Results 111 to 120 of about 2,614,131 (297)
Exploiting synthetic lethal vulnerabilities for cancer therapy [PDF]
arXiv, 2016 Synthetic lethality refers to a combination of two or more genetic events (typically affecting different genes) in which the co-occurrence of the events results in cell or organismal lethality, but the cell or organism remains viable when only one of the events occurs.
arxiv
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.
Endocrinology, 2005 Although nonclassical estrogen actions initiated at the cell surface have been described in many tissues, the identities of the membrane estrogen receptors (mERs) mediating these actions remain unclear.
P. Thomas +3 more
semanticscholar +1 more source
Enhancer transcripts mark active estrogen receptor binding sites
Genome Research, 2013 We have integrated and analyzed a large number of data sets from a variety of genomic assays using a novel computational pipeline to provide a global view of estrogen receptor 1 (ESR1; a.k.a. ERα) enhancers in MCF-7 human breast cancer cells.
N. Hah +4 more
semanticscholar +1 more source
Modeling, Simulating, and Parameter Fitting of Biochemical Kinetic Experiments [PDF]
arXiv, 2015 In many chemical and biological applications, systems of differential equations containing unknown parameters are used to explain empirical observations and experimental data. The DEs are typically nonlinear and difficult to analyze, requiring numerical methods to approximate the solutions.
arxiv
Journal of the National Cancer Institute, 2004 BACKGROUND Patients receiving adjuvant tamoxifen whose tumors express high levels of both HER2/neu (HER2) and the estrogen receptor (ER) coactivator AIB1 often develop tamoxifen resistance.
J. Shou +6 more
semanticscholar +1 more source
Analysis of differential splicing suggests different modes of short-term splicing regulation [PDF]
arXiv, 2016 Motivation: Alternative splicing is an important mechanism in which the regions of pre-mRNAs are differentially joined in order to form different transcript isoforms. Alternative splicing is involved in the regulation of normal physiological functions but also linked to the development of diseases such as cancer.
arxiv
FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection
Science Translational Medicine, 2013 Clomiphene and toremifene inhibit Ebola virus infection. Fertile Strategy for Ebola Infection Perhaps no virus has grasped the public’s imagination like Ebola virus.
L. Johansen +13 more
semanticscholar +1 more source
Estrogen receptors in the intact rat. [PDF]
, 1968 J.L. McGuire, Robert D. Lisk
openalex +1 more source
Neurobiology of Disease, 2013 The mechanism by which estrogen protects dopaminergic neurons has not yet been clarified. It is not known if changes in RhoA/Rho kinase activity are involved in the enhanced vulnerability of dopaminergic neurons observed after estrogen depletion.
Ana I. Rodriguez-Perez +4 more
doaj
Biology of Sex Differences, 2019 Background The obesity-related risk of developing metabolic syndrome is higher in males than in females of reproductive age, likely due to estrogen-mediated reduced adipose tissue inflammation and fibrosis with hypertrophied adipocytes.
Sujoy Ghosh +7 more
doaj +1 more source