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Antibody Validation for Estrogen Receptor Beta
2022Antibodies can cross-react with proteins other than their intended targets, and antibody-based applications can, if not properly validated, lead to flawed interpretations. When evaluating 13 anti-estrogen receptor beta (ERβ) antibodies in 2017, we concluded that only one of them was specific.
Madeleine, Birgersson +4 more
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Estrogen receptor beta and neural development
2021The female sex hormone estradiol (E2, 17β-estradiol) has important functions in the developing brain. In addition to regulating sexual differentiation of the brain, E2 participates in the development of brain areas involved in functions unrelated to reproduction, such as cognition.
Ivan, Nalvarte +3 more
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Role of Estrogen Receptor Beta in Estrogen Action
Annual Review of Physiology, 2001▪ Abstract There was a time when the classification of sex hormones was simple. Androgens were male and estrogens female. What remains true today is that in young adults androgen levels are higher in males and estrogen levels higher in females. More recently we have learned that estrogens are necessary in males for regulation of male sexual behavior ...
K, Pettersson, J A, Gustafsson
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Estrogen receptor β: the antimechanostat?
Bone, 2005We have known for sometime that sex hormones influence the growth, preservation, and loss of bone tissue in the skeleton. However, we are only beginning to recognize how estrogen influences the responsiveness of the skeleton to exercise. Frost's mechanostat theory proposes that estrogen reduces the mechanical strain required to initiate an osteogenic ...
L K, Saxon, C H, Turner
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2002
When the discovery of ERβ was reported in 1996 [1], many endocrinologists thought that, since this receptor had gone unnoticed for so long, it must be some sort of vestigial receptor with no function in the endocrinology of estrogen. This idea was quickly dispelled when ERβ-/- mice were created and found to have severely compromised ovarian function ...
Zhang Weihua +5 more
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When the discovery of ERβ was reported in 1996 [1], many endocrinologists thought that, since this receptor had gone unnoticed for so long, it must be some sort of vestigial receptor with no function in the endocrinology of estrogen. This idea was quickly dispelled when ERβ-/- mice were created and found to have severely compromised ovarian function ...
Zhang Weihua +5 more
openaire +1 more source
Photoperiod affects estrogen receptor alpha, estrogen receptor beta and aggressive behavior.
The European journal of neuroscience, 2007Estrogens have important effects on male and female social behavior. Despite growing knowledge of the anatomy and behavioral effects of the two predominant estrogen receptor subtypes in mammals (ERalpha and ERbeta), relatively little is known about how these receptors respond to salient environmental stimuli. Many seasonally breeding species respond to
Brian C, Trainor +2 more
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Human cell-based estrogen receptor beta dimerization assay
Chemico-Biological Interactions, 2023Estrogen is not only responsible for important functions in the human body, such as cell growth, reproduction, differentiation, and development, but it is also deeply related to pathological processes, such as cancer, metabolic and cardiovascular diseases, and neurodegeneration.
Hyeyeong Seo +6 more
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