Results 91 to 100 of about 276,776 (266)

Shell formation and bone strength in laying hens [PDF]

, 2013
In Sweden almost 3.8% of all eggs are ruined due to cracked eggshells as shell quality declines with age during the laying period. This is a concern for food safety as well as an economical problem.
Wistedt, Anna
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PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Anterior prostate epithelial AR inactivation modifies estrogen receptor expression and increases estrogen sensitivity

, 2011
*This article is free to read on the publisher's website* \ud \ud Androgens influence prostate growth and development, so androgen withdrawal can control progression of prostate diseases. Although estrogen treatment was originally used to induce androgen
Handelsman, David, McNamara, Keely, Jimenez, Mark, Desai, Reena, Ulla Simanainen, David J. Handelsman, Simanainen, Ulla, Mark Jimenez, Gao, Yan Ru, McPherson, Stephen, Keely McNamara, Stephen McPherson, Yan Ru Gao, Reena Desai   +13 more
core   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals

, 1999
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens,
Andersson, AM, McLachlan, J, Steven F. Arnold, Arnold, SF, Philippe Grandjean, Andersen, HR, John P. Sumpter, Autrup, H, Henrik Leffers, Eva Bonefeld Jørgensen, Leffers, H, Ana M. Soto, Moller, A, Hummel, R, Oles-Karasko, A, Susan M. Thorpe, Beresford, NA, Perez, P, Thorpe, SM, Marianne Barfoed, Remy Le Guevel, Anette Møller, Nielsen, JB, Pakdel, F, Knud L. Pedersen, Pilar Perez, Christiansen, LB, Herman Autrup, Anita Oles-Karasko, Nicola A. Beresford, John McLachlan, Nicolas Olea, Skakkeboek, NE, Birgitte Gissel, Pedersen, KL, Korsgaard, B, Le Guevel, R, Grandjean, P, Lisette B. Christiansen, Bodil Korsgaard, Carlos Sonnenschein, Barfoed, M, Barfoed, N, Farzad Pakdel, René Hummel, Helle Raun Andersen, Gissel, B, Poul Bjerregaard, Bjerregaard, P, Soto, AM, Niels Erik Skakkebœk, Olea, N, Sumpter, JP, Anna-Maria Andersson, Jesper Bo Nielsen, Jorgensen, EB, Sonnenschein, C   +56 more
core   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Estrogen receptor ligands counteract cognitive deficits caused by androgen deprivation in male rats

, 2011
Androgen deprivation causes impairment of cognitive tasks in rodents and humans, and this deficit can be reverted by androgen replacement therapy. Part of the effects of androgens in the male may be mediated by their local metabolism to estradiol or 3 ...
García-Segura, Luis M., Calmarza-Font, Isabel, Natalia Lagunas, Luis M. Garcia-Segura, Lagunas García, Luisa Natalia, Grassi, Daniela, Isabel Calmarza-Font, Garcia-Segura, Luis, Lagunas, Natalia, Daniela Grassi   +9 more
core   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Update on bazedoxifene: A novel selective estrogen receptor modulator

, 2007
Diane M BiskobingDepartment of Medicine, Virginia Commonwealth University, Richmond, VA, USAAbstract: In the elderly population, osteoporosis is a significant clinical problem leading to disability and even death.
Diane M Biskobing
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