luc reporter
P. Ciana +5 more
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Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer [PDF]
Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may ...
Liang, Liang +29 more
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Developmental Effects of Prenatal Exposure to Bisphenol A on the Uterus of Rat Offspring
Exposure to estrogenic compounds during critical periods of fetal development could result in adverse effects on the development of reproductive organs that are not apparent until later in life.
Gilbert Schönfelder +3 more
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