Results 71 to 80 of about 150,800 (299)
Expression and regulation of estrogen receptor 2 and its coregulators in mouse granulosa cells
The Journal of Reproduction and Development, 2022 The cooperative effects of estrogen and oocyte-derived paracrine factors (ODPFs) play critical roles in the normal development of ovarian follicles; however, the mechanism underlying this cooperation has not been well studied.
Chihiro EMORI +6 more
doaj +1 more source
Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. [PDF]
, 2016 BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Bopassa, Jean C +12 more
core +1 more source
Mitochondrial localization of estrogen receptor β [PDF]
Proceedings of the National Academy of Sciences, 2004 Estrogen receptors (ERs) are believed to be ligand-activated transcription factors belonging to the nuclear receptor superfamily, which on ligand binding translocate into the nucleus and activate gene transcription. To date, two ERs have been identified: ERα and ERβ.
Shao-Hua, Yang +11 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti +27 more
wiley +1 more source
Cellular Oncology, 2008 Background: It is well known that estrogens regulate cell cycle progression, but the specific contributions and mechanisms of action of the estrogen receptor beta (ERβ) remain elusive.
Antoni Hurtado +11 more
doaj +1 more source
Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function [PDF]
, 2019 Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed.
Abedel-Majed, Mohamed A. +3 more
core +1 more source
Ageing And Cancer As Diseases Of Epigenesis [PDF]
, 2009 Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
core +2 more sources
The FASEB Journal, 2018 Upon menopause, women have an increased risk of cardiovascular disease, in part due to the decrease in estrogen production that occurs. While estrogen's cardioprotective effects have been known for many years, the exact mechanism of this protection is still under investigation.
Katherine Dvorak +3 more
openaire +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay [PDF]
, 2014 BACKGROUND: Congenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience in humans. METHODS: We tested for
Abreu, Fernanda V. +31 more
core +5 more sources