Results 91 to 100 of about 78,354 (303)

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands [PDF]

Journal of Endocrinology, 2004
Many studies have shown that the oral mucosa and salivary glands are sensitive to estrogen action. However, the expression of estrogen receptors (ERs) within these tissues is an area of controversy. ERs exist as two subtypes (ERalpha and ERbeta), and we hypothesized that the incongruity between ER expression and estrogen sensitivity may result from ...
H, Välimaa, S, Savolainen, T, Soukka, P, Silvoniemi, S, Mäkelä, H, Kujari, J-A, Gustafsson, M, Laine   +7 more
openaire   +2 more sources

Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells

, 1994
A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring ...
Wiegrebe, Wolfgang, Angerer, S. von, Angerer, E. von, Seidl, E., Mannschreck, A.   +4 more
core   +1 more source

TGF beta 1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways [PDF]

, 2010
Background: Decidualization (differentiation) of the endometrial stromal cells during the secretory phase of the menstrual cycle is essential for successful implantation.
Jones Marius, Philippa T K Saunders, Critchley, Hilary O. D., Kane, N.M., Hilary O D Critchley, Dey, Sudhansu Kumar, Kane Nicole M., Jan J Brosens, Marius Jones, Rodney W Kelly, Philippa T. K. Saunders, Jones, M., Kelly, Rodney W., Kane, Nicole M., Saunders Philippa T. K., Nicole M Kane, Jones, Marius, Brosens Jan J., Brosens, J.J., Kelly, R.W., Saunders, Philippa T. K., Jan J. Brosens, Hilary O. D. Critchley, Saunders, P.T.K., Brosens, Jan J., Saunders, Philippa T. K.; id_orcid, Critchley, H.O.D., Critchley Hilary O. D., Kelly Rodney W., Rodney W. Kelly, Nicole M. Kane   +30 more
core   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Estrogen Receptor Beta - RDKit Descriptors

, 2023
Dataset containing a Flame QSAR model for predicting Estrogen Receptor Beta activation. The model is described in the metadata.txt file. The er_beta_rdkit_v000001.tgz file can be imported into any instance of the open-source Flame (https://github.com/phi-
March Vila, Eric
core   +1 more source

Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes

Drug Design, Development and Therapy, 2013
Sani Ismaila Muhammad,1,2 Ismail Maznah,1,3 Rozi Bint Mahmud,4 Mohammed Ibrahim Saeed,1 Mustapha Umar Imam,1 Aminu Ishaka11Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia; 2Department of ...
Muhammad SI, Maznah I, Mahmud RB, Saeed MI, Imam MU, Ishaka A   +5 more
doaj  

Sex differences in G protein-coupled estrogen receptor-mediated mechanisms in preclinical models of anxiety and fear

Frontiers in Behavioral Neuroscience
Sex differences are well-documented in the prevalence of psychiatric disorders, with anxiety and stress-related conditions more common in women.
AnBinh S. Tran, Lisa Y. Maeng, Lisa Y. Maeng   +2 more
doaj   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors and amphioxus and human estrogen-related receptors: Towards a better understanding of estrogen receptor evolution

, 2008
*Background.* The origins of steroid-dependent regulation of the vertebrate estrogen receptor (ER) are poorly understood. Genes with statistically significant sequence similarity to vertebrate ERs have been found in lamprey, a basal vertebrate, and ...
Michael E. Baker, Charlie Chandsawangbhuwana   +1 more
core