Results 91 to 100 of about 2,936,436 (245)

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Growth of a Nipple Adenoma After Estrogen Replacement Therapy. [PDF]

Cureus, 2023
Skaribas EE, Tschen J.
europepmc   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Advances in the relationship between female intracranial aneurysmal subarachnoid hemorrhage and estrogen deficiency

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
The mortality and morbidity rate of subarachnoid hemorrhage is quite high. The incidence of intracranial aneurysmal subarachnoid hemorrhage in women, especially in postmenopausal women, is significantly higher than that in men, which is related to ...
Feng-xuan TIAN
doaj  

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Collaborative meta-analysis of prospective studies of plasma fibrinogen and cardiovascular disease [PDF]

, 2004
Background Many long-term studies have reported on associations of plasma fibrinogen concentration with cardiovascular disease, but few have been large enough to provide reliable estimates in different circumstances.
Willeit, J, Rasi, V., Danesh, J, Tunstall-Pedoe, H., Arocha-Pinango, CL, Chambless, L., Knottenbelt, C., Rodriguez-Larralde, A, Meade, TW, Fibrinogen Studies Collaboration, Folsom, AR, Evans, AE, Vahtera, E., Kannel, WB, Nyyssonen, K, Yano, K, Tosetto, A, Jousilahti, P., Feskens, E.J.M., Roa, E., De Stavola, B, Haverkate, F., Salomaa, V., Miller, GJ, Lowe, G.D.O., Yeh, JL, Loewel, H, Ford, I, Yano, K., Marchioli, R., Walker, M, Naito, Y, Rosenberg, RD, Wheeler, J, Koenig, W., Kitamura, A., Löwel, H., Schulte, H., Despres, J.P., Vahtera, E, de Maat, M.P.M., D'Agostino, R, Marchioli, R, Wilson, PWF, Benderly, M, Rudnicka, A., Lamarche, B., Lind, P., Norrie, J., Rosenberg, R.D., Dickinson, A, Mijares, M, Rosengren, A., Cantin, B., Bauer, KA, Smith, GD, König, W., Yarnell, J.W.G., Haverkate, F, Danesh, J., Yeh, J.L., Thompson, S.G., Smith, G., Salonen, JT, Nagy, E, Kostis, J.B., Eriksson, H, Collaboration, FS, Lappas, G, Smith, FB, Cremer, P, Salomaa, V, Brennan, P., Dickinson, A., Brunner, E., Kiechl, S., Salonen, J.T., Ducimetiere, P, Lowe, GDO, Rodriguez, B, Collins, R, Sweetnam, PM, Fernandez, V., Espinosa, R, Tuomainen, TP, Wilson, AC, Cantin, B, Palosuo, T, Palmieri, V, Palosuo, T., Goldbourt, U, Jousilahti, P, Nagy, E., Levy, D, Lee, AJ, Hense, HW, D'Agostino, R., Loewel, H., Rodeghiero, F, Hedblad, B, Evans, A.E., Collins, R., de Maat, MPM, Shipley, M., Cremer, P., Shepherd, J, Diez-Ewald, MP, Pekkanen, J, Sato, S., Wheeler, J., Folsom, A.R., Hense, H.W., Juhan-Vague, I., De Stavola, B., Meade, T.W., Kannel, W.B., Roa, E, Lamarche, B, Ducimetiere, P., Kromhout, D., Arveiler, D, Curb, J.D., Espinosa, R., Memon, A., Hense, H.-W., Iso, H., Rudnicka, A, Diez-Ewald, M.P., Assmann, G., Levy, D., Wilson, P.W.F., Cooper, J.A., Sweetnam, P.M., Shepherd, J., Torres, E, Arocha-Pinango, C.L., Valagussa, F., Wilson, A.C., Koenig, W, Ferrieres, J, Rodeghiero, F., Tunstall-Pedoe, H, Wu, K., Ford, I., Valagussa, F, Shipley, M, Arveiler, D., Cushman, M., Eriksson, H., Garrow, K, Campos, G, Tybjaerg-Hansen, A., Cushman, M, Naito, Y., Wu, K, Fowkes, FGR, Rodriguez, B., Cooper, JA, Elwood, PC, Chambless, L, Tuomainen, T.P., Cooper, J, Lewington, S, Rosengren, A, Hedblad, B., Tybjaerg-Hansen, A, Cooper, J., Nagel, D, Nyyssonen, K., Bauer, K.A., Campos, G., Lewington, S., Psaty, BM, Rasi, V, Sato, S, Mijares, M., Willeit, J., Walker, M., Ben-Shlomo, Y, Ryder, E, Despres, JP, Lee, A.J., Wilhelmsen, L., Miller, G.J., Pekkanen, J., Assmann, G, Kiechl, S, Memon, A, Brunner, E, Elwood, P.C., Lind, P, Psaty, B.M., Ryder, E., Ferrieres, J., Kostis, JB, Kromhout, D, Rodriguez-Larralde, A., Yarnell, JWG, Dagenais, GR, Schulte, H, Feskens, EJM, Fowkes, F.G.R., Juhan-Vague, I, Wilhelmsen, L, Tosetto, A., Brennan, P, Torres, E., Nagel, D., Knottenbelt, C, Iso, H, Curb, JD, Amouyel, P., Kitamura, A, Goldbourt, U., Fernandez, V, Thompson, S., Lappas, G., Smith, F.B., Palmieri, V., Dagenais, G.R., Amouyel, P, Ben Shlomo, Y., Thompson, SG, Norrie, J, Thompson, S, Garrow, K., Benderly, M.   +226 more
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Thrombosis prevention trial: compliance with warfarin treatment and investigation of a retained effect. [PDF]

, 2003
BACKGROUND: The Thrombosis Prevention Trial was a primary prevention factorial trial that reported a reduction in the risk of coronary heart disease (CHD) with warfarin and/or aspirin.
Ashby, Deborah, Rudnicka, Alicja R, Meade, Tom, Brennan, Patrick   +3 more
core   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

ENDOMETRIUM AND HORMONAL REPLACEMENT THERAPY

Zdravniški Vestnik, 2008
BACKGROUND Estrogen induces endometrial stimulation and increases the risk for endometrial hyperplasia and endometrial cancer. Added progestin diminishes endometrial stimulation.The risk for endometrial hyperplasia with hormonal replacement therapy (HRT)
Branka Žegura
doaj