Results 81 to 90 of about 150,800 (299)

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site

Nature Communications, 2019
Taxanes are natural products which bind beta-tubulin, stabilize microtubules and have a broad spectrum of anticancer activity. Here authors employ a computational binding site similarity screen and cell-based assays to reveal a SERM cross-reactivity ...
Yu-Chen Lo, Olga Cormier, Tianyun Liu, Kendall W. Nettles, John A. Katzenellenbogen, Tim Stearns, Russ B. Altman   +6 more
doaj   +1 more source

Involvement of miR-106b in tumorigenic actions of both prolactin and estradiol. [PDF]

, 2017
Prolactin promotes a variety of cancers by an array of different mechanisms. Here, we have investigated prolactin's inhibitory effect on expression of the cell cycle-regulating protein, p21.
Bustamante, Karissa, Chen, Kuan-Hui Ethan, Nguyen, Vi, Walker, Ameae M   +3 more
core   +1 more source

Estrogen receptor beta treats Alzheimer's disease.

Neural regeneration research, 2013
In vitro studies have shown that estrogen receptor β can attenuate the cytotoxic effect of amyloid β protein on PC12 cells through the Akt pathway without estrogen stimulation. In this study, we aimed to observe the effect of estrogen receptor β in Alzheimer's disease rat models established by intraventricular injection of amyloid β protein.
Tian, Zhu, Fan, Jia, Zhao, Yang, Bi, Sheng, Si, Lihui, Liu, Qun   +5 more
openaire   +2 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol [PDF]

, 2017
© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ
B Calippe, C Zhao, CJ Du, D Bakstad, D Farre, D Hartl, D Mullassery, D Xing, DA Turner, DG Spiller, E Kassi, E Munukka, ED Papadimitraki, FA Carvalho, I Caballero, JC Price, JC Price, JH Levine, K Dahlman-Wright, K Paech, KA Zarember, L Ashall, L Bjornstrom, M Junkin, M Lion, M Maggiolini, ME Quaedackers, MF Smith Jr., N Munoz, O Takeuchi, PL Zeitlin, R Galien, RC Dodel, RH Straub, S Ghisletti, S Rakoff-Nahoum, S Reardon, SK Drexler, TK Lee, WH Sun, Y Wang, Z Cai, ZX Shan   +42 more
core   +5 more sources

A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. [PDF]

, 2020
Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and
Aitchison, Katherine J, Binder, Elisabeth B, Carrillo-Roa, Tania, Cattaneo, Annamaria, DeModena, Anna, Henigsberg, Neven, Kelsoe, John R, Leckband, Susan G, Liu, Jia Jia, McCarthy, Michael, Mors, Ole, Ren, Hongyan, Rietschel, Marcella, Shekhtman, Tatyana, Wei, Ya Bin   +14 more
core   +2 more sources

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The Anti-Proliferative Effect of Genistein on Antioxidant System, Cell Proliferation, and Apoptosis: Implications for Hormone-Refractory Prostate Cancer Therapy

Ankara Üniversitesi Tıp Fakültesi Mecmuası
Objectives: This study aims to examine the effect of different genistein concentrations on apoptosis, estrogen receptor beta, and manganese superoxide dismutase (MnSOD) protein expressions in PC3 hormone-resistant metastatic prostate cancer cell lines ...
Nur Özten Kandaş
doaj   +1 more source