Results 141 to 150 of about 4,921 (204)
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Journal of Steroid Biochemistry, 1981
Abstract Catechol estrogens (CEs) are a major group of active natural estrogen metabolites, formed by aromatic hydroxylation of primary estrogens at either the C-2 or C-4 position. These compounds may participate in the mechanism of estrogen action on the brain and pituitary gland.
N J, MacLusky +3 more
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Abstract Catechol estrogens (CEs) are a major group of active natural estrogen metabolites, formed by aromatic hydroxylation of primary estrogens at either the C-2 or C-4 position. These compounds may participate in the mechanism of estrogen action on the brain and pituitary gland.
N J, MacLusky +3 more
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Journal of Steroid Biochemistry, 1988
Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-
Y J, Abul-Hajj, P L, Cisek
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Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-
Y J, Abul-Hajj, P L, Cisek
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Catechol estrogen methylene ethers
Steroids, 1974Abstract We have prepared 2-hydroxyestrone 2,3-methylene ether and 2-hydroxy-estradiol 2,3-methylene ether; these compounds were not found as urinary metabolites of radioactive estrone, estradiol or 2-methoxyestrone in humans.
A M, Femino +3 more
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NMR spectra of estrogen catechols
Tetrahedron, 1968Abstract The NMR of various estrogen catechol derivatives were observed in CDCl 3 and DMSO. The chemical shifts of the aromatic protons permit the ready assignment of structure to isomeric monoderivatives. The reasons for the different chemical shifts of the two aromatic protons in 2-hydroxyestrogens are discussed.
J, Fishman, J S, Liang
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Adduction of catechol estrogens to nucleosides
Steroids, 2002We report the formation, detection, quantitation and structural characterization of products resulting from the adduction of deoxynucleosides (deoxyadenosine, deoxyguanosine, deoxycytidine and 5-methyldeoxycytidine) to the catechol estrogens (CE) of estrone, estradiol-17beta and estradiol-17 alpha. The crude products are obtained in a one-pot synthesis
Jouanin, Isabelle +4 more
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Obstetrical & Gynecological Survey, 1977
Catechol estrogens have been identified and measured in rat brain and various endocrine tissues with the use of a sensitive radioenzymatic assay. The specificity of this assay was confirmed by thin-layer chromatography and mass spectral analysis of the reaction products.
S M, Paul, J, Axelrod
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Catechol estrogens have been identified and measured in rat brain and various endocrine tissues with the use of a sensitive radioenzymatic assay. The specificity of this assay was confirmed by thin-layer chromatography and mass spectral analysis of the reaction products.
S M, Paul, J, Axelrod
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Catechol estrogens as inhibitors of leukotriene synthesis
Biochemical Pharmacology, 1998Estrogens have a beneficial effect on atherosclerosis and osteoporosis after menopause, but their exact mechanism of action is still unknown. The aim of the present study was to investigate the effects of estradiol and its metabolites catechol estrogens on arachidonic acid metabolism in vitro.
J, Alanko +5 more
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METABOLISM OF CATECHOL ESTROGEN BY HUMAN ERYTHROCYTES
The Journal of Clinical Endocrinology & Metabolism, 1977In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone in vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone
G W, Bates +3 more
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In vitro metabolic conjugation of catechol estrogens
Journal of Steroid Biochemistry, 1984In vitro metabolic conjugation of the catechol estrogens, 2-hydroxyestrone and 4-hydroxyestrone, has been investigated by means of HPLC with electrochemical detection. Sulfation of 2-hydroxyestrone and 4-hydroxyestrone with the rat liver 105 000 g supernatant fortified with 3'-phosphoadenosine-5'-phosphosulfate provided the 2- and 4-monosulfates ...
K, Shimada +3 more
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Inhibition of dihydropteridine reductase by catechol estrogens
Journal of Neuroscience Research, 1983AbstractCatechol estrogens, such as 2‐hydroxyestriol, 2‐hydroxyestradiol, and 2‐hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 × 10−6M. Catechol estrogens lose approximately half of their inhibitory potency if the C‐2 hydroxyl groups are methylated.
R S, Shen, C W, Abell
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