Results 101 to 110 of about 2,614,131 (297)

Estrogen receptor immunocytochemistry. [PDF]

Journal of Histochemistry & Cytochemistry, 1978
Estrogen receptor activity was preserved in fixed, paraffin-embedded tissue and demonstrated by binding of estrogen which, in turn, was detected immunocytochemically. Estrogen was added to rat endocervial epithelium to protect specifically receptors during fixation.
Ludwig A. Sternberger, Robert M. Kurzon
openaire   +3 more sources

Novel developments in the study of estrogen in the pathogenesis and therapeutic intervention of lymphangioleiomyomatosis

Orphanet Journal of Rare Diseases
Objective This study aimed to enhance the understanding of the role of estrogen in lymphangioleiomyomatosis(LAM) and to conclude the impact of estrogen-altering events on the condition and recent advances in estrogen-based treatments for LAM. Results LAM
Jingye Tai, Shihua Liu, Xinping Yan, Luantai Huang, Yingxin Pan, Hongyuan Huang, Zhen Zhao, Beini Xu, Jie Liu   +8 more
doaj   +1 more source

Estrogen alpha receptor antagonists for the treatment of breast cancer: a review

Chemistry Central Journal, 2018
Background Cancer is at present one of the leading causes of death in the world. It accounts for 13% of deaths occurred worldwide and is continuously rising, with an estimated million of deaths up to 2030.
Deepika Sharma, Sanjiv Kumar, Balasubramanian Narasimhan   +2 more
doaj   +1 more source

Mechanisms associated with resistance to tamoxifen in estrogen receptor-positive breast cancer (review).

Oncology Report, 2014
Anti-estrogens such as tamoxifen are widely used in the clinic to treat estrogen receptor-positive breast tumors. Patients with estrogen receptor-positive breast cancer initially respond to treatment with anti-hormonal agents such as tamoxifen, but ...
Rubí Viedma-Rodríguez, L. Baiza-Gutman, F. Salamanca-Gómez, Mariana Diaz-Zaragoza, Guadalupe Martínez-Hernández, R. Ruiz Esparza-Garrido, M. Velázquez-Flores, D. Arenas-Aranda   +7 more
semanticscholar   +1 more source

HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women

Breast Cancer Research, 2018
Background The sensitivity of estrogen receptor-positive breast cancers to tamoxifen treatment varies considerably, and the molecular mechanisms affecting the response rates are manifold.
Anja Kathrin Wege, Dominik Chittka, Stefan Buchholz, Monika Klinkhammer-Schalke, Simone Diermeier-Daucher, Florian Zeman, Olaf Ortmann, Gero Brockhoff   +7 more
doaj   +1 more source

Computational Estimates of Binding Affinities for Estrogen Receptor Isoforms in Rainbow Trout [PDF]

arXiv, 2009
Molecular dynamics simulations were used to determine the binding affinities between between the hormone 17 beta-estradiol (E2) and different estrogen receptor (ER) isoforms in the rainbow trout, Oncorhynchus mykiss. Previous phylogenetic analysis indicates that a whole genome duplication prior to the divergence of ray-finned fish led to two distinct ...
arxiv  

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.

Molecular Endocrinology, 2000
Estrogen rapidly activates the mitogen-activated protein kinases, Erk-1 and Erk-2, via an as yet unknown mechanism. Here, evidence is provided that estrogen-induced Erk-1/-2 activation occurs independently of known estrogen receptors, but requires the ...
E. Filardo, Jeffrey A. Quinn, K. Bland, A. Frackelton, Roger Williams   +4 more
semanticscholar   +1 more source

Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells

Tumor Biology, 2017
Human testis, gonocytes, and adult germ cells mainly express estrogen receptor beta, and estrogen receptor beta loss is associated with advanced tumor stage; however, the molecular mechanisms of estrogen receptor beta–protective effects are still to be ...
Salvatore Panza, Marta Santoro, Francesca De Amicis, Catia Morelli, Valentina Passarelli, Patrizia D’Aquila, Francesca Giordano, Erika Cione, Giuseppe Passarino, Dina Bellizzi, Saveria Aquila   +10 more
doaj   +1 more source

Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes.

Molecular Endocrinology, 2005
Estrogen receptors (ERs) act by regulating transcriptional processes. The classical mechanism of ER action involves estrogen binding to receptors in the nucleus, after which the receptors dimerize and bind to specific response elements known as estrogen ...
L. Björnström, M. Sjöberg
semanticscholar   +1 more source

PPFIA1 is upregulated in liver metastasis of breast cancer and is a potential poor prognostic indicator of metastatic relapse

Tumor Biology, 2017
Although the oncogenic role of PPFIA1 (liprin-α1) in breast cancer has been reported, whether its dysregulation is associated with metastasis risk or survival outcomes in breast cancer patients is not clear. Our primary data showed that PPFIA1 expression
Jing Yang, Ning-Ni Wu, De-Jia Huang, Yao-Chang Luo, Jun-Zhen Huang, Hai-Yuan He, Hai-Lin Lu, Wen-Ling Song   +7 more
doaj   +1 more source