Results 231 to 240 of about 12,973 (282)
Some of the next articles are maybe not open access.
Journal of Steroid Biochemistry, 1977
Abstract The hepatic microsomal glucuronidation profiles of eight substrates were investigated; p-nitrophenol (PNP), 4-methylumbelliferone (MUB), 1-naphthol (N), diethylstilbestrol (DES), β-estradiol (E2), estrone (E1), testosterone (T), and phenolphthalein (P).
G W, Lucier, O S, McDaniel
openaire +2 more sources
Abstract The hepatic microsomal glucuronidation profiles of eight substrates were investigated; p-nitrophenol (PNP), 4-methylumbelliferone (MUB), 1-naphthol (N), diethylstilbestrol (DES), β-estradiol (E2), estrone (E1), testosterone (T), and phenolphthalein (P).
G W, Lucier, O S, McDaniel
openaire +2 more sources
Journal of Steroid Biochemistry, 1984
Macaque urinary estrogens at late pregnancy were separated by high performance liquid chromatography and quantified, both with radioimmunoassay and an in vitro uterine estrogen receptor assay. Five estrogens were measured. Four were steroids: estriol, estrone, 17 beta-estradiol, and 16 alpha-hydroxyestrone.
S L, Monfort +5 more
openaire +2 more sources
Macaque urinary estrogens at late pregnancy were separated by high performance liquid chromatography and quantified, both with radioimmunoassay and an in vitro uterine estrogen receptor assay. Five estrogens were measured. Four were steroids: estriol, estrone, 17 beta-estradiol, and 16 alpha-hydroxyestrone.
S L, Monfort +5 more
openaire +2 more sources
Journal of Molecular Structure, 2008
Abstract An experimental charge density analysis has been carried out on two synthetic estrogens, diethylstilbestrol (DES) and dienestrol (DNS), to further investigate the alignment and binding of estrogenic compounds to the estrogen receptor, and to also establish a relationship between the biological function and the electronic properties of ...
Eric J. Yearley +3 more
openaire +1 more source
Abstract An experimental charge density analysis has been carried out on two synthetic estrogens, diethylstilbestrol (DES) and dienestrol (DNS), to further investigate the alignment and binding of estrogenic compounds to the estrogen receptor, and to also establish a relationship between the biological function and the electronic properties of ...
Eric J. Yearley +3 more
openaire +1 more source
The synthesis of new platinum(II) complexes linked to non-steroidal estrogens
Inorganica Chimica Acta, 1993Abstract New platinum(II) complexes linked to triphenylethylene are efficiently synthesised in seven steps from desoxyanisoin with an overall yield exceeding 30%. The methodology described gives access to interesting non-steroidal cytotoxic estrogens designed for the treatment of breast cancer.
Penelope Wheeler, Gervais Bérubé
openaire +1 more source
On Climacteric Symptoms and their Treatment with a New Non‐Steroidal Estrogen
International Journal of Gynecology & Obstetrics, 1975Kullander, S. and Svanberg, L. (Dept of Obstetrics and Gynaecology, University of Lund, Malmö Allmänna Sjukhus, Malmö, Sweden). On climacteric symptoms and their treatment with a new non‐steroidal estrogen.Int J Gynaecol Obstet 13: 277–281, 1975.This study showed that P 1496 (Sandoz) a new nonsteroidal estrogenic preparation, is very effective in the ...
Stig Kullander, Lars Svanberg
openaire +1 more source
Current Medicinal Chemistry, 2010
Herbivorous and omnivorous vertebrates have evolved in the presence of a variety of phytoestrogens, i.e., plant-derived compounds that can mimic, modulate or disrupt the actions of endogenous estrogens. Since the discovery of the estrus-inducing effects of some plant products in 1926, considerable effort has been devoted to the isolation and structural
T, Lóránd, E, Vigh, J, Garai
openaire +2 more sources
Herbivorous and omnivorous vertebrates have evolved in the presence of a variety of phytoestrogens, i.e., plant-derived compounds that can mimic, modulate or disrupt the actions of endogenous estrogens. Since the discovery of the estrus-inducing effects of some plant products in 1926, considerable effort has been devoted to the isolation and structural
T, Lóránd, E, Vigh, J, Garai
openaire +2 more sources
The Journal of Steroid Biochemistry and Molecular Biology, 1995
YM511 inhibited aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s: 0.4 and 0.12 nM, respectively). YM511 was about 3 times more potent than other aromatase inhibitors, such as CGS 16949A, CGS 20267 and R 76713. YM511 decreased the contents of estradiol stimulated by pregnant mare's serum gonadotropin in rat ovary
M, Kudoh +6 more
openaire +2 more sources
YM511 inhibited aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s: 0.4 and 0.12 nM, respectively). YM511 was about 3 times more potent than other aromatase inhibitors, such as CGS 16949A, CGS 20267 and R 76713. YM511 decreased the contents of estradiol stimulated by pregnant mare's serum gonadotropin in rat ovary
M, Kudoh +6 more
openaire +2 more sources
Testicular toxicity and mutagenicity of steroidal and non-steroidal estrogens in the male mouse
Mutation Research/Genetic Toxicology, 1991The mutagenicity and toxicity of diethylstilbestrol (DES), 17 beta-estradiol and zeranol on the male mouse germ cells were investigated with meiotic micronucleus assays in vivo and in vitro, sperm-head abnormality test and morphometry. Further, the developmental effects of DES on testicular morphology were explored.
L, Pylkkänen +3 more
openaire +2 more sources
The Journal of Steroid Biochemistry and Molecular Biology, 1990
CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1-3 micrograms/kg p.o.), CGS 20267 maximally inhibits estradiol production in vitro in LH-stimulated hamster ovarian tissue at 0.1 microM with an IC50 of 0.02 microM and does not significantly affect progesterone production up to ...
A S, Bhatnagar +4 more
openaire +2 more sources
CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1-3 micrograms/kg p.o.), CGS 20267 maximally inhibits estradiol production in vitro in LH-stimulated hamster ovarian tissue at 0.1 microM with an IC50 of 0.02 microM and does not significantly affect progesterone production up to ...
A S, Bhatnagar +4 more
openaire +2 more sources
ChemInform Abstract: The Synthesis of New Platinum(II) Complexes Linked to Non‐Steroidal Estrogens.
ChemInform, 1993AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P. WHEELER, G. BERUBE
openaire +1 more source