Results 301 to 310 of about 2,557,731 (353)

Estrogen receptors: how do they signal and what are their targets.

Physiological Reviews, 2007
During the past decade there has been a substantial advance in our understanding of estrogen signaling both from a clinical as well as a preclinical perspective.
N. Heldring, A. Pike, S. Andersson, J. Matthews, G. Cheng, J. Hartman, M. Tujague, A. Ström, E. Treuter, M. Warner, J. Gustafsson   +10 more
semanticscholar   +1 more source

The standardization of estrogen receptors

The Journal of Steroid Biochemistry and Molecular Biology, 1993
Tumour estrogen receptor (ER) status may determine the medical treatment of a patient with breast cancer; yet inter-laboratory results can vary markedly, particularly when absolute cut-offs in fmol/mg cytosol protein are used. The use of standardized log units is proposed to permit greater inter-laboratory comparability.
B.G. Mobbs, David R. McCready, Maureen E. Trudeau, Teik Chye Ooi, Carol Sawka, Eugene R. Tustanoff, Eamonn D. Ryan, H. Lavina A. Lickley, Wedad Hanna, Judy-Anne W. Chapman, Kathleen I. Pritchard, Donald J.A. Sutherland   +11 more
openaire   +3 more sources

The estrogen receptor family

Current Opinion in Obstetrics and Gynaecology, 1999
A significant flow of new data is currently being generated within the field of estrogen receptors and their mechanisms of action. This is primarily a result of the development of estrogen receptor knockout mice and the discovery of the second estrogen receptor, estrogen receptor beta.
Stefan Nilsson, Margaret Warner, Jan-Ake Gustafsson   +2 more
openaire   +3 more sources

Fulvestrant: an estrogen receptor antagonist that downregulates the estrogen receptor

Seminars in Oncology, 2003
Fulvestrant, a novel antiestrogen classified as an estrogen receptor antagonist without known agonist effects, was recently approved in the United States for the treatment of postmenopausal, hormone receptor-positive women with progressive metastatic breast cancer after antiestrogen therapy.
openaire   +3 more sources

Estrogen and estrogen receptors in thyroid carcinomas

Journal of Surgical Oncology, 1991
AbstractThyroid tissues, composed of normal thyroid (10 cases), Graves' thyroid (4), and papillary carcinoma (10), were measured for the presence of receptors for estrogen (ER) using an enzyme‐immunoassay method. The mean value of ER in papillary carcinoma tissues (4.0 ± 3.6 fmol/mg protein) was higher than that in normal thyroid tissues (0.8 ± 0.4 ...
Akitaka Nonomura, Yuji Mizukami, Masakuni Noguchi, Fujitsugu Matsubara, Takuma Hashimoto, Takatoshi Michigishi   +5 more
openaire   +3 more sources

The Role of Estrogen and Estrogen Receptors in Chemoresistance

Current Medicinal Chemistry, 2011
Drug resistance is one of the major obstacles limiting the success of cancer chemotherapy. Biological mechanisms contributing to drug resistance may be present de novo and related to inherent features or may be raised after exposure to anticancer drugs. In recent years, both clinical observations and experimental studies suggested that steroid hormones
H Zhang, Weimin Fan, Meihua Sui
openaire   +3 more sources

Biological Role of Estrogen and Estrogen Receptors

Critical Reviews in Biochemistry and Molecular Biology, 2002
(2002). Biological Role of Estrogen and Estrogen Receptors. Critical Reviews in Biochemistry and Molecular Biology: Vol. 37, No. 1, pp. 1-28.
Jan-Åke Gustafsson, Stefan Nilsson
openaire   +3 more sources

The histochemistry of estrogen receptors

Histochemistry, 1981
Estrogen receptors in frozen section of the rat uterus were demonstrated by a radiolabeled ligand binding technique. The bound hormone was extracted with ethanol and measured by liquid scintillation. The binding of 3H-estradiol-17 beta at various molar concentrations was inhibited by a 100-fold excess of DES, and the bound 3H-estradiol resisted ...
openaire   +3 more sources

Estrogen and estrogen receptors of breast cancer

Journal of Surgical Oncology, 1975
AbstractHuman breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen‐binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment.
Howard H. Sky-Peck, Velayudan Sahadevan, Steven G. Economou, Charles P. Perlia   +3 more
openaire   +3 more sources

An update on estrogen receptors

Seminars in Perinatology, 2000
The discovery of a second estrogen receptor (ER), ERbeta, has led to a complete change in our views on estrogen action. The previous dogmatic view that ERalpha represented the only estrogen receptor led to a static and simplistic concept of mechanisms of estrogen action with conceptual limitations in the development of novel estrogenic and ...
openaire   +3 more sources