Results 81 to 90 of about 50,235 (294)

Thrombotic variables and risk of idiopathic venous thromboembolism in women aged 45-64 years - Relationships to hormone replacement therapy [PDF]

, 2000
Hormone replacement therapy (HRT) has been shown to increase the relative risk of idiopathic venous thromboembolism (VTE) about threefold in several observational studies and one randomised controlled trial. Whether or not this relative risk is higher in
Rumley, A., Daly, E., Gough, P., Woodward, M., Lowe, G., Vessey, M.   +5 more
core  

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Do Estrogens improve bone mass in osteoporotic women over ten years of menopause

São Paulo Medical Journal
A retrospective analysis of 24 patients with established osteoporosis and with ten or more years of menopause treated with conjugated estrogen, progesterone and calcium followed for one year has been performed.
Vera Lucia Szejnfeld, Jorge Saad Souen, Edmund Chada Baracat, Edgard Atra, Geraldo Rodrigues de Lima   +4 more
doaj   +1 more source

Oestrogen replacement therapy may improve memory functioning in the absence of APOE e4

, 2004
There is currently intense controversy regarding the use of hormone replacement therapy (HRT) in postmenopausal women, in relation to its therapeutic efficacy in Alzheimer's disease (AD).
Stuckey, B.G.A., Laws, S.M., Nolan, D., Hewson-Bower, B., Baker, L.D., Foster, J.K., Clarnette, R., Burkhardt, M.S., Martins, R.N., Gandy, S.E., Craft, S.   +10 more
core  

Thrombosis prevention trial: compliance with warfarin treatment and investigation of a retained effect. [PDF]

, 2003
BACKGROUND: The Thrombosis Prevention Trial was a primary prevention factorial trial that reported a reduction in the risk of coronary heart disease (CHD) with warfarin and/or aspirin.
Ashby, Deborah, Rudnicka, Alicja R, Meade, Tom, Brennan, Patrick   +3 more
core   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Ryzyko choroby zatorowo-zakrzepowej związane z terapią hormonalną okresu okołomenopauzalnego

Menopause Review, 2011
Decision on implementing hormone therapy in perimenopausal woman has to be based on analysis of potentialrisks and benefits of such treatment. Although rarely observed, one of the most serious complication ofhormonal therapy is thromboembolic disease ...
Wojciech Kwaśniewski, Bartłomiej Barczyński, Jan Kotarski   +2 more
doaj  

Successful Pregnancies Following Hormone Replacement Therapy in a Patient with Premature Ovarian Failure: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2013
Premature ovarian failure is a serious life-changing condition that affects young women, remains an enigma and the researcher’s challenge. Spontaneous pregnancy in a patient with POF is uncommon.
SUNIL KUMAR K.S., LAXMI V. YALIWAL, RATHNAMALA M. DESAI   +2 more
doaj  

Sex‐Based Body Composition Changes in Patients With Rectal Cancer Undergoing Preoperative Chemoradiotherapy: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
This prospective study observed that preoperative chemoradiotherapy for rectal cancer was associated with reductions in body fat and grip strength, which appeared to be more pronounced in female patients. These findings suggest that sex‐sensitive nutritional and exercise support may be beneficial to help maintain muscle mass and physical function ...
Shinya Abe, Hiroaki Nozawa, Kentaro Abe, Yumi Yokota, Shunsuke Hori, Yusuke Taguchi, Mitsutaka Yakabe, Kazuhito Sasaki, Sumito Ogawa, Soichiro Ishihara   +9 more
wiley   +1 more source