Results 311 to 320 of about 154,423 (349)

Estrogen receptor β and breast cancer

European Journal of Surgical Oncology (EJSO), 2004
A second estrogen receptor, estrogen receptor-beta, was identified in 1996 and has led to an intensive re-evaluation of the role of estrogens in normal physiological and disease processes. While much has been learnt about this new receptor, there remain many outstanding questions, particularly regarding its prognostic significance and therapeutic ...
P J, Balfe, A H, McCann, H M, Welch, M J, Kerin   +3 more
openaire   +2 more sources

Estrogen receptor beta in breast cancer.

Endocrine-related cancer, 2002
Estrogen is essential for normal growth and differentiation in the mammary gland. It also supports growth of approximately 50% of primary breast cancers. For this reason, removal of estrogen or blocking of its action with the anti-estrogen, tamoxifen, is the main treatment for estrogen receptor alpha (ERalpha)-positive tumors. In 1996, when oncologists
C, Palmieri, G J, Cheng, S, Saji, M, Zelada-Hedman, A, Wärri, Z, Weihua, S, Van Noorden, T, Wahlstrom, R C, Coombes, M, Warner, J-A, Gustafsson   +10 more
openaire   +2 more sources

Challenging estrogen receptor β with phosphorylation

Trends in Endocrinology & Metabolism, 2010
From classical gland-based endocrinology to nuclear hormone receptor biology, tremendous progress has been made in our understanding of hormone responses underlying cellular communication. Estrogen elicits a myriad of biological processes in reproductive and peripheral target tissues through its interaction with the estrogen receptors ERalpha and ...
Mélanie, Sanchez, Nathalie, Picard, Karine, Sauvé, André, Tremblay   +3 more
openaire   +2 more sources

Metastases of prostate cancer express estrogen receptor-beta

Urology, 2004
To examine estrogen receptor-beta (ERbeta) expression in prostate cancer (CaP) metastases, thereby providing a basis for conducting estrogen therapy studies in patients with metastatic CaP. Advanced androgen-independent CaP is a serious health problem with no effective treatment at present.
Janice S, Lai, Lisha G, Brown, Lawrence D, True, Sarah J, Hawley, Ruth B, Etzioni, Celestia S, Higano, Shuk-Mei, Ho, Robert L, Vessella, Eva, Corey   +8 more
openaire   +2 more sources

Estrogen receptor modulators and estrogen receptor beta immunolabelling in human umbilical vein endothelial cells

Acta Histochemica, 2009
Human umbilical vein endothelial cells (HUVEC) exposed to the female sex hormone estradiol show different kinds of effects including increased elasticity, activation of plasma membrane Na+/H+ exchange, prostacyclin production, prevention of apoptosis and many others.
Bettina, Toth, Christoph, Scholz, Gitti, Saadat, Alrun, Geller, Sandra, Schulze, Ionannis, Mylonas, Klaus, Friese, Udo, Jeschke   +7 more
openaire   +2 more sources

Estrogen receptor alpha negative breast cancer patients: Estrogen receptor beta as a therapeutic target

The Journal of Steroid Biochemistry and Molecular Biology, 2008
Clinical management of breast cancer is increasingly guided by assessment of tumor phenotypic parameters. One of these is estrogen receptor (ER) status, currently defined by ERalpha expression. However with the discovery of a second ER, ERbeta and its variant isoforms, the definition of ER status is potentially more complex.
George P, Skliris, Etienne, Leygue, Peter H, Watson, Leigh C, Murphy   +3 more
openaire   +2 more sources

Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists

Bioorganic & Medicinal Chemistry Letters, 2006
Several tetrahydrofluorenones with a triazole fused across C7-C8 showed high levels of ERbeta-selectivity and were found to be potent ERbeta-agonists. As a class they demonstrate improved oral bioavailability in the rat over a parent class of 7-hydroxy-tetrahydrofluorenones.
Dann L, Parker, Dongfang, Meng, Ronald W, Ratcliffe, Robert R, Wilkening, Donald M, Sperbeck, Mark L, Greenlee, Lawrence F, Colwell, Sherrie, Lambert, Elizabeth T, Birzin, Katalin, Frisch, Susan P, Rohrer, Stefan, Nilsson, Ann-Gerd, Thorsell, Milton L, Hammond   +13 more
openaire   +2 more sources

Estrogen receptor beta expression in invasive breast cancer

Human Pathology, 2001
The aim of this work was to determine the extent of estrogen receptor beta (ER-beta) expression in invasive breast cancer (BrCA) and whether ER-beta expression is correlated with response to adjuvant hormonal therapy with tamoxifen (AHTT). Immunohistochemical staining (IHC) for estrogen receptor alpha (ER-alpha) and ER-beta was performed on sections of
S, Mann, R, Laucirica, N, Carlson, P S, Younes, N, Ali, A, Younes, Y, Li, M, Younes   +7 more
openaire   +2 more sources

Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium

Acta Histochemica, 2004
The endometrium expresses estrogen (ER) and progesterone receptors (PR), which are involved in autocrine and paracrine regulation processes in response to estrogen and progesterone. The aim of the present study was to evaluate immunohistochemical distribution patterns of estrogen receptor alpha (ER alpha), estrogen receptor beta (ER beta) and PR in ...
Ioannis, Mylonas, Udo, Jeschke, Naim, Shabani, Christina, Kuhn, Angelika, Balle, Silke, Kriegel, M S Markus S, Kupka, Klaus, Friese   +7 more
openaire   +2 more sources

Estrogen receptor β selective nonsteroidal estrogens: seeking clinical indications

Expert Opinion on Therapeutic Patents, 2010
Nonsteroidal estrogens have been known since the 1930s. However, the relatively recent (1996) discovery of estrogen receptor subtype beta (ERbeta) suggested a possible paradigm shift away from SERM-like selectivity. Selective ERbeta agonism would potentially allow expansion of estrogenic targeting into new indications (discussed herein) currently ...
Michael L, Mohler, Ramesh, Narayanan, Christopher C, Coss, Kejiang, Hu, Yali, He, Zhongzhi, Wu, Seoung-Soo, Hong, Dong Jin, Hwang, Duane D, Miller, James T, Dalton   +9 more
openaire   +2 more sources