KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function [PDF]
, 2018 Estrogen receptor alpha (ER alpha) is a ligand-activated nuclear receptor that directs proliferation and differentiation in selected cancer cell types including mammary-derived carcinomas.
Abdel-Wahab, Omar +13 more
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Estrogen Signaling via Estrogen Receptor β [PDF]
Journal of Biological Chemistry, 2010 Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ. Transcriptional regulation by ERs is controlled by a complex array of factors such as ER-ligand binding, the DNA sequence bound by ERs, ER-interacting cofactors, and chromatin context.
Chunyan, Zhao +2 more
openaire +2 more sources
Developmental Effects of Prenatal Exposure to Bisphenol A on the Uterus of Rat Offspring
Neoplasia: An International Journal for Oncology Research, 2004 Exposure to estrogenic compounds during critical periods of fetal development could result in adverse effects on the development of reproductive organs that are not apparent until later in life.
Gilbert Schönfelder +3 more
doaj +1 more source
Estrogen receptor as the predictive factor for response to chemotherapy in breast cancer [PDF]
Archive of Oncology, 2006 It has generally been accepted that breast cancer (BC) cells are equally responsive to chemotherapy (CHT) irrespective of ER status. However, subset analyses of disease outcome in recently reported trials on neoadjuvant and adjuvant CHT brought new ...
Šušnjar Snežana +1 more
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Metformin reverses development of pulmonary hypertension via aromatase inhibition [PDF]
, 2016 Females are more susceptible to pulmonary arterial hypertension than males, although the reasons remain unclear. The hypoglycemic drug, metformin, is reported to have multiple actions, including the inhibition of aromatase and stimulation of AMP ...
Dean, Afshan +4 more
core +2 more sources
Estrogen-Independent Activation of Estrogen Receptors [PDF]
Hypertension, 2011 See related article, pp 1161–1166 Sex differences showing a lower prevalence and better outcome after ischemic stroke in women have been described, differences that are abrogated by natural or surgical menopause.1,2 High levels of endogenous estrogens in premenopausal women have been associated with reduced risk for a number of diseases, such as ...
Matthias, Barton +2 more
openaire +2 more sources
Evolutionary insights into the steroid sensitive kiss1 and kiss2 neurons in the vertebrate brain
Frontiers in Endocrinology, 2012 Kisspeptin was originally found as a peptide product of Kiss1gene and is now supposed to be an essential central regulator of reproduction in mammals. However, there is now a growing body of evidence to suggest that kiss2, the paralogous gene for kiss1 ...
Shinji eKanda, Yoshitaka eOka
doaj +1 more source
Hysterectomy for Benign Indications and Risk of Cataract Formation in South Korean Women
Medicina, 2023 Background and Objectives: Few studies have investigated the relationship between female reproductive hormones, especially estrogen, and the incidence of cataracts.
Jae Suk Kim
doaj +1 more source
Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]
, 2009 Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo +10 more
core +2 more sources
Molecules, 2023 Estradiol (E2) plays an important role in the progression of diseases such as breast cancer and endometriosis. Inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), the enzyme that catalyzes the last step in the biosynthesis of the estrogenic
Adrien Djiemeny Ngueta +3 more
doaj +1 more source