Results 1 to 10 of about 18,229 (121)

Harnessing Bifunctional N‐Benzoyloxyamides for Photoredox Amidative Dual Functionalizations of Alkenes

Angewandte Chemie, EarlyView.
A novel photocatalytic strategy is presented for intermolecular amidative dual functionalization of alkenes using N‐benzoyloxyamides as bifunctional N─O reagents. The method enables efficient olefin 1,2‐amidooxygenation and significantly extends its reactivity to encompass amidoazidation, diamination, and formal anti‐Markovnikov hydroamidation.
Harin Ryoo, Hyeyun Keum, Dongwook Kim, Sukbok Chang   +3 more
wiley   +2 more sources

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Angewandte Chemie, EarlyView.
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmüller, Mark A. Wilson, David B. Berkowitz   +15 more
wiley   +2 more sources

Comprehensive genetic analysis of poorly differentiated gastric cancer in young females

Annals of Gastroenterological Surgery, EarlyView.
Although the involvement of female sex hormones in the development of poorly differentiated gastric cancer in young females is controversial, our detailed analysis using RNA‐seq suggested that the female sex hormone, β‐estradiol plays a role in the development of poorly differentiated gastric cancer in young females. Abstract Aim The reasons behind the
Nobuhiro Nakazawa, Takehiko Yokobori, Yohei Morishita, Akinobu Echigo, Reika Kawabata‐Iwakawa, Akiharu Kimura, Akihiko Sano, Makoto Sakai, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Kupfer(II)‐photokatalysierte Radikalannellierung von Nitroalkanen mit Alkenen oder Alkinen zur Synthese von Isoxazolinen und Isoxazolen

Angewandte Chemie, EarlyView.
Wir stellen ein Cu(II)‐photokatalytisches Verfahren vor, bei dem handelsübliche Nitroalkane für die Synthese von Isoxazolinen und Isoxazolen aus Alkenen bzw. Alkinen verwendet werden. Detaillierte mechanistische Untersuchungen ergaben, dass der breite Substratbereich, der sowohl aktivierte als auch nicht aktivierte Alkene und Alkine umfasst, auf einen ...
Sunaina Sardana, Aryaman Pattanaik, Julia Rehbein, Oliver Reiser   +3 more
wiley   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Copper(II)‐Photocatalyzed Radical Anellation of Nitroalkanes with Alkenes or Alkynes for the Synthesis of Isoxazolines and Isoxazoles

Angewandte Chemie International Edition, EarlyView.
We present a Cu(II)‐photocatalyzed method that employs commercially available nitroalkanes for the synthesis of isoxazolines and isoxazoles from alkenes and alkynes, respectively. Detailed mechanistic investigations revealed that the broad substrate scope, encompassing both activated and unactivated alkenes and alkynes, is attributable to a radical ...
Sunaina Sardana, Aryaman Pattanaik, Julia Rehbein, Oliver Reiser   +3 more
wiley   +1 more source

Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates

ChemCatChem, EarlyView.
The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell, Cosmina Bohan, Alexandra Pop, Esteban P. Urriolabeitia   +3 more
wiley   +1 more source

In Situ Generation of Alkyl–λ3–Iodanes as Soft and Highly Reactive Electrophiles

ChemistryEurope, EarlyView.
A convenient and practical method for the clean generation of alkyl–λ3–iodanes is reported using tetraalkylsilanes and iodine tris(trifluoroacetate). An in situ‐generated methyl–λ3–iodane works as a soft and highly electrophilic methylation reagent, which enables methylation of tertiary sulfonamides at low temperatures and following transamidation and ...
Rina Katsuta, Takayuki Watanabe, Keitaro Matsuoka, Keito Watanabe, Kosuke Higashida, Tatsuhiko Yoshino, Shigeki Matsunaga   +6 more
wiley   +1 more source

Functionalized in Triplicate: A Ring‐By‐Ring Approach to Tailored Prodiginine Derivatives for Site‐Specific Conjugation Through Click Chemistry

Chemistry – A European Journal, EarlyView.
Prodigiosin is a potent cytotoxic alkaloid but lacks target selectivity. We advance functionalization of all three pyrrole rings of prodigiosin to enable site‐specific conjugation via click chemistry. The presented azide‐ and maleimide‐functionalized prodiginines are suitable for generating covalent prodiginine conjugates and attaching auspicious ...
T. Moritz Weber, Jörg Pietruszka
wiley   +1 more source

Diclofenac Detection via Inner‐Filter Effect Using Pyridine‐Modified Triphenylene

ChemPlusChem, EarlyView.
The synthesis of hexa‐pyridine triphenylene derivatives via Suzuki‐coupling reaction and their application toward the sensing of diclofenac have been studied for the first time. The 3PY and 4PY are selective for diclofenac over the other commonly prescribed pharmaceuticals and hormones tested. Triphenylene derivatives 3PY (2,3,6,7,10,11‐hexa(pyridine‐3‐
Navdeep Kajal, Amar Raj, Rajendhraprasad Tatikonda, Jan Lundell, Matti Haukka   +4 more
wiley   +1 more source