Results 361 to 370 of about 2,836,003 (403)

The histochemistry of estrogen receptors

Histochemistry, 1981
Estrogen receptors in frozen section of the rat uterus were demonstrated by a radiolabeled ligand binding technique. The bound hormone was extracted with ethanol and measured by liquid scintillation. The binding of 3H-estradiol-17 beta at various molar concentrations was inhibited by a 100-fold excess of DES, and the bound 3H-estradiol resisted ...
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Estrogen and estrogen receptors of breast cancer

Journal of Surgical Oncology, 1975
AbstractHuman breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen‐binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment.
Howard H. Sky-Peck, Velayudan Sahadevan, Steven G. Economou, Charles P. Perlia   +3 more
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An update on estrogen receptors

Seminars in Perinatology, 2000
The discovery of a second estrogen receptor (ER), ERbeta, has led to a complete change in our views on estrogen action. The previous dogmatic view that ERalpha represented the only estrogen receptor led to a static and simplistic concept of mechanisms of estrogen action with conceptual limitations in the development of novel estrogenic and ...
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American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

Archives of Pathology & Laboratory Medicine, 2010
PURPOSE To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers.
M. E. Hammond, Daniel F. Hayes, M. Dowsett, D. Allred, K. Hagerty, S. Badve, P. Fitzgibbons, G. Francis, Neil S. Goldstein, M. Hayes, David G. Hicks, S. Lester, R. Love, P. Mangu, L. McShane, K. Miller, C. K. Osborne, S. Paik, J. Perlmutter, A. Rhodes, H. Sasano, Jared N. Schwartz, F. C. Sweep, S. Taube, E. Torlakovic, P. Valenstein, G. Viale, D. Visscher, T. Wheeler, R. B. Williams, J. Wittliff, Antonio C. Wolff   +31 more
semanticscholar   +1 more source

A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors.

New England Journal of Medicine, 1989
We conducted a randomized, double-blind, placebo-controlled trial of postoperative therapy with tamoxifen (10 mg twice a day) in 2644 patients with breast cancer, histologically negative axillary nodes, and estrogen-receptor-positive (greater than or ...
B. Fisher, J. Costantino, C. Redmond, R. Poisson, D. Bowman, J. Couture, N. Dimitrov, N. Wolmark, D. Wickerham, Edwin R. Fisher, R. Margolese, A. Robidoux, H. Shibata, J. Terz, A. Paterson, M. Feldman, W. Farrar, James Evans, H. Lickley, Mary Ketner   +19 more
semanticscholar   +1 more source

Treatment of estrogen receptor-positive breast cancer.

Current Medicinal Chemistry, 2013
Estrogen receptor (ER) expression is the main indicator of potential responses to endocrine therapy (ET), and approximately 70% of human breast cancers (BCs) are hormone-dependent and ER-positive.
F. Lumachi, A. Brunello, M. Maruzzo, U. Basso, S. Basso   +4 more
semanticscholar   +1 more source

Estrogen Receptor Assay

JAMA: The Journal of the American Medical Association, 1977
To the Editor.— Kiang and Kennedy (238:59-60, 1977) have presented an interesting idea that may prove to be useful in the differential diagnosis of adenocarcinomas of unknown primary site. Unfortunately, however, the evidence offered hardly appears to justify their claim that positive estrogen receptor assays can indicate that metastases arose from ...
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Estrogen Receptors and Anti-Estrogen Therapies

2006
The realisation that breast cancer growth is regulated by the hormone estrogen led to the development of tamoxifen as the first target-directed cancer drug. Clearly, there is considerable headway to be made in further elucidating estrogen receptor function, in particular in identifying the mechanisms underlying endocrine resistance.
Simak Ali, Joanna Pike, Demetra Constantinidou, Lakjaya Buluwela   +3 more
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Estrogen receptor α is essential for induction of oxytocin receptor by estrogen

NeuroReport, 1998
The induction of oxytocin receptor (OTR) synthesis in the periphery and in the brain by estrogen is critical for reproductive success. Oxytocin receptors are involved in the control of parturition, milk ejection, and sexual and maternal behaviors.
Emilie F. Rissman, Zuoxin Wang, Ross Donaldson, Larry J. Young   +3 more
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ESTROGEN RECEPTORS IN RAT BONE: THEIR INTERACTION WITH ESTROGEN RECEPTOR MODULATORS

Endocrine Research, 2001
Estrogen receptors (ER) were studied in rat bone cytosol using immunoprecipitation, and Western blot technique. Ligand specificity of bone ER was studied using various known modulators of ER. Competitive experiments were performed under exchange conditions in bone tissue obtained from one day old rats.
Anil Kumar Dwivedi, R. Chaturvedi, S.R. Chowdhury, Rekha Pal, K. K. Kamboj   +4 more
openaire   +3 more sources