Results 41 to 50 of about 71,407 (161)

Expression and regulation of estrogen receptor 2 and its coregulators in mouse granulosa cells

The Journal of Reproduction and Development, 2022
The cooperative effects of estrogen and oocyte-derived paracrine factors (ODPFs) play critical roles in the normal development of ovarian follicles; however, the mechanism underlying this cooperation has not been well studied.
Chihiro EMORI, Takuya KANKE, Haruka ITO, Yuki AKIMOTO, Wataru FUJII, Kunihiko NAITO, Koji SUGIURA   +6 more
doaj   +1 more source

Estrogen Receptor Beta Displays Cell Cycle-Dependent Expression and Regulates the G1 Phase through a Non-Genomic Mechanism in Prostate Carcinoma Cells

Cellular Oncology, 2008
Background: It is well known that estrogens regulate cell cycle progression, but the specific contributions and mechanisms of action of the estrogen receptor beta (ERβ) remain elusive.
Antoni Hurtado, Tomàs Pinós, Anna Barbosa-Desongles, Sandra López-Avilés, Jordi Barquinero, Jordi Petriz, Albert Santamaria-Martínez, Joan Morote, Inés de Torres, Joaquim Bellmunt, Jaume Reventós, Francina Munell   +11 more
doaj   +1 more source

Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site

Nature Communications, 2019
Taxanes are natural products which bind beta-tubulin, stabilize microtubules and have a broad spectrum of anticancer activity. Here authors employ a computational binding site similarity screen and cell-based assays to reveal a SERM cross-reactivity ...
Yu-Chen Lo, Olga Cormier, Tianyun Liu, Kendall W. Nettles, John A. Katzenellenbogen, Tim Stearns, Russ B. Altman   +6 more
doaj   +1 more source

DHEA metabolites activate estrogen receptors alpha and beta [PDF]

Steroids, 2013
Dehydroepiandrosterone (DHEA) levels were reported to associate with increased breast cancer risk in postmenopausal women, but some carcinogen-induced rat mammary tumor studies question this claim. The purpose of this study was to determine how DHEA and its metabolites affect estrogen receptors α or β (ERα or ERβ)-regulated gene transcription and cell ...
Kristy K Michael, Miller, Numan, Al-Rayyan, Margarita M, Ivanova, Kathleen A, Mattingly, Sharon L, Ripp, Carolyn M, Klinge, Russell A, Prough   +6 more
openaire   +2 more sources

Mouse Estrogen Receptor β Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor α [PDF]

Molecular Endocrinology, 1997
The recent discovery that an additional estrogen receptor subtype is present in various rat tissues has advanced our understanding of the mechanisms underlying estrogen signaling. Here we report on the cloning of the cDNA encoding the mouse homolog of estrogen receptor-beta (ER beta) and the functional characterization of mouse ER beta protein. ER beta
K, Pettersson, K, Grandien, G G, Kuiper, J A, Gustafsson   +3 more
openaire   +2 more sources

The Anti-Proliferative Effect of Genistein on Antioxidant System, Cell Proliferation, and Apoptosis: Implications for Hormone-Refractory Prostate Cancer Therapy

Ankara Üniversitesi Tıp Fakültesi Mecmuası
Objectives: This study aims to examine the effect of different genistein concentrations on apoptosis, estrogen receptor beta, and manganese superoxide dismutase (MnSOD) protein expressions in PC3 hormone-resistant metastatic prostate cancer cell lines ...
Nur Özten Kandaş
doaj   +1 more source

Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes

Drug Design, Development and Therapy, 2013
Sani Ismaila Muhammad,1,2 Ismail Maznah,1,3 Rozi Bint Mahmud,4 Mohammed Ibrahim Saeed,1 Mustapha Umar Imam,1 Aminu Ishaka11Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of ...
Muhammad SI, Maznah I, Mahmud RB, Saeed MI, Imam MU, Ishaka A   +5 more
doaj  

Comparison of FGF-8, FGF-10, FGF-Receptor 2, Androgen Receptor, Estrogen Receptor-A and SS in Healthy and Hypospadiac Children

Balkan Journal of Medical Genetics
In this study, we aimed to investigate the levels of Fibroblast Growth Factor-8 (FGF-8), FGF-10, FGF-Receptor-2 (FGFR-2), Androgen receptor (AR), Estrogen receptor alpha and beta (ER-α and ER-β) in the foreskins of children with and without hypospadias.
Emaratpardaz N, Turkyilmaz Z, Karabulut R, Dayanir D, Kaya C, Sert AAE, Arkan G, Ucaner FA, Kapisiz A, Eryilmaz S, Atan A, Sonmez K   +11 more
doaj   +1 more source

Sex differences in G protein-coupled estrogen receptor-mediated mechanisms in preclinical models of anxiety and fear

Frontiers in Behavioral Neuroscience
Sex differences are well-documented in the prevalence of psychiatric disorders, with anxiety and stress-related conditions more common in women.
AnBinh S. Tran, Lisa Y. Maeng, Lisa Y. Maeng   +2 more
doaj   +1 more source

Estrogen receptor beta--a new dimension in estrogen mechanism of action [PDF]

Journal of Endocrinology, 1999
The cloning of estrogen receptor (ER ) has provided the first example of a steroid hormone receptor existing as two isoforms, each of which is encoded by a separate gene (Kuiper et al. 1996). The finding of ER was met with great surprise, as the existence of more than one estrogen receptor had been actively denied for several decades. Attempts to clone
openaire   +2 more sources