Results 51 to 60 of about 2,424,176 (193)
Joint Stream: Malignant Region Learning for Breast Cancer Diagnosis [PDF]
Volume 99, January 2025, 106899Early diagnosis of breast cancer (BC) significantly contributes to reducing the mortality rate worldwide. The detection of different factors and biomarkers such as Estrogen receptor (ER), Progesterone receptor (PR), Human epidermal growth factor receptor 2 (HER2) gene, Histological grade (HG), Auxiliary lymph node (ALN) status, and Molecular subtype ...
arxiv +1 more source
Journal of Medicinal Chemistry, 2015 Drugs that inhibit estrogen receptor alpha (ERα) or that block the production of estrogens remain frontline interventions in the treatment and management of breast cancer at all stages.
D. McDonnell, S. Wardell, J. Norris
semanticscholar +1 more source
Differential ligand binding affinities of human estrogen receptor-α isoforms.
PLoS ONE, 2013 Rapid non-genomic effects of 17β-estradiol are elicited by the activation of different estrogen receptor-α isoforms. Presence of surface binding sites for estrogen have been identified in cells transfected with full-length estrogen receptor-α66 (ER66 ...
Amanda H Y Lin +6 more
doaj +1 more source
Selective Estrogen Receptor Modulators [PDF]
Asian Spine Journal, 2016 Selective estrogen receptor modulators (SERMs) are now being used as a treatment for breast cancer, osteoporosis and postmenopausal symptoms, as these drugs have features that can act as an estrogen agonist and an antagonist, depending on the target ...
Ki-Chan An
doaj +1 more source
Healthcare in Low-resource Settings, 2023 Depot medroxyprogesterone acetate (DMPA) is a contraceptive method that prevents ovulation and reduces endometrial thickness. This study aimed to investigate the influence of Vigna unguiculata (VU) on estrogen receptor-α expression and endometrial ...
Rizki Fitrianingtyas +5 more
doaj +1 more source
Progesterone receptor modulates estrogen receptor-α action in breast cancer
Nature, 2015 Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα-induced gene target, but is also an ERα-associated protein that modulates its ...
Hisham Mohammed +23 more
semanticscholar +1 more source
Journal of Traditional and Complementary Medicine, 2018 The purpose of this study was to investigate the effect of genistein administration on the modulation of the estrogen receptor, inhibition of inflammation and angiogenesis in the murine model of peritoneal endometriosis.
Sutrisno Sutrisno +9 more
doaj
In Silico Evaluation of Alpha Mangostin and its Derivatives as a potential Anti-Cancer Agents [PDF]
BIO Web of ConferencesAlpha-Mangostin, a natural xanthone from Garcinia mangostana, and its structurally optimized derivatives were evaluated as anticancer agents targeting estrogen receptor proteins linked to breast cancer: Estrogen Receptor Alpha(3ERT), Estrogen Receptor ...
V Harini Rakshitha +3 more
doaj +1 more source
Differential effect of phosphorylation-defective survivin on radiation response in estrogen receptor-positive and -negative breast cancer. [PDF]
PLoS ONE, 2015 Survivin is a key member of the inhibitor of apoptosis protein family, and is considered a promising therapeutic target due to its universal overexpression in cancers.
Bisrat G Debeb +5 more
doaj +1 more source
Majalah Biomorfologi, 2021 Background: Globocan data in 2018 shows the cancer incidence in Indonesia. The highest case in women is breast cancer. The chance of survival for patients with high malignancy (Grade III) is only 11.86%, while for patients with low malignancy (Grade I ...
Windy Ayustyas Trisna +2 more
doaj +1 more source