Impact of extended endocrine therapy for patients with risk factors for late recurrence in estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer after 5 years of endocrine therapy [PDF]
Masahiro Ito +6 more
openalex +1 more source
Association with replication between estrogen-related receptor γ (ESRRγ) Polymorphisms and bone phenotypes in women of European ancestry [PDF]
, 2009 Latifa Elfassihi +5 more
openalex +1 more source
Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro
Advanced Science, EarlyView.A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner +8 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
The Impact of Sex Hormones on Transcranial Magnetic Stimulation Against the Oxidative Stress in the Pathogenesis of Multiple Sclerosis. [PDF]
BiomoleculesEscribano BM +9 more
europepmc +1 more source
Sensitivity of a Tier I Screening Battery Compared to an in Utero Exposure for Detecting the Estrogen Receptor Agonist 17β-Estradiol [PDF]
, 1998 John C. O’Connor +4 more
openalex +1 more source
Advanced Science, EarlyView.This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao +10 more
wiley +1 more source
Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan. [PDF]
Front Endocrinol (Lausanne)Lee AA, Den Hartigh LJ.
europepmc +1 more source
Mechanism of estrogenic action in acromegaly [PDF]
, 1969 Ernest Schwartz +3 more
openalex +1 more source