Results 241 to 250 of about 12,973 (282)
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Chemischer Informationsdienst, 1986
AbstractThe iodosobenzenes generated by treating (II) with Na2CO3 react with (I) to provide the iodoniumylides (III), whose thermal rearrangement to (IV) followed by reductive deiodination yields (V).
F. A. A. EL‐MARIAH, T. KAPPE
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AbstractThe iodosobenzenes generated by treating (II) with Na2CO3 react with (I) to provide the iodoniumylides (III), whose thermal rearrangement to (IV) followed by reductive deiodination yields (V).
F. A. A. EL‐MARIAH, T. KAPPE
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The Journal of Steroid Biochemistry and Molecular Biology, 1993
The non-steroidal aromatase inhibitor CGS 20,267, at maximally effective doses in non-tumor bearing adult female rats, elicits endocrine effects mimicking those seen after surgical ovariectomy and thus induces a "medical" ovariectomy. We now report on studies characterizing the anti-tumor and endocrine effects of three orally active non-steroidal ...
K, Schieweck +3 more
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The non-steroidal aromatase inhibitor CGS 20,267, at maximally effective doses in non-tumor bearing adult female rats, elicits endocrine effects mimicking those seen after surgical ovariectomy and thus induces a "medical" ovariectomy. We now report on studies characterizing the anti-tumor and endocrine effects of three orally active non-steroidal ...
K, Schieweck +3 more
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Bioorganic & Medicinal Chemistry Letters, 1997
Abstract A piperidinoethoxy substituent in non-steroidal antiestrogens has a relatively higher antiestrogenic effects as compared to a pyrrolidinoethoxy moiety. However, the antagonistic activity is more depended on the molecular geometry than the nature of the basic chain.
Sachi Tripathi +4 more
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Abstract A piperidinoethoxy substituent in non-steroidal antiestrogens has a relatively higher antiestrogenic effects as compared to a pyrrolidinoethoxy moiety. However, the antagonistic activity is more depended on the molecular geometry than the nature of the basic chain.
Sachi Tripathi +4 more
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Endocrinology, 1958
MER-25, l-(p-2-Diethylaminoethoxyphenyl)-l-phenyl-2-p-methoxyphenyl ethanol, blocks the response of estrogen target organs to the stimulating action of estrogens. The estrogen antagonism activity of MER-25 has been demonstrated in intact and castrate rats, mice and monkeys and in chicks and rabbits.
LEONARD J. LERNER +2 more
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MER-25, l-(p-2-Diethylaminoethoxyphenyl)-l-phenyl-2-p-methoxyphenyl ethanol, blocks the response of estrogen target organs to the stimulating action of estrogens. The estrogen antagonism activity of MER-25 has been demonstrated in intact and castrate rats, mice and monkeys and in chicks and rabbits.
LEONARD J. LERNER +2 more
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Experientia, 1973
Des disperisions aqueuses de progestogenes et estrogenes stimulent l'agregation des plaquettes de cobaye produites par ADP in vitro. Le diethylstilbesterol et l'hexestrol qui ne sont pas des steroides, mais possedent une activite estrogenique, ont un effet inhibitoire sur l'agregation.
S, Clayman, R E, Gadd, D, Hébert
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Des disperisions aqueuses de progestogenes et estrogenes stimulent l'agregation des plaquettes de cobaye produites par ADP in vitro. Le diethylstilbesterol et l'hexestrol qui ne sont pas des steroides, mais possedent une activite estrogenique, ont un effet inhibitoire sur l'agregation.
S, Clayman, R E, Gadd, D, Hébert
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Rapid Communications in Mass Spectrometry, 2002
Abstract It is suspected that all the natural estrogens occurring in the human body, as well as dietary and synthetic estrogens, diversely affect the endocrine system depending on their exposure patterns. More rapid, reliable and accurate measurements of these compounds in various biological matrices are thus ...
Man Ho, Choi +4 more
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Abstract It is suspected that all the natural estrogens occurring in the human body, as well as dietary and synthetic estrogens, diversely affect the endocrine system depending on their exposure patterns. More rapid, reliable and accurate measurements of these compounds in various biological matrices are thus ...
Man Ho, Choi +4 more
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Non-steroidal anti-estrogens in the treatment of breast cancer.
Current opinion in investigational drugs (London, England : 2000), 2007The non-steroidal selective estrogen receptor modulator (SERM) tamoxifen has been used as standard first-line therapy for postmenopausal breast cancer since the 1970s, during which time over 400,000 lives have been saved. Nevertheless, much attention has been paid to the side effect profile of tamoxifen, particularly in terms of cardiovascular and ...
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Non Steroidal Estrogen Antagonists: Current Status and Future Perspectives
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2001Bentham Science Publisher K. Hajela +2 more
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