Results 171 to 180 of about 319,930 (224)
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Adduction of catechol estrogens to nucleosides
Steroids, 2002We report the formation, detection, quantitation and structural characterization of products resulting from the adduction of deoxynucleosides (deoxyadenosine, deoxyguanosine, deoxycytidine and 5-methyldeoxycytidine) to the catechol estrogens (CE) of estrone, estradiol-17beta and estradiol-17 alpha. The crude products are obtained in a one-pot synthesis
Jouanin, Isabelle +4 more
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Steroids, 1983
The mechanisms underlying the differences in uterotrophic potency between 2- and 4-hydroxyestrogens were explored. Doses of estradiol (E2)(10 micrograms/kg), 2-OHE2 (500 micrograms/kg) and 4-OHE2 (100 micrograms/kg) sufficient to induce near maximal cell nuclear estrogen receptor (ERn) binding were injected subcutaneously into 26 day old female rats ...
E R, Barnea, N J, MacLusky, F, Naftolin
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The mechanisms underlying the differences in uterotrophic potency between 2- and 4-hydroxyestrogens were explored. Doses of estradiol (E2)(10 micrograms/kg), 2-OHE2 (500 micrograms/kg) and 4-OHE2 (100 micrograms/kg) sufficient to induce near maximal cell nuclear estrogen receptor (ERn) binding were injected subcutaneously into 26 day old female rats ...
E R, Barnea, N J, MacLusky, F, Naftolin
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Gas chromatography — mass spectrometry of catechol estrogens
Steroids, 1974Abstract The gas chromatographic and mass spectrometric properties of 19 catechol estrogens and catechol estrogen methyl ethers are reported. The gas chromatographic behaviour of the TMS-derivatives on the stationary phases OV-1, OV-3, OV-7, and OV-17 is examined and correlated with their molecular weight, shape, and polarity. The characteristic mass
H O, Hoppen, L, Siekmann
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Catechol estrogens as inhibitors of leukotriene synthesis
Biochemical Pharmacology, 1998Estrogens have a beneficial effect on atherosclerosis and osteoporosis after menopause, but their exact mechanism of action is still unknown. The aim of the present study was to investigate the effects of estradiol and its metabolites catechol estrogens on arachidonic acid metabolism in vitro.
J, Alanko +5 more
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Molecular Pharmacology, 1993
In male Syrian hamsters, an animal model for estradiol-induced carcinogenesis, 2-fluoroestradiol was not carcinogenic, whereas 4-fluoroestradiol induced kidney tumors after a prolonged latency period, compared with estradiol (100% tumor incidence), when ...
S. Ashburn, Xueliang Han, J. Liehr
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In male Syrian hamsters, an animal model for estradiol-induced carcinogenesis, 2-fluoroestradiol was not carcinogenic, whereas 4-fluoroestradiol induced kidney tumors after a prolonged latency period, compared with estradiol (100% tumor incidence), when ...
S. Ashburn, Xueliang Han, J. Liehr
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Metabolism of Catechol Estrogen Ethers in Man
The Journal of Clinical Endocrinology & Metabolism, 1970ABSTRACT The isomeric [14CH3] monomethyl ethers as well as the dimethyl ether of 2-hydroxyestrone-6,7-3H were prepared. Each double-labeled substrate was administered to man and its excretion and metabolism was followed. Conjugation was predominantly with some other substance than glucuronic acid and neither of the 2- or 3-monomethyl ethers was O ...
I, Yoshizawa, J, Fishman
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Inhibition of dihydropteridine reductase by catechol estrogens
Journal of Neuroscience Research, 1983AbstractCatechol estrogens, such as 2‐hydroxyestriol, 2‐hydroxyestradiol, and 2‐hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 × 10−6M. Catechol estrogens lose approximately half of their inhibitory potency if the C‐2 hydroxyl groups are methylated.
R S, Shen, C W, Abell
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METABOLISM OF CATECHOL ESTROGEN BY HUMAN ERYTHROCYTES
The Journal of Clinical Endocrinology & Metabolism, 1977In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone in vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone
G W, Bates +3 more
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Catechol Estrogen Analogs as Probes of Estrogen Carcinogenesis
1996The roles of estrogens in biochemical events leading to tumor formation remain to be fully elucidated. Induction of renal tumors in the estrogen-treated Syrian hamster offers a unique model to study. Catechol estrogen analogs have recently been prepared to examine the effects of A-ring substituents on estrogen metabolism and on estrogeninduced ...
Robert W. Brueggemeier +4 more
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In vitro metabolic conjugation of catechol estrogens
Journal of Steroid Biochemistry, 1984In vitro metabolic conjugation of the catechol estrogens, 2-hydroxyestrone and 4-hydroxyestrone, has been investigated by means of HPLC with electrochemical detection. Sulfation of 2-hydroxyestrone and 4-hydroxyestrone with the rat liver 105 000 g supernatant fortified with 3'-phosphoadenosine-5'-phosphosulfate provided the 2- and 4-monosulfates ...
K, Shimada +3 more
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