Results 71 to 80 of about 919,146 (322)

Impact of microbiota on breast cancer hormone therapy

Cell Stress, 2023
Recent observations indicate that the pathogenesis and prognosis of hormone-receptor breast cancer is not only dictated by the properties of the malignant cells but also by immune and microbial parameters.
Safae Terrisse, Laurence Zitvogel, Guido Kroemer   +2 more
doaj   +1 more source

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2017
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co ...
Indarto, Dono, Izawa, Masao
core  

Identification of putative steroid receptor antagonists in bottled water : combining bioassays and high-resolution mass spectrometry

, 2013
Endocrine disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling and thereby adversely affecting human health. Recent reports provide evidence for the presence of EDCs in commercially available bottled water, including ...
Michael P Schlüsener, Thomas A. Ternes (74117), Schlüsener, Michael P., Jörg Oehlmann, Thomas A Ternes, Martin Wagner (72668), Oehlmann, Jörg, Jörg Oehlmann (74061), Michael P. Schlüsener (451380), Martin Wagner, Wagner, Martin, Ternes, Thomas A.   +11 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Characterization of Estrogenic and Androgenic Activities for Bisphenol A-like Chemicals (BPs): In Vitro Estrogen and Androgen Receptors Transcriptional Activation, Gene Regulation, and Binding Profiles.

Toxicological Sciences, 2019
Bisphenol A (BPA) is a high production volume chemical widely used in plastics, food packaging, and many other products. It is well known that endocrine-disrupting chemicals (EDC) might be harmful to human health due to interference with normal hormone ...
Katherine E. Pelch, Yin Li, L. Perera, K. Thayer, K. Korach   +4 more
semanticscholar   +1 more source

Estrogen receptor α antagonists mediate changes in CCL20 and CXCL1 secretions in the murine female reproductive tract

, 2013
PROBLEM\ud \ud Estradiol regulates chemokine secretion from uterine epithelial cells, but little is known about estradiol regulation in vivo or the role of estrogen receptors (ERs).\ud \ud METHOD\ud \ud CCL20 and CXCL1 present in reproductive washes ...
Hickey, Danica K., Fahey, John V., Wira, Charles R.   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Antiestrógenos: mecanismo de acción y aplicaciones clínicas Antiestrogens: mechanism of action and clinical applications

Salud Pública de México, 2001
Los antiestrógenos son compuestos que antagonizan la acción de los estrógenos compitiendo por su receptor. Los estrógenos están implicados en la proliferación y diferenciación de las células blanco y se consideran entre los principales factores de riesgo
Arturo Barrón-González, Joel Arias-Martínez, Ivone Castro-Romero   +2 more
doaj  

The Estrogen Receptor Is Not Essential for All Estrogen Neuroprotection: New Evidence from a New Analog

Neurobiology of Disease, 2002
We synthesized an estrogen analog, ZYC-5, lacking activity at the classical estrogen receptor and examined its neuroprotective potential against necrosis induced by N-methyl-d-aspartate (NMDA) and apoptosis/necrosis induced by the NMDA receptor ...
Shuli Xia, Zu Yun Cai, Liu Lin Thio, Jeong Sook Kim-Han, Laura L. Dugan, Douglas F. Covey, Steven M. Rothman   +6 more
doaj   +1 more source

ESR1 mutation as an emerging clinical biomarker in metastatic hormone receptor-positive breast cancer

Breast Cancer Research, 2021
In metastatic hormone receptor-positive breast cancer, ESR1 mutations are a common cause of acquired resistance to the backbone of therapy, estrogen deprivation by aromatase inhibition.
Jamie O. Brett, Laura M. Spring, Aditya Bardia, Seth A. Wander   +3 more
doaj   +1 more source