Results 61 to 70 of about 712,236 (344)

Prognostic role of GPER/Ezrin in triple-negative breast cancer is associated with menopausal status

Endocrine Connections, 2019
The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC).
Shuang Ye, Yuanyuan Xu, Jiehao Li, Shuhui Zheng, Peng Sun, Tinghuai Wang   +5 more
doaj   +1 more source

TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and Network Study

Frontiers in Endocrinology, 2021
BackgroundWomen who undergo chronic exposure to excessive estrogen are at a high risk of developing breast cancer. TOX3 has been reported to be highly expressed in breast tumors and is closely related to estrogen receptors. However, the effect of TOX3 on
Yuanyuan Man, Yuanyuan Man, Yuanyuan Man, Yuanyuan Man, Yuanyuan Man, Rusong Zhao, Rusong Zhao, Rusong Zhao, Rusong Zhao, Rusong Zhao, Xueying Gao, Xueying Gao, Xueying Gao, Xueying Gao, Xueying Gao, Yue Liu, Yue Liu, Yue Liu, Yue Liu, Yue Liu, Shigang Zhao, Shigang Zhao, Shigang Zhao, Shigang Zhao, Shigang Zhao, Gang Lu, Wai-Yee Chan, Peter C. K. Leung, Yuehong Bian, Yuehong Bian, Yuehong Bian, Yuehong Bian, Yuehong Bian   +32 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Estrogen receptor-α gene, codon 594 (G3242A) polymorphism among Iranian women with breast cancer: a case control study [PDF]

, 2009
A case-control study was conducted to establish a database of ESR1 polymorphisms in Iranian population in order to compare Western and Iranian (Middle East) distributions and to evaluate ESR1 polymorphism as an indicator of clinical outcome.
Abbasi, Sakineh, Azimi, Cyrus, Ismail, Patimah, Othman, Fauziah, Rosli, Rozita   +4 more
core   +1 more source

Role of Sex in the Therapeutic Targeting of p53 Circuitry

Frontiers in Oncology, 2021
Sex profoundly affects cancer incidence and susceptibility to therapy, with sex hormones highly contributing to this disparity. Various studies and omics data suggest a relationship between sex and the oncosuppressor p53 circuitry, including its ...
Francesca Mancini, Ludovica Giorgini, Ludovica Giorgini, Emanuela Teveroni, Alfredo Pontecorvi, Fabiola Moretti   +5 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption [PDF]

, 2011
In the last decade, there has been important progress in understanding the origins and evolution of receptors for adrenal steroids (aldosterone, cortisol) and sex steroids (estradiol, progesterone, testosterone) due to the sequencing of genomes from ...
Michael E. Baker
core   +2 more sources

Daily and Estral Regulation of RFRP-3 Neurons in the Female Mice

Journal of Circadian Rhythms, 2021
Female reproductive success relies on proper integration of circadian- and ovarian- signals to the hypothalamic-pituitary-gonadal axis in order to synchronize the preovulatory LH surge at the end of the ovarian follicular stage with the onset of the main
Eleni Angelopoulou, Perrine Inquimbert, Paul Klosen, Greg Anderson, Andries Kalsbeek, Valérie Simonneaux   +5 more
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Addition of anti-estrogen therapy to anti-HER2 dendritic cell vaccination improves regional nodal immune response and pathologic complete response rate in patients with ERpos/HER2pos early breast cancer

OncoImmunology, 2017
HER2-directed therapies are less effective in patients with ERpos compared to ERneg breast cancer, possibly reflecting bidirectional activation between HER2 and estrogen signaling pathways.
Lea Lowenfeld, Salman Zaheer, Crystal Oechsle, Megan Fracol, Jashodeep Datta, Shuwen Xu, Elizabeth Fitzpatrick, Robert E. Roses, Carla S. Fisher, Elizabeth S. McDonald, Paul J. Zhang, Angela DeMichele, Rosemarie Mick, Gary K. Koski, Brian J. Czerniecki   +14 more
doaj   +1 more source