Results 151 to 160 of about 4,921 (204)
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Catechol estrogen formation in mouse uterus
Journal of Steroid Biochemistry, 1988Estrogen 2/4-hydroxylase (ESH) and catechol-O-methyltransferase (COMT) activities in mouse liver and uterus were studied. While 2-hydroxyestradiol (2-OHE2) was the predominant product in the liver, equal amounts of 2- and 4-hydroxyestradiol were produced in the uterus.
C, Bunyagidj, J A, McLachlan
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Steroids, 1983
The mechanisms underlying the differences in uterotrophic potency between 2- and 4-hydroxyestrogens were explored. Doses of estradiol (E2)(10 micrograms/kg), 2-OHE2 (500 micrograms/kg) and 4-OHE2 (100 micrograms/kg) sufficient to induce near maximal cell nuclear estrogen receptor (ERn) binding were injected subcutaneously into 26 day old female rats ...
E R, Barnea, N J, MacLusky, F, Naftolin
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The mechanisms underlying the differences in uterotrophic potency between 2- and 4-hydroxyestrogens were explored. Doses of estradiol (E2)(10 micrograms/kg), 2-OHE2 (500 micrograms/kg) and 4-OHE2 (100 micrograms/kg) sufficient to induce near maximal cell nuclear estrogen receptor (ERn) binding were injected subcutaneously into 26 day old female rats ...
E R, Barnea, N J, MacLusky, F, Naftolin
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Carcinogenicity of catechol estrogens in Syrian hamsters
Journal of Steroid Biochemistry, 1986Estradiol and other estrogens induce renal carcinoma in male Syrian hamsters. The mechanism of carcinogenesis still remains unclear. Activation of estrogens to catechol metabolites has in the past been postulated to play a role in estrogen-induced carcinogenesis. Therefore, the carcinogenic activity of catechol estrogens was investigated.
J G, Liehr +3 more
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Mechanism of catechol estrogen formation in man
Steroids, 1973Abstract Following the administration of estrone- 3 H-sulfate- 35 S to man, estrone sulfate, 2-methoxyestrone sulfate and 2-hydroxyestrone-2-sulfate were isolated from urine and purified. Their isotope content showed that estrone sulfate and 2-methoxyestrone sulfate retained 23 and 21% of the originally present 35 S, while 2-hydroxyestrone estrone ...
J, Fishman, I, Yoshizawa, L, Hellman
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Metabolism of Catechol Estrogen Ethers in Man
The Journal of Clinical Endocrinology & Metabolism, 1970ABSTRACT The isomeric [14CH3] monomethyl ethers as well as the dimethyl ether of 2-hydroxyestrone-6,7-3H were prepared. Each double-labeled substrate was administered to man and its excretion and metabolism was followed. Conjugation was predominantly with some other substance than glucuronic acid and neither of the 2- or 3-monomethyl ethers was O ...
I, Yoshizawa, J, Fishman
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A radioimmunoassay method for urinary catechol estrogens
Steroids, 1978A radioimmunoassay method for urinary catechol estrogens is described; The specific nature of the antisera allows direct analyses of acid hydrolyzed urine. A LH-20 Sephadex column chromatography can be employed for individual determinations of 2-hydroxyestrone and 2-hydroxyestradiol.
S C, Chattoraj +3 more
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Activity of mushroom tyrosinase on catechol and on a catechol estrogen in an organic solvent
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993A suspension of tyrosinase-coated glass beads in butanol effectively oxidizes catechol substrate. The enzyme is not soluble in the organic solvent and activity can be stopped by removal of the solid state enzyme after low-speed centrifugation or decantation.
G M, Jacobsohn +2 more
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Regioselective reaction of thiols with catechol estrogens and estrogen-O-quinones
Journal of Steroid Biochemistry, 1986Incubations of [3H]estradiol and [3H]2-hydroxyestradiol (2-OHE2) with rat liver microsomes and mushroom tyrosinase were carried out in the presence of glutathione and 2-mercaptoethanol. A ratio of about 3.5:1 for the C-4 and C-1 thioether conjugates of 2-OHE2 was observed.
Y J, Abul-Hajj, P L, Cisek
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Active nonaromatic intermediates in the conversion of steroidal estrogens into catechol estrogens
Biochemistry, 1986A mechanism is proposed for mixed-function oxidase-catalyzed formation of the catechol estrogens 2-hydroxy- and 4-hydroxyestradiol from estradiol. This mechanism involves nonaromatic epoxyenones as intermediates. The isomeric 1 alpha,2 alpha-epoxy-17 beta-hydroxyestr-4-en-3-one and 1 beta,2 beta-epoxy-17 beta-hydroxyestr-4-en-3-one (the latter as its ...
P W, Le Quesne +3 more
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Steroids, 1980
Five catechol estrogens and two 2-methoxyestrogens were compared for their relative affinity of binding to hypothalamic, pituitary, and uterine cytosol estrogen receptors; and for the kinetics of the catechols' methylation by hepatic catechol-0-methyltransferase.
G R, Merriam +3 more
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Five catechol estrogens and two 2-methoxyestrogens were compared for their relative affinity of binding to hypothalamic, pituitary, and uterine cytosol estrogen receptors; and for the kinetics of the catechols' methylation by hepatic catechol-0-methyltransferase.
G R, Merriam +3 more
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