Results 71 to 80 of about 2,801,225 (380)

Treatment of Girls and Boys with McCune-Albright Syndrome with Precocious Puberty - Update 2017 [PDF]

, 2017
The most common endocrinopathy associated with McCune-Albright Syndrome (MAS) is peripheral precocious puberty (PP) which occurs far more often in girls than in boys.
Eugster, Erica A., Neyman, Anna
core   +1 more source

Estrogen, Estrogen Receptor and Lung Cancer

International Journal of Molecular Sciences, 2017
Estrogen has been postulated as a contributor for lung cancer development and progression. We reviewed the current knowledge about the expression and prognostic implications of the estrogen receptors (ER) in lung cancer, the effect and signaling pathway ...
L. Hsu, N. Chu, S. Kao
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

FMO Interaction Energy between 17$β$-Estradiol, 17$α$-Estradiol and Human Estrogen Receptor $α$ [PDF]

arXiv, 2020
The estrogen receptor is a nuclear hormone receptor activated by the natural steroid hormone 17$\beta$-estradiol (E2). Fragment molecular orbital (FMO) calculations were performed which allowed us to obtain the interaction energy ($E_{int}$) between E2, 17$\alpha$-estradiol (17$\alpha$-E2) and the human estrogen receptor $\alpha$ ligand-binding domain.
arxiv  

Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.

New England Journal of Medicine, 1994
BACKGROUND AND METHODS Mutations in the estrogen-receptor gene have been thought to be lethal. A 28-year-old man whose estrogen resistance was caused by a disruptive mutation in the estrogen-receptor gene underwent studies of pituitary-gonadal function ...
Eric P. Smith, J. Boyd, G. Frank, Hiroyuki Takahashi, R. M. Cohen, B. Specker, T. Williams, D. Lubahn, K. Korach   +8 more
semanticscholar   +1 more source

Estrogen Binding Protein Activity in Morris Hepatoma 7777 Compared With Normal Rat Liver [PDF]

, 1984
Estrogen binding protein activities were determined in the cytosol from adult male Buffalo rat liver and Morris hepatoma 7777. Estrogen receptors were prepared using the protamine sulfate precipitation technique of Chamness.
Dileo, A, Eagon, PK, Francavilla, A, Ove, P, Sax, SA, Starz, TE, Van Thiel, DH, Wu, SK   +7 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation [PDF]

, 2016
Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-
Anagnostopoulou, Aikaterini, Dean, Afshan, Hood, Katie, Johansen, Anne Katrine Z., Loughlin, Lynn, MacLean, Margaret R., Morecroft, Ian, Nilsen, Margaret, Touyz, Rhian M., White, Kevin   +9 more
core   +1 more source

Bayesian Variable Selection for Probit Mixed Models Applied to Gene Selection [PDF]

Bayesian Analysis 6, 2 (2011) 209-230, 2011
In computational biology, gene expression datasets are characterized by very few individual samples compared to a large number of measurements per sample. Thus, it is appealing to merge these datasets in order to increase the number of observations and diversify the data, allowing a more reliable selection of genes relevant to the biological problem ...
arxiv   +1 more source