Results 191 to 200 of about 138,106 (224)

ChemInform Abstract: Ylides of Heterocycles. Part 9. Potential Non‐Steroidal Estrogens and Antiestrogens.

Chemischer Informationsdienst, 1986
AbstractThe iodosobenzenes generated by treating (II) with Na2CO3 react with (I) to provide the iodoniumylides (III), whose thermal rearrangement to (IV) followed by reductive deiodination yields (V).
F. A. A. EL‐MARIAH, T. KAPPE
openaire   +1 more source

Possible role of phytoestrogens in breast cancer via GPER-1/GPR30 signaling.

Clinical science, 2018
Estrogens generated within endocrine organs and the reproductive system act as ligands for at least three types of estrogen receptors. Estrogen receptors α (ERα) and β (ERβ) belong to the so-called classical family of estrogen receptors, whereas the G ...
L. Molina, F. Bustamante, K. Bhoola, C. Figueroa, P. Ehrenfeld   +4 more
semanticscholar   +1 more source

Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors

The Journal of Steroid Biochemistry and Molecular Biology, 1993
The non-steroidal aromatase inhibitor CGS 20,267, at maximally effective doses in non-tumor bearing adult female rats, elicits endocrine effects mimicking those seen after surgical ovariectomy and thus induces a "medical" ovariectomy. We now report on studies characterizing the anti-tumor and endocrine effects of three orally active non-steroidal ...
K, Schieweck, A S, Bhatnagar, C, Batzl, M, Lang   +3 more
openaire   +2 more sources

Evaluation of piperidinoethoxy moiety as an antiestrogenic substituent in non-steroidal anti-estrogens: Fertility regulation

Bioorganic & Medicinal Chemistry Letters, 1997
Abstract A piperidinoethoxy substituent in non-steroidal antiestrogens has a relatively higher antiestrogenic effects as compared to a pyrrolidinoethoxy moiety. However, the antagonistic activity is more depended on the molecular geometry than the nature of the basic chain.
Sachi Tripathi, Indra Dwivedy, J.D Dhar, Anila Dwivedy, Suprabhat Ray   +4 more
openaire   +1 more source

The in vitro effects of several progestogens, estrogens and non-steroidal compounds with estrogenic activity on adenosine diphosphate induced guinea-pig platelet aggregation

Experientia, 1973
Des disperisions aqueuses de progestogenes et estrogenes stimulent l'agregation des plaquettes de cobaye produites par ADP in vitro. Le diethylstilbesterol et l'hexestrol qui ne sont pas des steroides, mais possedent une activite estrogenique, ont un effet inhibitoire sur l'agregation.
S, Clayman, R E, Gadd, D, Hébert
openaire   +2 more sources

Non-steroidal anti-estrogens in the treatment of breast cancer.

Current opinion in investigational drugs (London, England : 2000), 2007
The non-steroidal selective estrogen receptor modulator (SERM) tamoxifen has been used as standard first-line therapy for postmenopausal breast cancer since the 1970s, during which time over 400,000 lives have been saved. Nevertheless, much attention has been paid to the side effect profile of tamoxifen, particularly in terms of cardiovascular and ...
openaire   +1 more source

Simultaneous determination of non-steroidal anti-inflammatory drugs and natural estrogens in the mussels Mytilus edulis trossulus.

Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2019
Daniel Wolecki, Magda Caban, K. Pazdro, E. Mulkiewicz, P. Stepnowski, J. Kumirska   +5 more
semanticscholar   +1 more source

Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: limitations to the interpretation of experiments characterizing the activity of individual isomers.

Journal of Steroid Biochemistry, 1985
J. Katzenellenbogen, K. Carlson, B. Katzenellenbogen   +2 more
semanticscholar   +1 more source

Effects of phytoestrogens on reproductive organ health.

Archives of pharmacal research, 2022
S. Swathi Krishna, B. Kuriakose, P. Lakshmi   +2 more
semanticscholar   +1 more source

Structure-based drug design: synthesis, crystal structure, biological evaluation and docking studies of mono- and bis-benzo[b]oxepines as non-steroidal estrogens.

Bioorganic & Medicinal Chemistry, 2003
S. Sarkhel, Ashoke Sharon, V. Trivedi, P. Maulik, M. Singh, P. Venugopalan, S. Ray   +6 more
semanticscholar   +1 more source