Results 221 to 230 of about 7,787 (278)
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Early-estrogen syndrome in the rat by the non-steroidal estrogen diethylstilbestrol
Experientia, 1967Typisches, durch Ostrogene (fruhpostnatale Periode) bei weiblichen und mannlichen Ratten induziertes Syndrom, wird auch durch nicht-steroidales Ostrogen, das Diathylstilbostrol, ausgelost. Auffallend wellenformige Granulosazellenschicht in den grossen Graafschen Follikeln.
J, Presl +3 more
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Developmental evaluation of a potential non-steroidal estrogen: triclosan
Marine Environmental Research, 2000Triclosan is an antibacterial agent commonly used in industry and often detected in waste-water effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bisphenol A).
C M, Foran, E R, Bennett, W H, Benson
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Bioorganic & Medicinal Chemistry, 2003
Estrogens regulate many biological functions, often acting in a tissue-selective manner. Their tissue-selective action is believed to involve differential estrogen action through the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, as well as differential interaction of the ligand-receptor complexes with promoters and coregulator proteins.
Usha, Ghosh +6 more
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Estrogens regulate many biological functions, often acting in a tissue-selective manner. Their tissue-selective action is believed to involve differential estrogen action through the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, as well as differential interaction of the ligand-receptor complexes with promoters and coregulator proteins.
Usha, Ghosh +6 more
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The Journal of Steroid Biochemistry and Molecular Biology, 1997
Estrogen receptor (ER), a member of the nuclear receptor superfamily, exerts prominent physiological roles in both humans and other species by acting directly as a transcription factor, altering nuclear gene expression. One peculiarity of estrogenic regulation is that it is affected by a wide variety of non-steroidal compounds in addition to the ...
C Y, Meyers, H G, Lutfi, S, Adler
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Estrogen receptor (ER), a member of the nuclear receptor superfamily, exerts prominent physiological roles in both humans and other species by acting directly as a transcription factor, altering nuclear gene expression. One peculiarity of estrogenic regulation is that it is affected by a wide variety of non-steroidal compounds in addition to the ...
C Y, Meyers, H G, Lutfi, S, Adler
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On Climacteric Symptoms and their Treatment with a New Non‐Steroidal Estrogen
International Journal of Gynecology & Obstetrics, 1975Kullander, S. and Svanberg, L. (Dept of Obstetrics and Gynaecology, University of Lund, Malmö Allmänna Sjukhus, Malmö, Sweden). On climacteric symptoms and their treatment with a new non‐steroidal estrogen.Int J Gynaecol Obstet 13: 277–281, 1975.This study showed that P 1496 (Sandoz) a new nonsteroidal estrogenic preparation, is very effective in the ...
Stig Kullander, Lars Svanberg
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Journal of Steroid Biochemistry, 1984
Macaque urinary estrogens at late pregnancy were separated by high performance liquid chromatography and quantified, both with radioimmunoassay and an in vitro uterine estrogen receptor assay. Five estrogens were measured. Four were steroids: estriol, estrone, 17 beta-estradiol, and 16 alpha-hydroxyestrone.
S L, Monfort +5 more
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Macaque urinary estrogens at late pregnancy were separated by high performance liquid chromatography and quantified, both with radioimmunoassay and an in vitro uterine estrogen receptor assay. Five estrogens were measured. Four were steroids: estriol, estrone, 17 beta-estradiol, and 16 alpha-hydroxyestrone.
S L, Monfort +5 more
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Testicular toxicity and mutagenicity of steroidal and non-steroidal estrogens in the male mouse
Mutation Research/Genetic Toxicology, 1991The mutagenicity and toxicity of diethylstilbestrol (DES), 17 beta-estradiol and zeranol on the male mouse germ cells were investigated with meiotic micronucleus assays in vivo and in vitro, sperm-head abnormality test and morphometry. Further, the developmental effects of DES on testicular morphology were explored.
L, Pylkkänen +3 more
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Journal of Steroid Biochemistry, 1977
Abstract The hepatic microsomal glucuronidation profiles of eight substrates were investigated; p-nitrophenol (PNP), 4-methylumbelliferone (MUB), 1-naphthol (N), diethylstilbestrol (DES), β-estradiol (E2), estrone (E1), testosterone (T), and phenolphthalein (P).
G W, Lucier, O S, McDaniel
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Abstract The hepatic microsomal glucuronidation profiles of eight substrates were investigated; p-nitrophenol (PNP), 4-methylumbelliferone (MUB), 1-naphthol (N), diethylstilbestrol (DES), β-estradiol (E2), estrone (E1), testosterone (T), and phenolphthalein (P).
G W, Lucier, O S, McDaniel
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The synthesis of non-steroidal estrogen receptor binding compounds labeled with 80mBr
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1986Estrogen receptor (ER) binding radiopharmaceuticals have potential for use in the diagnosis and treatment of cancers of the female reproductive system. Two triphenylethylene derivatives based on the structure of hydroxytamoxifen 4, a high ER binding metabolite of tamoxifen 5, have been prepared: 1-(4-dimethylaminoethoxy)phenyl]-1-(4-hydroxy)phenyl-2 ...
R H, Seevers +3 more
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Non-Steroidal Subtype Selective Estrogens
Current Medicinal Chemistry, 2005The biological effects of estrogens are thought to be mediated by two receptors referred to as ERalpha and ERbeta. In recent years significant efforts have been devoted to the design of subtype selective ligands. These ligands are valuable tools to establish the precise biological role of each of the subtypes and to develop new generations of ...
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