Results 91 to 100 of about 1,539,304 (263)

T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers [PDF]

, 2009
Introduction: Lymphocyte infiltration (LI) is often seen in breast cancer but its importance remains controversial. A positive correlation of human epidermal growth factor receptor 2 (HER2) amplification and LI has been described, which was associated ...
Pusztai, Laos, Solbach, Christine, Ahr, André, Karn, Thomas, Liedtke, Cornelia, Gätje, Regine, Hanker, Lars, Holtrich, Uwe, Gaetje, Regine, Rody, Achim, Ruckhäberle, Eugen, Metzler, Dirk, Ruckhaeberle, Eugen, Engels, Knut, Kaufmann, Manfred   +14 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

PPFIA1 is upregulated in liver metastasis of breast cancer and is a potential poor prognostic indicator of metastatic relapse

Tumor Biology, 2017
Although the oncogenic role of PPFIA1 (liprin-α1) in breast cancer has been reported, whether its dysregulation is associated with metastasis risk or survival outcomes in breast cancer patients is not clear. Our primary data showed that PPFIA1 expression
Jing Yang, Ning-Ni Wu, De-Jia Huang, Yao-Chang Luo, Jun-Zhen Huang, Hai-Yuan He, Hai-Lin Lu, Wen-Ling Song   +7 more
doaj   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals [PDF]

, 1999
The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens,
Andersson, AM, McLachlan, J, Steven F. Arnold, Arnold, SF, Philippe Grandjean, Andersen, HR, John P. Sumpter, Autrup, H, Henrik Leffers, Eva Bonefeld Jørgensen, Leffers, H, Ana M. Soto, Moller, A, Hummel, R, Oles-Karasko, A, Susan M. Thorpe, Beresford, NA, Perez, P, Thorpe, SM, Marianne Barfoed, Remy Le Guevel, Anette Møller, Nielsen, JB, Pakdel, F, Knud L. Pedersen, Pilar Perez, Christiansen, LB, Herman Autrup, Anita Oles-Karasko, Nicola A. Beresford, John McLachlan, Nicolas Olea, Skakkeboek, NE, Birgitte Gissel, Pedersen, KL, Korsgaard, B, Le Guevel, R, Grandjean, P, Lisette B. Christiansen, Bodil Korsgaard, Carlos Sonnenschein, Barfoed, M, Barfoed, N, Farzad Pakdel, René Hummel, Helle Raun Andersen, Gissel, B, Poul Bjerregaard, Bjerregaard, P, Soto, AM, Niels Erik Skakkebœk, Olea, N, Sumpter, JP, Anna-Maria Andersson, Jesper Bo Nielsen, Jorgensen, EB, Sonnenschein, C   +56 more
core   +2 more sources

Rational modification of estrogen receptor by combination of computational and experimental analysis.

PLoS ONE, 2014
In this manuscript, we modulate the binding properties of estrogen receptor protein by rationally modifying the amino acid composition of its ligand binding domain. By combining sequence alignment and structural analysis of known estrogen receptor-ligand
Valentina Elisabetta Viviana Ferrero, Mattia Pedotti, Alessandro Chiadò, Luca Simonelli, Luigi Calzolai, Luca Varani, Teresa Lettieri   +6 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats [PDF]

, 2019
The ovarian hormone 17β-estradiol is known to regulate the release, expression and immunoreactivity of arginine-vasopressin (AVP) in the supraoptic and paraventricular hypothalamic nuclei of rodents.
Collado, Paloma, Panzica, Giancarlo, Marraudino, Marilena, Amorim, Miguel de, Pinos, Helena, Lagunas García, Luisa Natalia, García Segura, L. M., Grassi, Daniela, Garcia-Segura, Luis   +8 more
core   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Second-site inhibitors of the estrogen and androgen hormone receptors [PDF]

, 2011
The estrogen and androgen receptors are members of the nuclear hormone receptor protein superfamily and play an important role in the development of primary and secondary female and male sexual characteristics.
Parent, Alexander A.
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