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Estrone sulfonates as inhibitors of estrone sulfatase

Steroids, 1997
In our continuing quest to design efficient inhibitors of estrone sulfatase activity and to assess the recognition of estrone sulfate surrogates by estrone sulfatase, we synthesized and evaluated several sulfonate derivatives of 5,6,7,8-tetrahydronaphth-2-ol and estrone.
Barry V L Potter   +2 more
exaly   +3 more sources

Estrone sulfate analogs as estrone sulfatase inhibitors

Steroids, 1995
The high serum concentration of estrone sulfate and the presence of estrone sulfatase in breast tumors constitute an important mechanism of local synthesis of estrogens in the tissue. Thus, inhibitors of estrone sulfatase may be effective in the treatment of estrogen-dependent breast cancer.
P K Li, Leif Dibbelt, L Dibbelt
exaly   +3 more sources

A molecularly imprinted polymer-coated nanocomposite of magnetic nanoparticles for estrone recognition

open access: yesTalanta, 2009
In this study, we synthesized Fe(3)O(4) magnetic nanoparticles coated estrone-imprinted polymer with controlled size using a semi-covalent imprinting strategy. In this protocol, the estrone-silica monomer complex (EstSi) was synthesized by the reaction 3-
Langxing Chen, Xiwen He
exaly   +2 more sources

Adsorption of estrone in microfiltration membrane filters

open access: yesChemical Engineering Journal, 2010
Adsorption of estrone was identified in microfiltration membrane filters with 0.1-0.45 mu m nominal pore sizes. This phenomenon is of concern as it may lead to distortion when such filters are used to process estrone solutions prior to chromatography ...
Jie Han, Wei Gao
exaly   +2 more sources

Rejection of estrone by nanofiltration: Influence of solution chemistry

open access: yesJournal of Membrane Science, 2007
The objective of this study was to investigate the rejection of steroid hormone estrone by NF membranes as a function of feed water chemistry. Experimental results indicated that estrone rejection by NF membranes in electrolyte background solution ...
Xue Jin
exaly   +2 more sources

Comparative Fate of Estrone and Estrone Sulfate in Man

The Journal of Clinical Endocrinology & Metabolism, 1973
Estrone-14C and estrone sulfate-3H were simultaneously injected into a 37-yr-old woman and disposition of the two isotopes was followed. The products of estrone sulfate were excreted in urine more rapidly and to a greater extent than those of the coadministered estrone.
J, Fishman, L, Hellman
openaire   +2 more sources

Chemisorption of estrone in nylon microfiltration membranes: Adsorption mechanism and potential use for estrone removal from water

open access: yesWater Research, 2012
Estrone is a representative steroid estrogen contaminant that has been detected in effluents from sewage treatment facilities, as well as in surface and ground waters.
Jie Han, Wei Gao, Jiangyong Hu
exaly   +2 more sources

An expeditious synthesis of estrone

Journal of Steroid Biochemistry, 1975
Abstract The Tris annelating agent, 6-(2-methyl-6-pyridyl-hex-l-ene-3-one), has been synthesized in four steps from the readily available 2,6-lutidine. To this 12-carbon ensemble is added, in a Michael fashion, 2-methycyclopentane-1,3-dione. The prochiral pyridyltrione, so produced, can be cyclized to afford 4-(2-α-picolylethyl)-hydrind-4-ene-3,7 ...
S, Danishefsky, P, Cain
openaire   +2 more sources

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