Results 141 to 150 of about 282,884 (313)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Potential phytoestrogen alternatives exert cardio-protective mechanismsviaestrogen receptors

, 2017
Marthandam Asokan Shibu, Wei-Wen Kuo, Chia‐Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Li-Chin Chung, Chao‐Hung Lai, Lung-Fa Pan, V. Vijaya Padma, Chih‐Yang Huang   +9 more
openalex   +1 more source

Erratum to: Estrogen receptor β (ERβ) is a novel prognostic marker of recurrence survival in non-muscle-invasive bladder cancer potentially by inhibiting cadherin switch [PDF]

, 2015
Bangmin Han, Di Cui, Yifeng Jing, Yan Hong, Shujie Xia   +4 more
openalex   +1 more source

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, EarlyView.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Altered Estrogen Receptor Signaling Pathway in BRCA2-Deficient Estrogen Receptor-Positive/HER2-Negative Breast Cancer. [PDF]

Cancer Rep (Hoboken)
Kawasaki K, Masuyama M, Shimoda M, Seto I, Mishima C, Sota Y, Abe K, Masunaga N, Tsukabe M, Yoshinami T, Miyake T, Tanei T, Shimazu K.   +12 more
europepmc   +1 more source

Powerful dominant negative mutants of the human estrogen receptor

, 1993
B. Avery Ince, Yingping Zhuang, Carol K. Wrenn, David J. Shapiro, Benita S. Katzenellenbogen   +4 more
openalex   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Sex Differences in the Association of Simultaneous Decline in Blood Pressure and Decline in Cognition during Aging

Annals of Neurology, EarlyView.
Objective Both high and declining blood pressure (BP) are associated with risk of cognitive decline in older adults, and women have higher rates of hypertension and faster cognitive decline in late‐life. In old age, the relationship between changes in BP and changes in cognition is complex, and although sex differences in cognitive function and decline
Nicholas W. Baumgartner, Ana W. Capuano, Lisa L. Barnes, David A. Bennett, Zoe Arvanitakis   +4 more
wiley   +1 more source

Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha. [PDF]

MicroPubl Biol
Elzaghir R, Collins KC, Abdulshafi A, Ismail M, Asleh N, Saeed M, Galarza-Ramirez DE, Valladares E, Lewis A, Mena S, Pizzo A, Shyti A, Najor NA, Abdel Latif MK, Livezey MR.   +14 more
europepmc   +1 more source

Performance Standards for the Human Recombinant Estrogen Receptor Binding Assay [PDF]

, 2015
OECD
openalex   +1 more source