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Estrogen genotoxicity causes preferential development of Fuchs endothelial corneal dystrophy in females. [PDF]
Redox BiolKumar V +13 more
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Journal of Steroid Biochemistry, 1981
Abstract Catechol estrogens (CEs) are a major group of active natural estrogen metabolites, formed by aromatic hydroxylation of primary estrogens at either the C-2 or C-4 position. These compounds may participate in the mechanism of estrogen action on the brain and pituitary gland.
N J, MacLusky +3 more
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Abstract Catechol estrogens (CEs) are a major group of active natural estrogen metabolites, formed by aromatic hydroxylation of primary estrogens at either the C-2 or C-4 position. These compounds may participate in the mechanism of estrogen action on the brain and pituitary gland.
N J, MacLusky +3 more
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Obstetrical & Gynecological Survey, 1977
Catechol estrogens have been identified and measured in rat brain and various endocrine tissues with the use of a sensitive radioenzymatic assay. The specificity of this assay was confirmed by thin-layer chromatography and mass spectral analysis of the reaction products.
S M, Paul, J, Axelrod
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Catechol estrogens have been identified and measured in rat brain and various endocrine tissues with the use of a sensitive radioenzymatic assay. The specificity of this assay was confirmed by thin-layer chromatography and mass spectral analysis of the reaction products.
S M, Paul, J, Axelrod
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Carcinogenicity of catechol estrogens in Syrian hamsters
Journal of Steroid Biochemistry, 1986Estradiol and other estrogens induce renal carcinoma in male Syrian hamsters. The mechanism of carcinogenesis still remains unclear. Activation of estrogens to catechol metabolites has in the past been postulated to play a role in estrogen-induced carcinogenesis. Therefore, the carcinogenic activity of catechol estrogens was investigated.
J G, Liehr +3 more
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Toxicology and Applied Pharmacology, 2000
The catechol metabolites of estradiol, 2- and 4-hydroxyestradiol (2-OHE(2) and 4-OHE(2), respectively) are potent signaling molecules and are hypothesized to be central to estrogen-linked carcinogenesis. Methylation by catechol-O-methyltransferase (COMT) is the principal means of catechol estrogen (CE) deactivation in the liver and other tissues.
C E, Garner +3 more
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The catechol metabolites of estradiol, 2- and 4-hydroxyestradiol (2-OHE(2) and 4-OHE(2), respectively) are potent signaling molecules and are hypothesized to be central to estrogen-linked carcinogenesis. Methylation by catechol-O-methyltransferase (COMT) is the principal means of catechol estrogen (CE) deactivation in the liver and other tissues.
C E, Garner +3 more
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A radioimmunoassay method for urinary catechol estrogens
Steroids, 1978A radioimmunoassay method for urinary catechol estrogens is described; The specific nature of the antisera allows direct analyses of acid hydrolyzed urine. A LH-20 Sephadex column chromatography can be employed for individual determinations of 2-hydroxyestrone and 2-hydroxyestradiol.
S C, Chattoraj +3 more
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Journal of Steroid Biochemistry, 1988
Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-
Y J, Abul-Hajj, P L, Cisek
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Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-
Y J, Abul-Hajj, P L, Cisek
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Catechol estrogen methylene ethers
Steroids, 1974Abstract We have prepared 2-hydroxyestrone 2,3-methylene ether and 2-hydroxy-estradiol 2,3-methylene ether; these compounds were not found as urinary metabolites of radioactive estrone, estradiol or 2-methoxyestrone in humans.
A M, Femino +3 more
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NMR spectra of estrogen catechols
Tetrahedron, 1968Abstract The NMR of various estrogen catechol derivatives were observed in CDCl 3 and DMSO. The chemical shifts of the aromatic protons permit the ready assignment of structure to isomeric monoderivatives. The reasons for the different chemical shifts of the two aromatic protons in 2-hydroxyestrogens are discussed.
J, Fishman, J S, Liang
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Catechol estrogen formation in mouse uterus
Journal of Steroid Biochemistry, 1988Estrogen 2/4-hydroxylase (ESH) and catechol-O-methyltransferase (COMT) activities in mouse liver and uterus were studied. While 2-hydroxyestradiol (2-OHE2) was the predominant product in the liver, equal amounts of 2- and 4-hydroxyestradiol were produced in the uterus.
C, Bunyagidj, J A, McLachlan
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