Results 41 to 50 of about 303,397 (337)

Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway

Scientific Reports, 2015
Formononetin is an isoflavone that has been shown to display estrogenic properties and induce angiogenesis activities. However, the interrelationship between the estrogenic properties and angiogenesis activities of formononetin are not well defined.
Shang Li, Yuanye Dang, Xuelin Zhou, Bin Huang, Xiaohui Huang, Zherui Zhang, Y. Kwan, S. Chan, G. Leung, S. M. Lee, M. Hoi   +10 more
semanticscholar   +1 more source

Alternative splicing of estrogen receptor alpha in hepatocellular carcinoma [PDF]

BMC Cancer, 2016
The role of estrogen receptor alpha (ERa), estrogen receptor beta (ERb) and ERa36 signaling in hepatocellular carcinoma (HCC) is not fully addressed.In this study, three cohorts were included: (i) primary HCC patients (N = 76, cohort P), (ii) colorectal liver metastasis (mCRC) (N = 32, cohort S), and (iii) HCC from The Cancer Genome Atlas (TCGA) (N ...
Jian Zhang, Jian Zhang, Jiamin Wei, Dongjie Yang, Yulong He, Jianwei Ren, Charing C N Chong, Paul B.S. Lai, George G. Chen   +8 more
openaire   +3 more sources

Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer

OncoTarget, 2015
The role of estrogen signaling in regulating prostate tumorigenesis is relatively underexplored. Although, an increasing body of evidence has linked estrogen receptor beta (ERβ) to prostate cancer, the function of estrogen receptor alpha (ERα) in ...
Sweta Mishra, Qin Tai, X. Gu, J. Schmitz, Ashley Poullard, R. Fajardo, D. Mahalingam, Xiaodong Chen, Xueqiong Zhu, Luzhe Sun   +9 more
semanticscholar   +1 more source

Estrogen-related receptor alpha: an orphan finds a family [PDF]

Breast Cancer Research, 2012
Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 ...
Aleksandra M. Ochnik, Douglas Yee
openaire   +4 more sources

aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.

PLoS ONE, 2014
In this study we describe the reproductive phenotypes of a novel mouse model in which Cre-mediated deletion of ERα is regulated by the aP2 (fatty acid binding protein 4) promoter.
Per Antonson, Marko Matic, Neil Portwood, Raoul V Kuiper, Galyna Bryzgalova, Hui Gao, Sara H Windahl, Patricia Humire, Claes Ohlsson, Per-Olof Berggren, Jan-Åke Gustafsson, Karin Dahlman-Wright   +11 more
doaj   +1 more source

Steroid-Functionalized Titanocenes: Docking Studies with Estrogen Receptor Alpha

Inorganics, 2016
Estrogen receptor alpha (ERα) is a transcription factor that is activated by hormones, with 17β-estradiol being its most active agonist endogenous ligand. ERα is also activated or inactivated by exogenous ligands. ER is overexpressed in hormone-dependent
Li Ming Gao, Wilson Maldonado, Xiomara Narváez-Pita, José A. Carmona-Negrón, Jesus Olivero-Verbel, Enrique Meléndez   +5 more
doaj   +1 more source

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Scientific Reports, 2014
The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor alpha (ERα) agonist and antagonist activity using two types of ER reporter gene cell lines, one ...
Ruili Huang, S. Sakamuru, Matt T. Martin, David M. Reif, R. Judson, K. Houck, W. Casey, J. Hsieh, K. Shockley, P. Ceger, J. Fostel, K. Witt, W. Tong, Daniel M. Rotroff, Tongan Zhao, P. Shinn, A. Simeonov, D. Dix, C. Austin, R. Kavlock, R. Tice, M. Xia   +21 more
semanticscholar   +1 more source

Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women [PDF]

Reproductive Biology and Endocrinology, 2006
Endometriosis is a disorder that affects 5% of the normal population but is present in up to 40% of women with pelvic pain and/or infertility. Recent evidence suggests that the endometrium of women with endometriosis exhibits progesterone insensitivity.
Ruth A. Lininger, K.B.C. Apparao, Steven L. Young, Wilder A. Palomino, Bruce A. Lessey   +4 more
openaire   +3 more sources

Estrogen Receptor Alpha Polymorphisms and the Risk of Malignancies

Pathology & Oncology Research, 2010
Estrogens represent risk factors for endocrine-related cancers and play also an important role in the development and progression of other malignancies. In order to analyze the associations between estrogen receptor gene alpha polymorphisms and cancers susceptibility, we genotyped six single nucleotide polymorphisms (SNPs) in 163 Caucasian cancer ...
L. Tamas, Emilian Damian Popovici, Andrei Anghel, Edward Seclaman, Diana Narita, Mariana Anghel   +5 more
openaire   +3 more sources

Estrogen Receptors Alpha and Beta in Acute Myeloid Leukemia [PDF]

Cancers, 2020
Estrogen receptor (ER) signaling has been widely studied in a variety of solid tumors, where the differential expression of ERα and ERβ subtypes can impact prognosis. ER signaling has only recently emerged as a target of interest in acute myeloid leukemia (AML), an aggressive hematological malignancy with sub-optimal therapeutic options and poor ...
Alessia Roma, Paul A. Spagnuolo
openaire   +2 more sources