Results 91 to 100 of about 50,421 (294)

Successful Pregnancies Following Hormone Replacement Therapy in a Patient with Premature Ovarian Failure: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2013
Premature ovarian failure is a serious life-changing condition that affects young women, remains an enigma and the researcher’s challenge. Spontaneous pregnancy in a patient with POF is uncommon.
SUNIL KUMAR K.S., LAXMI V. YALIWAL, RATHNAMALA M. DESAI   +2 more
doaj  

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Ryzyko choroby zatorowo-zakrzepowej związane z terapią hormonalną okresu okołomenopauzalnego

Menopause Review, 2011
Decision on implementing hormone therapy in perimenopausal woman has to be based on analysis of potentialrisks and benefits of such treatment. Although rarely observed, one of the most serious complication ofhormonal therapy is thromboembolic disease ...
Wojciech Kwaśniewski, Bartłomiej Barczyński, Jan Kotarski   +2 more
doaj  

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

The Impact of Sex Hormones on Transcranial Magnetic Stimulation Against the Oxidative Stress in the Pathogenesis of Multiple Sclerosis

Biomolecules
Background: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease with a higher prevalence in women. While puberty appears to act as a trigger for MS, menopause has no clear effects on disease progression.
Begoña M. Escribano, Manuel E. Valdevira, Ana Muñoz-Jurado, Montse Feijóo, Eduardo Agüera, Javier Caballero-Villarraso, Manuel LaTorre, Ana I. Giraldo, Abel Santamaría, Isaac Túnez   +9 more
doaj   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Genetic determinants of the response to bezafibrate treatment in the lower extremity arterial disease event reduction (LEADER) trial. [PDF]

, 2002
Genetic determinants of baseline levels and the fall in plasma triglyceride and fibrinogen levels in response to bezafibrate treatment were examined in 853 men taking part in the lower extremity arterial disease event reduction (LEADER) trial.
Meade, TW, Jamshidi, Y, Flavell, DM, Hawe, E, Humphries, SE, MacCallum, PK   +5 more
core   +1 more source

Sex‐Based Body Composition Changes in Patients With Rectal Cancer Undergoing Preoperative Chemoradiotherapy: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
This prospective study observed that preoperative chemoradiotherapy for rectal cancer was associated with reductions in body fat and grip strength, which appeared to be more pronounced in female patients. These findings suggest that sex‐sensitive nutritional and exercise support may be beneficial to help maintain muscle mass and physical function ...
Shinya Abe, Hiroaki Nozawa, Kentaro Abe, Yumi Yokota, Shunsuke Hori, Yusuke Taguchi, Mitsutaka Yakabe, Kazuhito Sasaki, Sumito Ogawa, Soichiro Ishihara   +9 more
wiley   +1 more source

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. [PDF]

, 2012
BACKGROUND: Daily aspirin reduces the long-term incidence of some adenocarcinomas, but effects on mortality due to some cancers appear after only a few years, suggesting that it might also reduce growth or metastasis.
Belch, Jill FF, Belch, JFF, Rothwell, Peter M., Belch, JF, Mehta, Ziyah, Rothwell, PM, Price, Jacqueline F., Wilson, M, Rothwell, Peter M, Belch, Jill F. F.; id_orcid, Price, Jacqueline F, Meade, TW, Price, JF, Meade, Tom W., Wilson, Michelle, Meade, Tom W, Rothwell, Peter, Mehta, Z   +17 more
core   +1 more source

Growth of a Nipple Adenoma After Estrogen Replacement Therapy. [PDF]

Cureus, 2023
Skaribas EE, Tschen J.
europepmc   +1 more source