Results 181 to 190 of about 138,106 (224)

Steroid and non-steroid UDP glucuronyltransferase: Glucuronidation of synthetic estrogens as steroids

Journal of Steroid Biochemistry, 1977
Abstract The hepatic microsomal glucuronidation profiles of eight substrates were investigated; p-nitrophenol (PNP), 4-methylumbelliferone (MUB), 1-naphthol (N), diethylstilbestrol (DES), β-estradiol (E2), estrone (E1), testosterone (T), and phenolphthalein (P).
G W, Lucier, O S, McDaniel
openaire   +2 more sources

Identification of a non-steroidal estrogen, equol, in the urine of pregnant macaques: correlation with steroidal estrogen excretion

Journal of Steroid Biochemistry, 1984
Macaque urinary estrogens at late pregnancy were separated by high performance liquid chromatography and quantified, both with radioimmunoassay and an in vitro uterine estrogen receptor assay. Five estrogens were measured. Four were steroids: estriol, estrone, 17 beta-estradiol, and 16 alpha-hydroxyestrone.
S L, Monfort, M A, Thompson, N M, Czekala, L H, Kasman, C H, Shackleton, B L, Lasley   +5 more
openaire   +2 more sources

The synthesis of new platinum(II) complexes linked to non-steroidal estrogens

Inorganica Chimica Acta, 1993
Abstract New platinum(II) complexes linked to triphenylethylene are efficiently synthesised in seven steps from desoxyanisoin with an overall yield exceeding 30%. The methodology described gives access to interesting non-steroidal cytotoxic estrogens designed for the treatment of breast cancer.
Penelope Wheeler, Gervais Bérubé
openaire   +1 more source

Aromatase Inhibitors for the Treatment of Breast Cancer: A Journey from the Scratch.

Anti-Cancer Agents in Medicinal Chemistry, 2020
BACKGROUND Estrogens are essential for the growth of breast cancer in case of premenopausal as well as in postmenopausal women. However, most of the breast cancer incidences are reported in postmenopausal women and the concurrent risk surges with ...
Pooja Ratre, Keerti Mishra, Amit Dubey, A. Vyas, A. Jain, Suresh Thareja   +5 more
semanticscholar   +1 more source

On Climacteric Symptoms and their Treatment with a New Non‐Steroidal Estrogen

International Journal of Gynecology & Obstetrics, 1975
Kullander, S. and Svanberg, L. (Dept of Obstetrics and Gynaecology, University of Lund, Malmö Allmänna Sjukhus, Malmö, Sweden). On climacteric symptoms and their treatment with a new non‐steroidal estrogen.Int J Gynaecol Obstet 13: 277–281, 1975.This study showed that P 1496 (Sandoz) a new nonsteroidal estrogenic preparation, is very effective in the ...
Stig Kullander, Lars Svanberg
openaire   +1 more source

The potent and selective inhibition of estrogen production by non-steroidal aromatase inhibitor, YM511

The Journal of Steroid Biochemistry and Molecular Biology, 1995
YM511 inhibited aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s: 0.4 and 0.12 nM, respectively). YM511 was about 3 times more potent than other aromatase inhibitors, such as CGS 16949A, CGS 20267 and R 76713. YM511 decreased the contents of estradiol stimulated by pregnant mare's serum gonadotropin in rat ovary
M, Kudoh, Y, Susaki, Y, Ideyama, T, Nanya, M, Okada, H, Shikama, T, Fujikura   +6 more
openaire   +2 more sources

Beneficiary and Adverse Effects of Phytoestrogens: A Potential Constituent of Plant Based Diet.

Current pharmaceutical design, 2020
BACKGROUND Phytoestrogens are non-endocrine, non-steroidal secondary derivatives of plants and consumed through plant-based diet also named as "dietary estrogens".
Vaadala Sridevi, Ponneri Naveen, V. Karnam, P. R. Reddy, M. Arifullah   +4 more
semanticscholar   +1 more source

Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor

The Journal of Steroid Biochemistry and Molecular Biology, 1990
CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1-3 micrograms/kg p.o.), CGS 20267 maximally inhibits estradiol production in vitro in LH-stimulated hamster ovarian tissue at 0.1 microM with an IC50 of 0.02 microM and does not significantly affect progesterone production up to ...
A S, Bhatnagar, A, Häusler, K, Schieweck, M, Lang, R, Bowman   +4 more
openaire   +2 more sources

ChemInform Abstract: The Synthesis of New Platinum(II) Complexes Linked to Non‐Steroidal Estrogens.

ChemInform, 1993
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P. WHEELER, G. BERUBE
openaire   +1 more source

Beyond estrogen: advances in tissue selective estrogen complexes and selective estrogen receptor modulators

Climacteric, 2019
Selective estrogen receptor modulators (SERMs) are synthetic non-steroidal agents which have variable estrogen agonist and antagonist activities in different target tissues. Tamoxifen is an anti-estrogen in the breast used for treatment and prevention of
J. Pinkerton, E. A. Conner
semanticscholar   +1 more source