Results 101 to 110 of about 163,518 (339)

Ovarian Function Restoration with Biomimetic Scaffold Incorporating Angiogenic Molecules and Antioxidant in Chemotherapy‐Induced Perimenopausal Model

Advanced Healthcare Materials, EarlyView.
This study developed a biomimetic scaffold incorporating PDRN and melatonin to restore ovarian function in chemotherapy‐induced premature ovarian insufficiency, enhancing cell survival, folliculogenesis, and hormone normalization, while improving fertility rates and offspring in a mouse model, offering a promising strategy for ovarian function ...
Da‐Seul Kim, Dong Seok Jeong, So‐Yeon Park, Ji‐Won Jung, Jeoung Eun Lee, Jun‐Kyu Lee, Seung‐Woon Baek, Dong Ryul Lee, Dong Keun Han   +8 more
wiley   +1 more source

Exploiting the Unique Properties of Lanthanide Complexes as FRET Probes: from Quantitation to Protein Dynamics

Analysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Lanthanide complexes are ideal donors for FRET (Förster resonance energy transfer) assays with a variety of applications from easy‐to‐use quantitation of proteins to sophisticated experiments giving real‐time information on the movement of proteins. This Review article introduces the principles of using such assays before surveying the full scope of ...
Simon Wheeler, Stephen J. Butler
wiley   +1 more source

Duplicated membrane estrogen receptors in the European sea bass (Dicentrarchus labrax): Phylogeny, expression and regulation throughout the reproductive cycle [PDF]

, 2018
The numerous estrogen functions reported across vertebrates have been classically explained by their binding to specific transcription factors, the nuclear estrogen receptors (ERs).
Alvarado, M. Victoria, Andrade, André, Estêvão, M. Dulce, Felip, Alicia, Pinto, Patricia IS, Power, Deborah   +5 more
core   +1 more source

A Novel 3D High‐Throughput Phenotypic Drug Screening Pipeline to Identify Drugs with Repurposing Potential for the Treatment of Ovarian Cancer

Advanced Healthcare Materials, EarlyView.
Ovarian cancer's high recurrence and therapy resistance demand new strategies. A high‐throughput drug screening pipeline using 3D spheroids, which showed poor concordance with 2D models, identified rapamycin as a promising candidate. In combination with cisplatin, rapamycin demonstrated significant in vitro and in vivo efficacy, highlighting the ...
Nazanin Karimnia, Amy L. Wilson, Brittany R. Doran, Jennie Do, Amelia Matthews, Gwo Y. Ho, Magdalena Plebanski, Thomas W. Jobling, Andrew N. Stephens, Maree Bilandzic   +9 more
wiley   +1 more source

Male reproductive health and environmental xenoestrogens [PDF]

, 1996
EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or ...
A Giwercman, Ansell PE, Avellan L, B Jégou, Baird DD, Baumrucker GO, Berkowitz GD, Berkowitz GS, Bibbo M, Bigler WJ, Bj N, Blom K, Bostofte E, Bradbury RB, Bromage NR, Brown LM, Buemann B, Campbell DM, Cassidy A, Chung CS, Clemens MJ, Conover MR, Copeland PA, Czeizel A, Depue RH, Driscoll SG, E Rajpert-De Meyts, Forman D, Fox GA, Freeman HC, Frst P, Fry DM, Gray LEJ, Gray LEJ, Greco TL, H Leffers, Hakulinen T, Halevi HS, Harris LE, Hautau ER, Henderson BE, Hirasing RA, Hohlbein R, Hsieh J-T, Ikeda Y, J A McLachlan, J C Larsen, J Müller, J Sumpter, J Toppari, Jennings ML, Jost A, Kallen B, Kallen B, Korach KS, Kupfer D, L J Guillette, Leatherland JF, Leatherland JF, McDonnell DP, McIntosh R, N E Skakkebaek, N Keiding, Newbold RR, O Meyer, P Christiansen, P Grandjean, P Jouannet, Panayotou PC, Pearce N, Peterson RE, Pohjanvirta R, R Sharpe, Rey RA, Schumacher GFB, Scully RE, Sell S, Soto AM, Sweet RA, T K Jensen, T Scheike, Thomas KB, Thomas KB, Thorup J, Tryphonas L, Turscott B, Vessey MP, Wallace HM, Ward B, Wilkinson TJ   +89 more
core   +2 more sources

Computational Estimates of Binding Affinities for Estrogen Receptor Isoforms in Rainbow Trout [PDF]

arXiv, 2009
Molecular dynamics simulations were used to determine the binding affinities between between the hormone 17 beta-estradiol (E2) and different estrogen receptor (ER) isoforms in the rainbow trout, Oncorhynchus mykiss. Previous phylogenetic analysis indicates that a whole genome duplication prior to the divergence of ray-finned fish led to two distinct ...
arxiv  

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Morphologies in‐between: The impact of the first steps on the human talus

The Anatomical Record, Volume 306, Issue 1, Page 124-142, January 2023., 2023
Abstract Objective The development of bipedalism is a very complex activity that contributes to shaping the anatomy of the foot. The talus, which starts ossifying in utero, may account for the developing stages from the late gestational phase onwards.
Carla Figus, Nicholas B. Stephens, Rita Sorrentino, Eugenio Bortolini, Simona Arrighi, Owen A. Higgins, Federico Lugli, Giulia Marciani, Gregorio Oxilia, Matteo Romandini, Sara Silvestrini, Fabio Baruffaldi, Maria Giovanna Belcastro, Federico Bernardini, Anna Festa, Tamás Hajdu, Orsolya Mateovics‐László, Ildiko Pap, Tamás Szeniczey, Claudio Tuniz, Timothy M. Ryan, Stefano Benazzi   +21 more
wiley   +1 more source

Sex Hormones and Healthy Psychological Aging in Women

Frontiers in Aging Neuroscience, 2018
Besides their key role in reproduction, estrogens have effects in several organs in the body, as confirmed by the identification of estrogen receptors (ER) in multiple tissues.
Esperanza Navarro-Pardo, Carol A. Holland, Antonio Cano   +2 more
doaj   +1 more source

New approaches for estimating risk from exposure to diethylstilbestrol. [PDF]

, 1999
A subgroup from a National Institute of Environmental Health Sciences, workshop concerned with characterizing the effects of endocrine disruptors on human health at environmental exposure levels considered the question, If diethylstilbestrol (DES) were ...
Cunha, GR, Forsberg, JG, Golden, R, Haney, A, Iguchi, T, Newbold, R, Swan, S, Welshons, W   +7 more
core   +2 more sources