Protection of HT22 neuronal cells against chemically-induced ferroptosis by catechol estrogens: protein disulfide isomerase as a mechanistic target [PDF]
Scientific ReportsFerroptosis is a form of regulated cell death, characterized by excessive iron-dependent lipid peroxidation. Biochemically, ferroptosis can be selectively induced by erastin through glutathione depletion or through inhibition of glutathione peroxidase 4 ...
Xuanqi Huang, Ming-Jie Hou, Bao Ting Zhu
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Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers [PDF]
Frontiers in Genetics, 2014 Infection with helminth parasites remains a persistent public health problem in developing countries. Three of these pathogens, the liver flukes Clonorchis sinensis, Opisthorchis viverrini and the blood fluke Schistosoma haematobium, are of particular ...
José M Correia da Costa +13 more
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Scientific Reports, 2023 Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer (BC) cells.
Lucia Janacova +8 more
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Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium. [PDF]
PLoS ONE, 2014 BackgroundSchistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature.
Júlio Santos +16 more
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Oral contraceptives containing ethinyl estradiol and drospirenone increase hydroxylation and methylation of endogenous estrogen but not genotoxic estrogen DNA-adduct formation [PDF]
Scientific ReportsCombined oral contraceptives (COCs) are commonly prescribed for the prevention of pregnancy, as well as numerous other non-contraceptive health reasons.
Gerda Venter +4 more
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Genome-wide mapping and quantification of DNA damage induced by catechol estrogens using Click-Probe-Seq and LC-MS2 [PDF]
Communications BiologyGenotoxic estrogen metabolites generate various DNA lesions; however, their target genes and carcinogenic mechanisms remain unexplored. Here, genome-wide sequencing using click probe enrichment coupled with liquid chromatography-tandem mass spectrometry (
Quynh-Trang Do +5 more
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Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers [PDF]
Cell Communication and SignalingBackground Endometrial cancer is the most common gynecologic malignancy found in developed countries. Because therapy can be curative at first, early detection and diagnosis are crucial for successful treatment.
Katarzyna Bukato +4 more
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Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. [PDF]
PLoS ONE, 2011 There is association between exposure to estrogens and the development and progression of hormone-dependent gynecological cancers. Chemical carcinogenesis by catechol estrogens derived from oxidative metabolism is thought to contribute to breast cancer ...
Irida Kastrati +7 more
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Molecules, 2021 Nordihydroguaiaretic acid (NDGA) is a major lignan metabolite found in Larrea spp., which are widely used in South America to treat various diseases. In breast tissue, estradiol is metabolized to the catechol estrogens such as 4-hydroxyestradiol (4-OHE2),
Jin-Hee Kim +5 more
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Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications
Journal of Pharmaceutical Analysis, 2021 Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that ...
Fang-Yuan Wang +7 more
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