The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells. [PDF]
PLoS ONE, 2012 Estrone and estradiol are both estrogens with estrone being the less potent form and estradiol being the most potent estrogen. The binding of the latter to cellular regulatory elements stimulates the proliferation of breast cancer cells.
Chen-Yan Zhang +3 more
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The Scientific World Journal, 2012 Background. The link between endogenous estrogen, coronary artery disease (CAD), and death in postmenopausal women is uncertain. We analyzed the association between death and blood levels of estrone in postmenopausal women with known coronary artery ...
Antonio de Padua Mansur +7 more
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A native bacterial consortium degrades estriol in domestic sewage and activated sludge via the 4,5-seco pathway and requires estriol to retain its biodegradation phenotype [PDF]
Microbiology SpectrumEstriol (E3) is one of the natural steroid estrogens commonly detected in wastewater. Although microbial biodegradation is a key process for removal of steroid estrogens during wastewater treatment, estriol biodegradation, and biotransformation ...
Jaleela S. Hashem +6 more
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Voltammetric Determination of the Total Content of the Most Commonly Occurring Estrogens in Water Media [PDF]
MoleculesEstrogens in aquatic environments pose significant ecological and health risks due to their cumulative effects rather than individual impacts. This study investigates the voltammetric behavior of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α ...
Jaromíra Chýlková +4 more
doaj +2 more sources
Urinary Glyphosate Concentrations and Serum Sex Hormones in a Nationally Representative U.S. Sample: NHANES 2017–2018 [PDF]
LifeGlyphosate and glyphosate-based herbicides (GBHS) are the most widely used herbicides worldwide, yet their potential endocrine-disrupting effects in humans remain inadequately studied.
Wen-Yang Wu +4 more
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Frontiers in Endocrinology, 2011 Endocrine disrupting chemicals are adversely affecting the reproductive health and metabolic status of aquatic vertebrates. Estrone is often the dominant natural estrogen in urban sewage, yet little is known about its environmental fate and biological ...
Vance L Trudeau +12 more
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16-Hydroxylation of Estrone-3-Sulfate and Estrone in the Guinea Pig in Vivo*
Endocrinology, 1978 [6,7-3H]Estrone-3-sulfate or [6,7-3H]-estrone of high specific activity was injected into adult female English Shorthair guinea pigs. Blood, liver, kidney, gall bladder bile, and urine were obtained and investigated for metabolites. Chromatographic procedures followed by enzymatic or solvolytic cleavage of conjugates and subsequent crystallization with
R. Hobkirk, Mona Nilsen, Jiro Mori
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Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism [PDF]
Molecular MetabolismObjective: Recent modifications to glucagon-like peptide 1 (GLP-1), known for its insulinotropic and satiety-inducing effects, have focused on conjugating small molecules to enable selective delivery into GLP-1R+ tissues to achieve targeted synergy and ...
Callum Coupland +17 more
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Endogenous sex hormone levels are associated with the revised Framingham Stroke Risk Profile in postmenopausal women: a longitudinal study in a Swedish cohort [PDF]
BMC Endocrine DisordersBackground Endogenous sex hormones in postmenopausal women have been associated with risk of cardiovascular diseases. The aim of this study was to determine the association between endogenous sex hormones and the revised Framingham Stroke Risk Profile ...
Kristin Ottarsdottir +6 more
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The Role of Estrone in Feminizing Hormone Treatment
Journal of Clinical Endocrinology and Metabolism, 2021 Context In trans women, hormone treatment induces feminization; however, the degree of feminization varies from person to person. A possible contributing factor could be estrone, a weak estrogen that interferes with the estrogen receptor.
Marieke Tebbens +4 more
semanticscholar +1 more source