Results 41 to 50 of about 259,511 (121)

Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions

Hormones & cancer, 2019
Endometrial cancer is the most common gynecological cancer in the developed world, and it is one of the few cancer types that is becoming more prevalent and leading to more deaths in the USA each year. The majority of endometrial tumors are considered to
Adriana C. Rodriguez, Zannel Blanchard, K. Maurer, Jason Gertz   +3 more
semanticscholar   +1 more source

Dual-path convolutional neural network using micro-FTIR imaging to predict breast cancer subtypes and biomarkers levels: estrogen receptor, progesterone receptor, HER2 and Ki67 [PDF]

arXiv, 2023
Breast cancer molecular subtypes classification plays an import role to sort patients with divergent prognosis. The biomarkers used are Estrogen Receptor (ER), Progesterone Receptor (PR), HER2, and Ki67. Based on these biomarkers expression levels, subtypes are classified as Luminal A (LA), Luminal B (LB), HER2 subtype, and Triple-Negative Breast ...
arxiv  

Identifying short motifs by means of extreme value analysis [PDF]

Europhysics Letters 84 18001 (2008), 2008
The problem of detecting a binding site -- a substring of DNA where transcription factors attach -- on a long DNA sequence requires the recognition of a small pattern in a large background. For short binding sites, the matching probability can display large fluctuations from one putative binding site to another.
arxiv   +1 more source

The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages

Frontiers in Immunology, 2018
Inflammation is regulated by many endogenous factors including estrogen, a steroid hormone that declines with increasing age, leading to excessive inflammation in the elderly. C-reactive protein (CRP) is an acute phase inflammatory protein that exists in
Nicola R. Sproston, Mohamed El Mohtadi, Mark Slevin, William Gilmore, Jason J. Ashworth   +4 more
doaj   +1 more source

Estrogen Deficiency Induces Mitochondrial Damage Prior to Emergence of Cognitive Deficits in a Postmenopausal Mouse Model

Frontiers in Aging Neuroscience, 2021
Background: Estrogen deficiency contributes to the development of Alzheimer’s disease (AD) in menopausal women. In the current study, we examined the impact of estrogen deficiency on mitochondrial function and cognition using a postmenopausal mouse model.
Wei Zhao, Yue Hou, Xinxin Song, Lei Wang, Fangfang Zhang, Hanting Zhang, Haiyang Yu, Yanmeng Zhou   +7 more
doaj   +1 more source

Update on the Role of Neuropeptide Y and Other Related Factors in Breast Cancer and Osteoporosis

Frontiers in Endocrinology, 2021
Breast cancer and osteoporosis are common diseases that affect the survival and quality of life in postmenopausal women. Women with breast cancer are more likely to develop osteoporosis than women without breast cancer due to certain factors that can ...
Shu-ting Lin, Yi-zhong Li, Xiao-qi Sun, Qian-qian Chen, Shun-fa Huang, Shu Lin, Shu Lin, Si-qing Cai   +7 more
doaj   +1 more source

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Annual Review of Clinical Psychology, 2019
This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women.
Kimberly M Albert, P. Newhouse
semanticscholar   +1 more source

Importance of P53, Ki-67 expression in the differential diagnosis of benign/malignant phyllodes tumors of the breast

Indian Journal of Pathology and Microbiology, 2013
Background: Conventionally growth pattern, stromal overgrowth, stromal cellularity and stromal mitotic activity are the main parameters in the grading of phyllodes tumors (PTs).
Ulku Kucuk, Umit Bayol, Emel Ebru Pala, Suheyla Cumurcu   +3 more
doaj   +1 more source

FMO Interaction Energy between 17$β$-Estradiol, 17$α$-Estradiol and Human Estrogen Receptor $α$ [PDF]

arXiv, 2020
The estrogen receptor is a nuclear hormone receptor activated by the natural steroid hormone 17$\beta$-estradiol (E2). Fragment molecular orbital (FMO) calculations were performed which allowed us to obtain the interaction energy ($E_{int}$) between E2, 17$\alpha$-estradiol (17$\alpha$-E2) and the human estrogen receptor $\alpha$ ligand-binding domain.
arxiv  

Prognostic role of GPER/Ezrin in triple-negative breast cancer is associated with menopausal status

Endocrine Connections, 2019
The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC).
Shuang Ye, Yuanyuan Xu, Jiehao Li, Shuhui Zheng, Peng Sun, Tinghuai Wang   +5 more
doaj   +1 more source