Results 11 to 20 of about 319,930 (224)

Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel [PDF]

Journal of Biological Chemistry, 2018
Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen ...
Wenzhen Ma, Xingjuan Chen, R. Cerne, S. Syed, J. Ficorilli, Over Cabrera, A. Obukhov, Alexander M. Efanov   +7 more
semanticscholar   +3 more sources

Circulating estradiol and its biologically active metabolites in endometriosis and in relation to pain symptoms

Frontiers in Endocrinology, 2023
ObjectivesEndometriosis (EM) is an estrogen-dominant inflammatory disease linked to infertility that affects women of reproductive age. EM lesions respond to hormonal signals that regulate uterine tissue growth and trigger inflammation and pain.
Jean-Philippe Emond, Patrick Caron, Maja Pušić, Véronique Turcotte, David Simonyan, Andrej Vogler, Joško Osredkar, Tea Lanišnik Rižner, Chantal Guillemette, Chantal Guillemette   +9 more
doaj   +1 more source

Do oral contraceptives affect young women's memory? Dopamine-dependent working memory is influenced by COMT genotype, but not time of pill ingestion.

PLoS ONE, 2021
BackgroundDespite the widespread use of oral contraceptives (OCs), and the well-documented influence of estrogens, notably 17β-estradiol (E2), on cognition, research relating OCs to working memory is limited and mixed. Two factors may contribute to these
Laura Gravelsins, Katherine Duncan, Gillian Einstein   +2 more
doaj   +2 more sources

Bioconversion of 4-hydroxyestradiol by extradiol ring-cleavage dioxygenases from Novosphingobium sp. PP1Y

Scientific Reports, 2023
Livestock breeding activities and pharmaceutical wastes lead to considerable accumulation of steroid hormones and estrogens in wastewaters. Here estrogens act as pro-cancerogenic agents and endocrine disruptors interfering with the sexual development of ...
Francesca Mensitieri, Andrea Bosso, Fabrizio Dal Piaz, Bruno Charlier, Eugenio Notomista, Viviana Izzo, Valeria Cafaro   +6 more
doaj   +1 more source

CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma. [PDF]

, 2015
BackgroundCytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has ...
Arichi, Naoko, Chang, Inik, Dahiya, Rajvir, Deng, Guoren, Fukuhara, Shinichiro, Hiraki, Miho, Hirata, Hiroshi, Majid, Shahana, Mitsui, Yozo, Shahryari, Varahram, Shiina, Hiroaki, Tanaka, Yuichiro, Wong, Darryn K, Yamamura, Soichiro, Yasumoto, Hiroaki   +14 more
core   +4 more sources

Alcohol drinking and mammary cancer: Pathogenesis and potential dietary preventive alternatives [PDF]

, 2014
Alcohol consumption is associated with an increased risk of breast cancer, increasing linearly even with a moderate consumption and irrespectively of the type of alcoholic beverage.
Castro, Gerardo Daniel, Castro, Jose Alberto   +1 more
core   +1 more source

Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry

Data in Brief, 2019
Analysis of catechol estrogens (2 & 4 hydroxy-estrone and estradiol) has proven troublesome by liquid chromatography tandem mass spectrometry due to their low concentrations, short half-lives and temperature-labile nature.
Nina Denver, Shazia Khan, Ioannis Stasinopoulos, Colin Church, Natalie Z.M. Homer, Margaret R. MacLean, Ruth Andrew   +6 more
doaj   +1 more source

Site-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changes

Scientific Reports, 2016
Proteins, covalently modified by catechol estrogens (CEs), were identified recently from the blood serum of diabetic patients and referred to as estrogenized proteins. Estrogenization of circulating insulin may occur and affect its molecular functioning.
Ming-chun Ku, Chieh-Ming Fang, Juei-Tang Cheng, Huei-Chen Liang, Tzu-Fan Wang, Chih-Hsing Wu, Chiao-Chen Chen, J. Tai, Shu-Hui Chen   +8 more
semanticscholar   +1 more source

Boronate Derivatives of Functionally Diverse Catechols: Stability Studies

Molecules, 2010
Benzeneboronate of catecholic carboxyl methyl esters, N-acetyldopamine, coumarin and catechol estrogens were prepared as crystalline derivatives in high yield.
Kamal Aziz Ketuly, A. Hamid A. Hadi
doaj   +1 more source

Suppressor effect of catechol-O-methyltransferase gene in prostate cancer.

PLoS ONE, 2021
Catechol-estrogens can cause genetic mutations and to counteract their oncogenicity, the catechol-O-methyltransferase (COMT) gene is capable of neutralizing these reactive compounds.
Yutaka Hashimoto, Marisa Shiina, Shigekatsu Maekawa, Taku Kato, Varahram Shahryari, Priyanka Kulkarni, Pritha Dasgupta, Soichiro Yamamura, Sharanjot Saini, Z Laura Tabatabai, Rajvir Dahiya, Yuichiro Tanaka   +11 more
doaj   +1 more source