Results 181 to 190 of about 68,964 (236)
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Comparative Fate of Estrone and Estrone Sulfate in Man
The Journal of Clinical Endocrinology & Metabolism, 1973Estrone-14C and estrone sulfate-3H were simultaneously injected into a 37-yr-old woman and disposition of the two isotopes was followed. The products of estrone sulfate were excreted in urine more rapidly and to a greater extent than those of the coadministered estrone.
J, Fishman, L, Hellman
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The Journal of Steroid Biochemistry and Molecular Biology, 1995
Estrogen levels in breast tumors of post-menopausal women are at least 10 times higher than estrogen levels in plasma. The high level of estrogen in these tumors is postulated to be due to in situ formation of estrogen, possibly through conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.
K W, Selcer, P K, Li
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Estrogen levels in breast tumors of post-menopausal women are at least 10 times higher than estrogen levels in plasma. The high level of estrogen in these tumors is postulated to be due to in situ formation of estrogen, possibly through conversion of estrone sulfate to estrone by the enzyme estrone sulfatase.
K W, Selcer, P K, Li
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Estrone and Estrone Sulfate Concentrations in Milk and Milk Fractions
Journal of the Academy of Nutrition and Dietetics, 2012Dairy products naturally contain estrogens, and some consumer groups contend these estrogens cause adverse health effects. The objectives of this research were to characterize estrone (E(1)) and estrone sulfate (E(1)S) concentrations in milk from a large number of individual cows, in skim and fat fractions of milk, and in retail milk to provide food ...
Ann L, Macrina +3 more
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Estrone Sulfate, Estrone, Estradiol and Estriol Plasma Levels in Human Pregnancy
The Journal of Clinical Endocrinology & Metabolism, 1972ABSTRACT Estrone sulfate, estrone, estradiol and estriol were measured through the course of pregnancy in 85 women. Of the unconjugated estrogens, estradiol had the highest plasma concentration, being approximately twice that of estrone and four times that of estriol. Estrone sulfate level was twice that of estradiol.
D L, Loriaux +3 more
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An expeditious synthesis of estrone
Journal of Steroid Biochemistry, 1975Abstract The Tris annelating agent, 6-(2-methyl-6-pyridyl-hex-l-ene-3-one), has been synthesized in four steps from the readily available 2,6-lutidine. To this 12-carbon ensemble is added, in a Michael fashion, 2-methycyclopentane-1,3-dione. The prochiral pyridyltrione, so produced, can be cyclized to afford 4-(2-α-picolylethyl)-hydrind-4-ene-3,7 ...
S, Danishefsky, P, Cain
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Estrone Sulfatase and Its Inhibitors
Anti-Cancer Agents in Medicinal Chemistry, 2009A high proportion (∼40%) of breast cancers are hormone-dependent and it is the female hormone estradiol (E2) that is believed to play a key role in the initiation, promotion and progression of this disease. In the fight against this disease, compounds which are potent inhibitors of the cytochrome P-450 enzyme aromatase (AR) (which catalyses the ...
Kwabina, Aidoo-Gyamfi +3 more
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A Concise Route to (+)-Estrone
Organic Letters, 2000A concise route to the Torgov diene, the key intermediate of estrone, has been devised using a chiral dioxycyclopentenone as the starting material by employing a sequence of five steps of reactions involving a Lewis acid-mediated Diels-Alder reaction with Dane's diene.
, Tanaka +3 more
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Formal Enantioselective Synthesis of (+)-Estrone
Organic Letters, 2007A formal total synthesis of (+)-estrone (4% overall yield; ca. 12 steps) could be achieved via the Torgov diene. An asymmetric allylic substitution is the key step for the construction of the chiral quaternary carbon center of a synthetic intermediate which was converted in four steps to the Torgov diene. [reaction: see text]
Darunee, Soorukram, Paul, Knochel
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RADIOIMMUNOASSAY OF ESTRONE AND ESTRADIOL
Acta Endocrinologica, 1970ABSTRACT Antibodies to estradiol were produced by immunization of sheep with 17β-estradiol-succinyl-BSA. The antiserum cross reacted readily with estrone and was used for radioimmunoassay of plasma estrone and estradiol. The method includes ether extraction, separation of estrone and estradiol by Sephadex LH-20 column chromatography and radio ...
G, Mikhail +3 more
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Chiral Hydrogenation of Estrone and Estrone-3-Methyl Ether
1995We have previously studied the use of enantiomeric chiral reducing agents in solution to control the direction of the hydrogenation of the keto group of estrone and estrone-3-methyl ether [1]. The complex catalysts chiral hydrosilane-rhodium-( +)- or (-)-DIOP or (+)- or (-)-BINAP allowed different stereoselectivities in the formation of the 17α- and ...
Gy Göndös +3 more
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